PMID- 26346319
OWN - NLM
STAT- MEDLINE
DCOM- 20160803
LR  - 20181113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 5
DP  - 2015 Sep 8
TI  - Modeling the interplay between the HIF-1 and p53 pathways in hypoxia.
PG  - 13834
LID - 10.1038/srep13834 [doi]
LID - 13834
AB  - Both the hypoxia-inducible factor-1 (HIF-1) and tumor suppressor p53 are involved 
      in the cellular response to hypoxia. How the two transcription factors interact 
      to determine cell fates is less well understood. Here, we developed a network 
      model to characterize crosstalk between the HIF-1 and p53 pathways, taking into 
      account that HIF-1alpha and p53 are targeted for proteasomal degradation by Mdm2 and 
      compete for binding to limiting co-activator p300. We reported the network 
      dynamics under various hypoxic conditions and revealed how the stabilization and 
      transcriptional activities of p53 and HIF-1alpha are modulated to determine the cell 
      fate. We showed that both the transrepression and transactivation activities of 
      p53 promote apoptosis induction. This work provides new insight into the 
      mechanism for the cellular response to hypoxia.
FAU - Zhou, Chun-Hong
AU  - Zhou CH
AD  - National Laboratory of Solid State Microstructures and Department of Physics, 
      Nanjing University, Nanjing 210093, China.
AD  - School of Physics and Electronic Engineering, Jiangsu Normal University, Xuzhou 
      221116, China.
FAU - Zhang, Xiao-Peng
AU  - Zhang XP
AD  - Kuang Yaming Honors School, Nanjing University, Nanjing 210093, China.
FAU - Liu, Feng
AU  - Liu F
AD  - National Laboratory of Solid State Microstructures and Department of Physics, 
      Nanjing University, Nanjing 210093, China.
AD  - Collaborative Innovation Center of Advanced Microstructures, Nanjing University, 
      Nanjing 210093, China.
FAU - Wang, Wei
AU  - Wang W
AD  - National Laboratory of Solid State Microstructures and Department of Physics, 
      Nanjing University, Nanjing 210093, China.
AD  - Collaborative Innovation Center of Advanced Microstructures, Nanjing University, 
      Nanjing 210093, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150908
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (MicroRNAs)
RN  - 0 (Tumor Suppressor Protein p53)
RN  - EC 2.7.11.1 (ATR protein, human)
RN  - EC 2.7.11.1 (Ataxia Telangiectasia Mutated Proteins)
RN  - EC 3.6.5.2 (Proto-Oncogene Proteins p21(ras))
SB  - IM
MH  - Apoptosis/genetics
MH  - Ataxia Telangiectasia Mutated Proteins/metabolism
MH  - Humans
MH  - Hypoxia/genetics/*metabolism
MH  - Hypoxia-Inducible Factor 1, alpha Subunit/genetics/*metabolism
MH  - MicroRNAs/genetics
MH  - *Models, Biological
MH  - Protein Binding
MH  - Proto-Oncogene Proteins p21(ras)/genetics/metabolism
MH  - *Signal Transduction
MH  - Tumor Suppressor Protein p53/genetics/*metabolism
PMC - PMC4561886
EDAT- 2015/09/09 06:00
MHDA- 2016/08/04 06:00
PMCR- 2015/09/08
CRDT- 2015/09/09 06:00
PHST- 2015/04/29 00:00 [received]
PHST- 2015/08/10 00:00 [accepted]
PHST- 2015/09/09 06:00 [entrez]
PHST- 2015/09/09 06:00 [pubmed]
PHST- 2016/08/04 06:00 [medline]
PHST- 2015/09/08 00:00 [pmc-release]
AID - srep13834 [pii]
AID - 10.1038/srep13834 [doi]
PST - epublish
SO  - Sci Rep. 2015 Sep 8;5:13834. doi: 10.1038/srep13834.