PMID- 26345873
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20150908
IS  - 1676-5680 (Electronic)
IS  - 1676-5680 (Linking)
VI  - 14
IP  - 3
DP  - 2015 Aug 14
TI  - Frequency of SNP -336A/G in the promoter region of CD209 in a population from 
      northeastern Brazil.
PG  - 9395-403
LID - 10.4238/2015.August.14.3 [doi]
AB  - Dendritic cells (DCs) mediate the initiation of the immune response against a 
      variety of pathogens. The DC-SIGN receptor is encoded by the gene CD209 and is 
      expressed on the surface of DCs. It binds to mannose-rich carbohydrates and 
      enables the recognition of bacteria, fungi, parasites, and viruses. SNP -336A/G 
      in the promoter region of CD209 influences the expression of the DC-SIGN 
      receptor. Several studies have associated this SNP with an increased 
      susceptibility to infectious diseases and the development of more severe forms of 
      disease. Therefore, the aim of this study was to determine the prevalence of SNP 
      -336A/G in a population from northeastern Brazil. We analyzed 181 individuals 
      from the general population of Parnaiba, Piaui, Brazil, of which 37% were men and 
      63% were women. SNP -336A/G was detected by polymerase chain reaction and 
      treatment with the restriction enzyme MscI and visualized by electrophoresis on 
      an 8% polyacrylamide gel stained with silver nitrate. Of the individuals 
      analyzed, 116 (64.1%) were homozygous AA, 57 (31.5%) were heterozygous (AG), and 
      8 (4.4%) were homozygous GG. The allele frequency of -336G was 20.2%. Genotype 
      frequencies were in Hardy-Weinberg equilibrium. To the best of our knowledge, 
      this is the first report to describe the frequency of the CD209 SNP -336A/G in a 
      population in the State of Piaui. Further studies are needed to determine the 
      relationship between this SNP and the vulnerability of this population to major 
      infectious diseases.
FAU - Costa, P N
AU  - Costa PN
AD  - Laboratorio de Bioquimica e Biologia de Micro-Organismos e Plantas, Universidade 
      Federal do Piaui, Campus Ministro Reis Velloso, Parnaiba, PI, Brasil.
FAU - Ferreira-Fernandes, H
AU  - Ferreira-Fernandes H
AD  - Laboratorio de Genetica e Biologia Molecular, Departamento de Biomedicina, 
      Universidade Federal do Piaui.
FAU - de Oliveira, J S
AU  - de Oliveira JS
AD  - Laboratorio de Bioquimica e Biologia de Micro-Organismos e Plantas, Universidade 
      Federal do Piaui, Campus Ministro Reis Velloso, Parnaiba, PI, Brasil.
FAU - Pereira, A C T C
AU  - Pereira AC
AD  - Laboratorio de Bioquimica e Biologia de Micro-Organismos e Plantas, Universidade 
      Federal do Piaui, Campus Ministro Reis Velloso, Parnaiba, PI, Brasil.
FAU - Pinto, G R
AU  - Pinto GR
AD  - Laboratorio de Genetica e Biologia Molecular, Departamento de Biomedicina, 
      Universidade Federal do Piaui.
FAU - Ferreira, G P
AU  - Ferreira GP
AD  - Laboratorio de Bioquimica e Biologia de Micro-Organismos e Plantas, Universidade 
      Federal do Piaui, Campus Ministro Reis Velloso, Parnaiba, PI, Brasil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150814
PL  - Brazil
TA  - Genet Mol Res
JT  - Genetics and molecular research : GMR
JID - 101169387
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (DC-specific ICAM-3 grabbing nonintegrin)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Receptors, Cell Surface)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - *Alleles
MH  - Brazil
MH  - Cell Adhesion Molecules/*genetics
MH  - Female
MH  - *Gene Frequency
MH  - *Genetics, Population
MH  - Genotype
MH  - Humans
MH  - Lectins, C-Type/*genetics
MH  - Male
MH  - Middle Aged
MH  - *Polymorphism, Single Nucleotide
MH  - *Promoter Regions, Genetic
MH  - Receptors, Cell Surface/*genetics
EDAT- 2015/09/09 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/09/09 06:00
PHST- 2015/09/09 06:00 [entrez]
PHST- 2015/09/09 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - gmr5097 [pii]
AID - 10.4238/2015.August.14.3 [doi]
PST - epublish
SO  - Genet Mol Res. 2015 Aug 14;14(3):9395-403. doi: 10.4238/2015.August.14.3.