PMID- 26346467
OWN - NLM
STAT- MEDLINE
DCOM- 20161216
LR  - 20201019
IS  - 1447-0756 (Electronic)
IS  - 1341-8076 (Linking)
VI  - 41
IP  - 10
DP  - 2015 Oct
TI  - Interleukin-18 gene polymorphisms and risk of recurrent pregnancy loss: A 
      systematic review and meta-analysis.
PG  - 1506-13
LID - 10.1111/jog.12800 [doi]
AB  - Interleukin-18 (IL-18) plays a potential pathological role in recurrent pregnancy 
      loss (RPL). The results of published studies on the relationship between IL-18 
      gene promoter polymorphisms (-137G/C and-607C/A) and RPL risk remain 
      controversial. This meta-analysis was performed to evaluate the association of 
      IL-18, -137G/C and-607C/A gene polymorphisms with the risk of RPL under 
      recessive, dominant and additive genetic models. A literature search was 
      conducted in Medline, Embase and Web of Science for studies that described the 
      effect of IL-18 gene polymorphisms on RPL risk. The numbers of each -137G/C 
      and-607C/A genotype in the case and control groups were extracted. Quality of the 
      original studies' methodology was also assessed. Meta-analysis was performed 
      using Stata 13.1 software and the fixed effect model was used. Five articles were 
      included in this meta-analysis. No significant heterogeneity between the studies 
      was noted. The IL-18 -137 G/C polymorphism was significantly associated with an 
      increased risk of RPL under a recessive genetic model (CC vs. GG + CG: odds 
      ratio = 1.56, 95% confidence interval = 1.13 ~ 2.15). For the -607C/A mutation, 
      we failed to find any association under any genetic models. The Egger's 
      regression asymmetry test showed no publication bias. Our present study indicates 
      a positive association between the CC genotype of the IL-18 -137G/C gene and RPL 
      risk. Future well-designed large studies are needed to validate the association 
      between IL-18 gene polymorphisms and the risk of RPL.
CI  - (c) 2015 Japan Society of Obstetrics and Gynecology.
FAU - Chen, Hui
AU  - Chen H
AD  - Clinical Epidemiology Unit, Qilu Hospital, Shandong University, Jinan, China.
AD  - Department of Epidemiology, School of Public Health, Shandong University, Jinan, 
      China.
FAU - Yang, Xiaorong
AU  - Yang X
AD  - Department of Epidemiology, School of Public Health, Shandong University, Jinan, 
      China.
FAU - Du, Jinge
AU  - Du J
AD  - Clinical Epidemiology Unit, Qilu Hospital, Shandong University, Jinan, China.
AD  - Department of Epidemiology, School of Public Health, Shandong University, Jinan, 
      China.
FAU - Lu, Ming
AU  - Lu M
AD  - Clinical Epidemiology Unit, Qilu Hospital, Shandong University, Jinan, China.
AD  - Department of Epidemiology, School of Public Health, Shandong University, Jinan, 
      China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20150908
PL  - Australia
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 0 (IL18 protein, human)
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Abortion, Habitual/*genetics
MH  - Female
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Polymorphism, Genetic
MH  - Pregnancy
OTO - NOTNLM
OT  - interleukin-18
OT  - meta-analysis
OT  - polymorphism
OT  - recurrent pregnancy loss
EDAT- 2015/09/09 06:00
MHDA- 2016/12/17 06:00
CRDT- 2015/09/09 06:00
PHST- 2015/04/15 00:00 [received]
PHST- 2015/06/09 00:00 [accepted]
PHST- 2015/09/09 06:00 [entrez]
PHST- 2015/09/09 06:00 [pubmed]
PHST- 2016/12/17 06:00 [medline]
AID - 10.1111/jog.12800 [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2015 Oct;41(10):1506-13. doi: 10.1111/jog.12800. Epub 2015 
      Sep 8.