PMID- 26346482
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150908
LR  - 20201001
IS  - 1671-5411 (Print)
IS  - 1671-5411 (Linking)
VI  - 12
IP  - 4
DP  - 2015 Jul
TI  - Mitral peak early diastolic filling velocity to deceleration time ratio as a 
      predictor of prognosis in patients with chronic heart failure and preserved or 
      reduced ejection fraction.
PG  - 346-52
LID - 10.11909/j.issn.1671-5411.2015.04.006 [doi]
AB  - OBJECTIVE: Doppler derived mitral peak early diastolic filling velocity to 
      deceleration time ratio (E/DT) has been proposed as parameter for predicting 
      prognosis in general population. This study prospectively investigates the 
      incremental prognostic value of E/DT over clinical, conventional 
      echocardiographic and mitral-Doppler variables in patients hospitalized for 
      decompensated heart failure (HF). METHODS: We analyzed 95 HF patients (mean age 
      64.8 +/- 12.2 years) hospitalized at our institution from January 2010 to March 
      2012. The primary end-point was cardiac death or hospitalization, whichever 
      occurred first. Cox regression analysis was performed to identify significant 
      predictors of outcomes. RESULTS: During follow-up (median 37.7 months) 13 
      patients died and 44 were hospitalized for a cardiac event. At univariable 
      analysis, New York Heart Association (NYHA) functional class, furosemide dosage, 
      lateral tricuspidal annular plane systolic excursion, deceleration time and E/DT 
      were predictive of outcome. At multivariable analysis, E/DT was the only 
      predictor of prognosis (hazard ratio = 1.02, P = 0.018), giving incremental 
      prognostic information to clinical and other echocardio-graphic measures (global 
      chi-square from 15.4 to 25.2; P = 0.032). CONCLUSIONS: E/DT gives independent and 
      incremental prognostic information in HF patients.
FAU - Pirozzi, Flora
AU  - Pirozzi F
AD  - Department of Translational Medical Sciences, Section of Internal Medicine, 
      Federico II University, Naples, Italy.
FAU - Paglia, Antonella
AU  - Paglia A
AD  - Department of Translational Medical Sciences, Section of Internal Medicine, 
      Federico II University, Naples, Italy.
FAU - Sasso, Laura
AU  - Sasso L
AD  - Department of Translational Medical Sciences, Section of Internal Medicine, 
      Federico II University, Naples, Italy.
FAU - Abete, Pasquale
AU  - Abete P
AD  - Department of Translational Medical Sciences, Section of Internal Medicine, 
      Federico II University, Naples, Italy.
FAU - Carlomagno, Angelo
AU  - Carlomagno A
AD  - Department of Translational Medical Sciences, Section of Internal Medicine, 
      Federico II University, Naples, Italy.
FAU - Tocchetti, Carlo G
AU  - Tocchetti CG
AD  - Department of Translational Medical Sciences, Section of Internal Medicine, 
      Federico II University, Naples, Italy.
FAU - Bonaduce, Domenico
AU  - Bonaduce D
AD  - Department of Translational Medical Sciences, Section of Internal Medicine, 
      Federico II University, Naples, Italy.
FAU - Petretta, Mario
AU  - Petretta M
AD  - Department of Translational Medical Sciences, Section of Internal Medicine, 
      Federico II University, Naples, Italy.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Geriatr Cardiol
JT  - Journal of geriatric cardiology : JGC
JID - 101237881
PMC - PMC4554776
OTO - NOTNLM
OT  - Echocardiographic evaluation
OT  - Left ventricular function
OT  - Risk stratification
EDAT- 2015/09/09 06:00
MHDA- 2015/09/09 06:01
PMCR- 2015/07/01
CRDT- 2015/09/09 06:00
PHST- 2015/02/19 00:00 [received]
PHST- 2015/04/09 00:00 [revised]
PHST- 2015/06/01 00:00 [accepted]
PHST- 2015/09/09 06:00 [entrez]
PHST- 2015/09/09 06:00 [pubmed]
PHST- 2015/09/09 06:01 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - jgc-12-04-346 [pii]
AID - 10.11909/j.issn.1671-5411.2015.04.006 [doi]
PST - ppublish
SO  - J Geriatr Cardiol. 2015 Jul;12(4):346-52. doi: 
      10.11909/j.issn.1671-5411.2015.04.006.