PMID- 26348672
OWN - NLM
STAT- MEDLINE
DCOM- 20161006
LR  - 20181113
IS  - 1872-9738 (Electronic)
IS  - 0892-0362 (Print)
IS  - 0892-0362 (Linking)
VI  - 52
IP  - Pt B
DP  - 2015 Nov-Dec
TI  - Acute and developmental behavioral effects of flame retardants and related 
      chemicals in zebrafish.
PG  - 194-209
LID - S0892-0362(15)30028-3 [pii]
LID - 10.1016/j.ntt.2015.08.010 [doi]
AB  - As polybrominated diphenyl ethers are phased out, numerous compounds are emerging 
      as potential replacement flame retardants for use in consumer and electronic 
      products. Little is known, however, about the neurobehavioral toxicity of these 
      replacements. This study evaluated the neurobehavioral effects of acute or 
      developmental exposure to t-butylphenyl diphenyl phosphate (BPDP), 2-ethylhexyl 
      diphenyl phosphate (EHDP), isodecyl diphenyl phosphate (IDDP), isopropylated 
      phenyl phosphate (IPP), tricresyl phosphate (TMPP; also abbreviated TCP), 
      triphenyl phosphate (TPHP; also abbreviated TPP), tetrabromobisphenol A (TBBPA), 
      tris (2-chloroethyl) phosphate (TCEP), tris (1,3-dichloroisopropyl) phosphate 
      (TDCIPP; also abbreviated TDCPP), tri-o-cresyl phosphate (TOCP), and 
      2,2-,4,4'-tetrabromodiphenyl ether (BDE-47) in zebrafish (Danio rerio) larvae. 
      Larvae (n approximately 24 per dose per compound) were exposed to test compounds (0.4-120 muM) 
      at sub-teratogenic concentrations either developmentally or acutely, and 
      locomotor activity was assessed at 6 days post fertilization. When given 
      developmentally, all chemicals except BPDP, IDDP and TBBPA produced behavioral 
      effects. When given acutely, all chemicals produced behavioral effects, with 
      TPHP, TBBPA, EHDP, IPP, and BPDP eliciting the most effects at the most 
      concentrations. The results indicate that these replacement flame retardants may 
      have developmental or pharmacological effects on the vertebrate nervous system.
CI  - Published by Elsevier Inc.
FAU - Jarema, Kimberly A
AU  - Jarema KA
AD  - Toxicology Assessment Division NHEERL, U.S. Environmental Protection Agency, 
      Research Triangle Park, NC, USA.
FAU - Hunter, Deborah L
AU  - Hunter DL
AD  - Integrated Systems Toxicology Division, NHEERL, U.S. Environmental Protection 
      Agency, Research Triangle Park, NC, USA.
FAU - Shaffer, Rachel M
AU  - Shaffer RM
AD  - Integrated Systems Toxicology Division, NHEERL, U.S. Environmental Protection 
      Agency, Research Triangle Park, NC, USA; Curriculum in Toxicology, University of 
      North Carolina, School of Medicine, Chapel Hill, NC, USA.
FAU - Behl, Mamta
AU  - Behl M
AD  - National Toxicology Program, National Institute of Environmental Health Sciences, 
      Research Triangle Park, NC, USA.
FAU - Padilla, Stephanie
AU  - Padilla S
AD  - Integrated Systems Toxicology Division, NHEERL, U.S. Environmental Protection 
      Agency, Research Triangle Park, NC, USA. Electronic address: 
      Padilla.stephanie@epa.gov.
LA  - eng
GR  - T32 ES007126/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20150905
PL  - United States
TA  - Neurotoxicol Teratol
JT  - Neurotoxicology and teratology
JID - 8709538
RN  - 0 (Flame Retardants)
SB  - IM
MH  - Animals
MH  - Embryonic Development/*drug effects
MH  - Flame Retardants/*toxicity
MH  - Motor Activity/*drug effects
MH  - Zebrafish
PMC - PMC4768762
MID - NIHMS760605
OTO - NOTNLM
OT  - Acute
OT  - Developmental
OT  - Flame retardants
OT  - Neurotoxicity
OT  - Zebrafish
EDAT- 2015/09/09 06:00
MHDA- 2016/10/08 06:00
PMCR- 2016/02/26
CRDT- 2015/09/09 06:00
PHST- 2015/06/12 00:00 [received]
PHST- 2015/08/06 00:00 [revised]
PHST- 2015/08/31 00:00 [accepted]
PHST- 2015/09/09 06:00 [entrez]
PHST- 2015/09/09 06:00 [pubmed]
PHST- 2016/10/08 06:00 [medline]
PHST- 2016/02/26 00:00 [pmc-release]
AID - S0892-0362(15)30028-3 [pii]
AID - 10.1016/j.ntt.2015.08.010 [doi]
PST - ppublish
SO  - Neurotoxicol Teratol. 2015 Nov-Dec;52(Pt B):194-209. doi: 
      10.1016/j.ntt.2015.08.010. Epub 2015 Sep 5.