PMID- 26345660
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150908
LR  - 20201001
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2015
DP  - 2015
TI  - Curcumin Attenuates Gentamicin-Induced Kidney Mitochondrial Alterations: Possible 
      Role of a Mitochondrial Biogenesis Mechanism.
PG  - 917435
LID - 10.1155/2015/917435 [doi]
LID - 917435
AB  - It has been shown that curcumin (CUR), a polyphenol derived from Curcuma longa, 
      exerts a protective effect against gentamicin- (GM-) induced nephrotoxicity in 
      rats, associated with a preservation of the antioxidant status. Although 
      mitochondrial dysfunction is a hallmark in the GM-induced renal injury, the role 
      of CUR in mitochondrial protection has not been studied. In this work, LLC-PK1 
      cells were preincubated 24 h with CUR and then coincubated 48 h with CUR and 
      8 mM GM. Treatment with CUR attenuated GM-induced drop in cell viability and led 
      to an increase in nuclear factor (erythroid-2)-related factor 2 (Nrf2) nuclear 
      accumulation and peroxisome proliferator-activated receptor gamma coactivator-1 
      alpha (PGC-1alpha) cell expression attenuating GM-induced losses in these proteins. 
      In vivo, Wistar rats were injected subcutaneously with GM (75 mg/Kg/12 h) during 
      7 days to develop kidney mitochondrial alterations. CUR (400 mg/Kg/day) was 
      administered orally 5 days before and during the GM exposure. The GM-induced 
      mitochondrial alterations in ultrastructure and bioenergetics as well as decrease 
      in activities of respiratory complexes I and IV and induction of 
      calcium-dependent permeability transition were mostly attenuated by CUR. 
      Protection of CUR against GM-induced nephrotoxicity could be in part mediated by 
      maintenance of mitochondrial functions and biogenesis with some participation of 
      the nuclear factor Nrf2.
FAU - Negrette-Guzman, Mario
AU  - Negrette-Guzman M
AD  - Departamento de Biologia, Facultad de Quimica, UNAM, 04510 Ciudad de Mexico, DF, 
      Mexico.
FAU - Garcia-Nino, Wylly Ramses
AU  - Garcia-Nino WR
AD  - Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiologia 
      "Ignacio Chavez", 14080 Ciudad de Mexico, DF, Mexico.
FAU - Tapia, Edilia
AU  - Tapia E
AD  - Laboratorio de Fisiopatologia Renal, Instituto Nacional de Cardiologia "Ignacio 
      Chavez", 14080 Ciudad de Mexico, DF, Mexico.
FAU - Zazueta, Cecilia
AU  - Zazueta C
AD  - Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiologia 
      "Ignacio Chavez", 14080 Ciudad de Mexico, DF, Mexico.
FAU - Huerta-Yepez, Sara
AU  - Huerta-Yepez S
AD  - Unidad de Investigacion en Enfermedades Oncologicas, Hospital Infantil de Mexico 
      "Federico Gomez", 06720 Ciudad de Mexico, DF, Mexico.
FAU - Leon-Contreras, Juan Carlos
AU  - Leon-Contreras JC
AD  - Departamento de Patologia, Instituto Nacional de Ciencias Medicas y Nutricion 
      "Salvador Zubiran", 14000 Ciudad de Mexico, DF, Mexico.
FAU - Hernandez-Pando, Rogelio
AU  - Hernandez-Pando R
AD  - Departamento de Patologia, Instituto Nacional de Ciencias Medicas y Nutricion 
      "Salvador Zubiran", 14000 Ciudad de Mexico, DF, Mexico.
FAU - Aparicio-Trejo, Omar Emiliano
AU  - Aparicio-Trejo OE
AD  - Departamento de Biologia, Facultad de Quimica, UNAM, 04510 Ciudad de Mexico, DF, 
      Mexico.
FAU - Madero, Magdalena
AU  - Madero M
AD  - Departamento de Nefrologia, Instituto Nacional de Cardiologia "Ignacio Chavez", 
      14080 Ciudad de Mexico, DF, Mexico.
FAU - Pedraza-Chaverri, Jose
AU  - Pedraza-Chaverri J
AD  - Departamento de Biologia, Facultad de Quimica, UNAM, 04510 Ciudad de Mexico, DF, 
      Mexico.
LA  - eng
PT  - Journal Article
DEP - 20150805
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC4541007
EDAT- 2015/09/09 06:00
MHDA- 2015/09/09 06:01
PMCR- 2015/08/05
CRDT- 2015/09/09 06:00
PHST- 2015/05/07 00:00 [received]
PHST- 2015/07/03 00:00 [revised]
PHST- 2015/07/15 00:00 [accepted]
PHST- 2015/09/09 06:00 [entrez]
PHST- 2015/09/09 06:00 [pubmed]
PHST- 2015/09/09 06:01 [medline]
PHST- 2015/08/05 00:00 [pmc-release]
AID - 10.1155/2015/917435 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2015;2015:917435. doi: 10.1155/2015/917435. 
      Epub 2015 Aug 5.