PMID- 26347138
OWN - NLM
STAT- MEDLINE
DCOM- 20151224
LR  - 20181113
IS  - 1540-8140 (Electronic)
IS  - 0021-9525 (Print)
IS  - 0021-9525 (Linking)
VI  - 210
IP  - 6
DP  - 2015 Sep 14
TI  - BDNF modulates heart contraction force and long-term homeostasis through 
      truncated TrkB.T1 receptor activation.
PG  - 1003-12
AB  - Brain-derived neurotrophic factor (BDNF) is critical for mammalian development 
      and plasticity of neuronal circuitries affecting memory, mood, anxiety, pain 
      sensitivity, and energy homeostasis. Here we report a novel unexpected role of 
      BDNF in regulating the cardiac contraction force independent of the nervous 
      system innervation. This function is mediated by the truncated TrkB.T1 receptor 
      expressed in cardiomyocytes. Loss of TrkB.T1 in these cells impairs calcium 
      signaling and causes cardiomyopathy. TrkB.T1 is activated by BDNF produced by 
      cardiomyocytes, suggesting an autocrine/paracrine loop. These findings unveil a 
      novel signaling mechanism in the heart that is activated by BDNF and provide 
      evidence for a global role of this neurotrophin in the homeostasis of the 
      organism by signaling through different TrkB receptor isoforms.
FAU - Fulgenzi, Gianluca
AU  - Fulgenzi G
FAU - Tomassoni-Ardori, Francesco
AU  - Tomassoni-Ardori F
FAU - Babini, Lucia
AU  - Babini L
FAU - Becker, Jodi
AU  - Becker J
FAU - Barrick, Colleen
AU  - Barrick C
FAU - Puverel, Sandrine
AU  - Puverel S
FAU - Tessarollo, Lino
AU  - Tessarollo L
LA  - eng
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PL  - United States
TA  - J Cell Biol
JT  - The Journal of cell biology
JID - 0375356
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - EC 2.7.10.1 (Ntrk2 protein, mouse)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Autocrine Communication
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism/pharmacology
MH  - Calcium Signaling
MH  - Cardiomyopathies/*enzymology/genetics/pathology/physiopathology
MH  - Enzyme Activation
MH  - Genotype
MH  - Isolated Heart Preparation
MH  - Male
MH  - Membrane Glycoproteins/deficiency/genetics/*metabolism
MH  - Mice, Knockout
MH  - Mice, Transgenic
MH  - *Muscle Strength/drug effects
MH  - *Myocardial Contraction/drug effects
MH  - Myocytes, Cardiac/drug effects/*enzymology/pathology
MH  - Paracrine Communication
MH  - Phenotype
MH  - Protein-Tyrosine Kinases/deficiency/genetics/*metabolism
MH  - Signal Transduction
MH  - Time Factors
PMC - PMC4576863
EDAT- 2015/09/09 06:00
MHDA- 2015/12/25 06:00
PMCR- 2016/03/14
CRDT- 2015/09/09 06:00
PHST- 2015/09/09 06:00 [entrez]
PHST- 2015/09/09 06:00 [pubmed]
PHST- 2015/12/25 06:00 [medline]
PHST- 2016/03/14 00:00 [pmc-release]
AID - jcb.201502100 [pii]
AID - 201502100 [pii]
AID - 10.1083/jcb.201502100 [doi]
PST - ppublish
SO  - J Cell Biol. 2015 Sep 14;210(6):1003-12. doi: 10.1083/jcb.201502100.