PMID- 26345801
OWN - NLM
STAT- MEDLINE
DCOM- 20160610
LR  - 20220318
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 3
DP  - 2015 Jul 31
TI  - Association of TLR2 and TLR4 non-missense single nucleotide polymorphisms with 
      type 2 diabetes risk in a southern Chinese population: a case-control study.
PG  - 8694-705
LID - 10.4238/2015.July.31.18 [doi]
AB  - Toll-like receptors (TLRs), the triggers of the innate and adaptive immune 
      responses, are involved in the pathogenesis of type 2 diabetes mellitus (T2DM). 
      Several studies have investigated the effects of genetic polymorphisms in TLR4 
      and TLR2, but they have yielded limited results. We investigated whether 
      non-missense genetic polymorphisms in the regulatory regions of TLR4 and TLR2 
      were related to T2DM in a southern Chinese population. Single nucleotide 
      polymorphisms (SNPs) in TLR4 (rs1927911, rs11536889, rs1927907, rs1927906, 
      rs1927914, rs7873784, and rs2149356) and TLR2 (rs1898830, rs3804099, rs4696480, 
      and rs3804100) were genotyped in 552 T2DM and 552 unrelated age- and 
      gender-matched controls by SNaPShot Multiplex assay. Genotypes GG (OR = 0.09, 
      95%CI = 0.01- 0.83, P = 0.03) and CG (OR = 0.08, 95%CI = 0.01-0.74, P = 0.03) of 
      the 3'-untranslated region (UTR) SNP rs7873784 in TLR4, and genotype AG (OR = 
      0.67, 95%CI = 0.46-0.97, P = 0.04) and allele G (OR = 0.88, 95%CI = 0.79-0.97, P 
      = 0.01) of the intron SNP rs1898830 in TLR2 were identified as protective against 
      the development of T2DM in southern Chinese people. In contrast, a meta-analysis 
      of rs1927911 and rs1927914 showed no association. Haplotypes AGTT (OR = 0.34, 
      95%CI = 0.15-0.77, P = 0.01) and AATT (OR = 1.20, 95%CI = 1.01- 1.44, P = 0.05) 
      in TLR2 were significantly associated with susceptibility to T2DM. Our results 
      suggest that the effects of non-missense polymorphisms located in the regulatory 
      regions of TLR4 and TLR2 should not be neglected in T2DM association analysis.
FAU - Huang, W H
AU  - Huang WH
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
FAU - Nie, L H
AU  - Nie LH
AD  - Department of Endocrinology, The First Affiliated Hospital of Jinan University, 
      Guangzhou, Guangdong, China.
FAU - Zhang, L J
AU  - Zhang LJ
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
FAU - Jing, L P
AU  - Jing LP
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
FAU - Dong, F
AU  - Dong F
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
FAU - Wang, M
AU  - Wang M
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
FAU - Zhang, N
AU  - Zhang N
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
FAU - Liu, Y
AU  - Liu Y
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
FAU - Zhang, B H
AU  - Zhang BH
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
FAU - Chen, C
AU  - Chen C
AD  - Department of Parasitology, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
FAU - Lin, H S
AU  - Lin HS
AD  - Department of Statistics, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
FAU - Wei, X C
AU  - Wei XC
AD  - Family Planning Research Institute of Guangdong, Guangzhou, Guangdong, China.
FAU - Yang, G
AU  - Yang G
AD  - Department of Parasitology, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
FAU - Jing, C X
AU  - Jing CX
AD  - Department of Epidemiology, School of Medicine, Jinan University, Guangzhou, 
      Guangdong, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20150731
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (TLR2 protein, human)
RN  - 0 (TLR4 protein, human)
RN  - 0 (Toll-Like Receptor 2)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - China
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Gene Frequency
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Toll-Like Receptor 2/*genetics
MH  - Toll-Like Receptor 4/*genetics
EDAT- 2015/09/09 06:00
MHDA- 2016/06/11 06:00
CRDT- 2015/09/09 06:00
PHST- 2015/09/09 06:00 [entrez]
PHST- 2015/09/09 06:00 [pubmed]
PHST- 2016/06/11 06:00 [medline]
AID - gmr5612 [pii]
AID - 10.4238/2015.July.31.18 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Jul 31;14(3):8694-705. doi: 10.4238/2015.July.31.18.