PMID- 26347681
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150908
LR  - 20201001
IS  - 1664-1078 (Print)
IS  - 1664-1078 (Electronic)
IS  - 1664-1078 (Linking)
VI  - 6
DP  - 2015
TI  - The brain-derived neurotrophic factor (BDNF) val66met polymorphism differentially 
      affects performance on subscales of the Wechsler Memory Scale - Third Edition 
      (WMS-III).
PG  - 1212
LID - 10.3389/fpsyg.2015.01212 [doi]
LID - 1212
AB  - Single nucleotide polymorphisms in the brain-derived neurotrophic factor (BDNF) 
      gene and the catechol-O-methyltransferase (COMT) gene influence brain structure 
      and function, as well as cognitive abilities. They are most influential in the 
      hippocampus and prefrontal cortex (PFC), respectively. Recall and recognition are 
      forms of memory proposed to have different neural substrates, with recall having 
      a greater dependence on the PFC and hippocampus. This study aimed to determine 
      whether the BDNF val(66)met or COMT val(158)met polymorphisms differentially 
      affect recall and recognition, and whether these polymorphisms interact. A sample 
      of 100 healthy adults was assessed on recall and familiarity-based recognition 
      using the Faces and Family Pictures subscales of the Wechsler Memory Scale - 
      Third Edition (WMS-III). COMT genotype did not affect performance on either task. 
      The BDNF polymorphism (i.e., met carriers relative to val homozygotes) was 
      associated with poorer recall ability, while not influencing recognition. 
      Combining subscale scores in memory tests such as the WMS might obscure gene 
      effects. Our results demonstrate the importance of distinguishing between recall 
      and familiarity-based recognition in neurogenetics research.
FAU - Lamb, Yvette N
AU  - Lamb YN
AD  - School of Psychology, Faculty of Science, The University of Auckland, Auckland 
      New Zealand.
FAU - Thompson, Christopher S
AU  - Thompson CS
AD  - School of Psychology, Faculty of Science, The University of Auckland, Auckland 
      New Zealand.
FAU - McKay, Nicole S
AU  - McKay NS
AD  - School of Psychology, Faculty of Science, The University of Auckland, Auckland 
      New Zealand.
FAU - Waldie, Karen E
AU  - Waldie KE
AD  - School of Psychology, Faculty of Science, The University of Auckland, Auckland 
      New Zealand.
FAU - Kirk, Ian J
AU  - Kirk IJ
AD  - School of Psychology, Faculty of Science, The University of Auckland, Auckland 
      New Zealand.
LA  - eng
PT  - Journal Article
DEP - 20150817
PL  - Switzerland
TA  - Front Psychol
JT  - Frontiers in psychology
JID - 101550902
PMC - PMC4538220
OTO - NOTNLM
OT  - BDNF
OT  - memory
OT  - neurogenetics
OT  - recall
OT  - recognition
EDAT- 2015/09/09 06:00
MHDA- 2015/09/09 06:01
PMCR- 2015/08/17
CRDT- 2015/09/09 06:00
PHST- 2015/02/05 00:00 [received]
PHST- 2015/07/30 00:00 [accepted]
PHST- 2015/09/09 06:00 [entrez]
PHST- 2015/09/09 06:00 [pubmed]
PHST- 2015/09/09 06:01 [medline]
PHST- 2015/08/17 00:00 [pmc-release]
AID - 10.3389/fpsyg.2015.01212 [doi]
PST - epublish
SO  - Front Psychol. 2015 Aug 17;6:1212. doi: 10.3389/fpsyg.2015.01212. eCollection 
      2015.