PMID- 26345870
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20150908
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 3
DP  - 2015 Aug 10
TI  - Estrogen receptor 1 PvuII and XbaI polymorphisms and susceptibility to 
      Alzheimer's disease: a meta-analysis.
PG  - 9361-9
LID - 10.4238/2015.August.10.17 [doi]
AB  - The aim of this study was to explore whether estrogen receptor 1 (ESR1) PvuII and 
      XbaI polymorphisms are associated with susceptibility to Alzheimer's disease 
      (AD). We conducted a meta-analysis of the associations between AD and ESR1 PvuII 
      and XbaI polymorphisms as well as haplotypes of the ESR1 PvuII and XbaI 
      polymorphisms. A total of 1359 patients and 1387 controls from 9 studies on the 
      ESR1 PvuII polymorphism and 1525 patients and 1575 controls from 8 studies on the 
      ESR1 XbaI polymorphism were included in this meta-analysis. Gender-specific 
      meta-analysis showed an association between the ESR1 PP+Pp genotype and AD in 
      males (OR = 0.302, 95%CI = 0.100-0.914, P = 0.034), but not in females. No 
      association was observed between AD and the ESR1 XbaI X allele (OR = 1.114, 95%CI 
      = 0.868-1.429, P = 0.397). However, country-specific meta-analysis identified an 
      association between AD and the ESR1 X allele in Japanese (OR = 1.386, 95%CI = 
      1.055-1.822, P = 0.019), but not Chinese or Italian populations. Meta-analyses 
      results indicated an association between the PP/XX haplotypes and AD in Chinese 
      population (OR for PP/XX vs others = 2.758, 95%CI = 1.750-4.346, P = 1.2 x 
      10(-6)). This meta-analysis showed associations between the ESR1 PvuII 
      polymorphism and AD susceptibility in males, between AD risk and the ESR1 XbaI 
      polymorphism in the Japanese population, and between the PP/XX haplotype and AD 
      susceptibility in the Chinese population.
FAU - Lee, Y H
AU  - Lee YH
AD  - Division of Rheumatology, Department of Internal Medicine, Korea University 
      College of Medicine, Seoul, Korea.
FAU - Song, G G
AU  - Song GG
AD  - Division of Rheumatology, Department of Internal Medicine, Korea University 
      College of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20150810
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Alleles
MH  - Alzheimer Disease/*genetics
MH  - Case-Control Studies
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - *Genetic Predisposition to Disease
MH  - Haplotypes
MH  - Humans
MH  - Male
MH  - Odds Ratio
MH  - *Polymorphism, Restriction Fragment Length
MH  - Publication Bias
EDAT- 2015/09/09 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/09/09 06:00
PHST- 2015/09/09 06:00 [entrez]
PHST- 2015/09/09 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - gmr6114 [pii]
AID - 10.4238/2015.August.10.17 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Aug 10;14(3):9361-9. doi: 10.4238/2015.August.10.17.