PMID- 26350221
OWN - NLM
STAT- MEDLINE
DCOM- 20160907
LR  - 20181113
IS  - 1937-5395 (Electronic)
IS  - 1937-5387 (Linking)
VI  - 8
IP  - 8
DP  - 2015 Nov
TI  - T-Wave Alternans Is Linked to Microvascular Obstruction and to Recurrent Coronary 
      Ischemia After Myocardial Infarction.
PG  - 484-92
LID - 10.1007/s12265-015-9649-x [doi]
AB  - The purpose of this study is to investigate the relationship between T-wave 
      alternans (TWA), infarct size and microvascular obstruction (MVO) and recurrent 
      cardiac morbidity after ST elevation myocardial infarction (STEMI). One hundred 
      six patients underwent TWA testing 1-12 months and 57 patients underwent cardiac 
      magnetic resonance imaging (MRI) in the first 2-4 days after STEMI. During 
      follow-up (3.5 +/- 0.5 years), death (n = 2), ventricular tachycardia (n = 3), 
      supraventricular tachycardia (n = 4), heart failure (n = 3) and recurrent 
      coronary ischemia (n = 25) were observed. After multivariate analysis, positive 
      TWA (HR2.59, CI1.10-6.11, p0.024) and larger MVO (HR1.08, CI1.01-1.16, p0.034) 
      were associated with recurrent angina or ACS. Presence of MVO was correlated with 
      TWA (Spearman rho 0.404, p0.002) and the impairment of LVEF (-0.524, p < 0.001). 
      Patients after STEMI remain at a high risk of symptoms of coronary ischemia. The 
      presence of MVO and TWA 1-12 months after STEMI is related to each other and to 
      recurrent angina or ACS.
FAU - Flore, V
AU  - Flore V
AD  - Division of Experimental Cardiology, Department of Cardiovascular Diseases, 
      University of Leuven, Leuven, Belgium. vincent.flore@outlook.com.
AD  - Division of Clinical Cardiology, University Hospitals Leuven, Herestraat 49, 
      3000, Leuven, Belgium. vincent.flore@outlook.com.
FAU - Claus, P
AU  - Claus P
AD  - Division of Imaging and Cardiovascular Dynamics, Department of Cardiovascular 
      Diseases, University of Leuven, Leuven, Belgium.
FAU - Vos, M A
AU  - Vos MA
AD  - Department of Medical Physiology, Division of Heart and Lungs, University Medical 
      Center Utrecht, University of Utrecht, Utrecht, The Netherlands.
FAU - Vandenberk, B
AU  - Vandenberk B
AD  - Division of Experimental Cardiology, Department of Cardiovascular Diseases, 
      University of Leuven, Leuven, Belgium.
FAU - Van Soest, S
AU  - Van Soest S
AD  - Division of Experimental Cardiology, Department of Cardiovascular Diseases, 
      University of Leuven, Leuven, Belgium.
FAU - Sipido, K R
AU  - Sipido KR
AD  - Division of Experimental Cardiology, Department of Cardiovascular Diseases, 
      University of Leuven, Leuven, Belgium.
FAU - Adriaenssens, T
AU  - Adriaenssens T
AD  - Division of Clinical Cardiology, University Hospitals Leuven, Herestraat 49, 
      3000, Leuven, Belgium.
FAU - Bogaert, J
AU  - Bogaert J
AD  - Department of Imaging and Pathology, University of Leuven, Leuven, Belgium.
FAU - Desmet, W
AU  - Desmet W
AD  - Division of Clinical Cardiology, University Hospitals Leuven, Herestraat 49, 
      3000, Leuven, Belgium.
FAU - Willems, R
AU  - Willems R
AD  - Division of Experimental Cardiology, Department of Cardiovascular Diseases, 
      University of Leuven, Leuven, Belgium.
AD  - Division of Clinical Cardiology, University Hospitals Leuven, Herestraat 49, 
      3000, Leuven, Belgium.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150908
PL  - United States
TA  - J Cardiovasc Transl Res
JT  - Journal of cardiovascular translational research
JID - 101468585
SB  - IM
MH  - Acute Coronary Syndrome/diagnosis/*etiology/mortality/physiopathology
MH  - Adult
MH  - Aged
MH  - Angina Pectoris/diagnosis/*etiology/mortality/physiopathology
MH  - Arrhythmias, Cardiac/diagnosis/*etiology/mortality/physiopathology
MH  - Chi-Square Distribution
MH  - *Coronary Circulation
MH  - Electrocardiography
MH  - Female
MH  - Heart Conduction System/*physiopathology
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - *Microcirculation
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Myocardial Infarction/*complications/diagnosis/mortality/physiopathology/therapy
MH  - Predictive Value of Tests
MH  - Proportional Hazards Models
MH  - Recurrence
MH  - Risk Assessment
MH  - Risk Factors
MH  - Stroke Volume
MH  - Time Factors
MH  - Ventricular Function, Left
OTO - NOTNLM
OT  - Cardiac magnetic resonance imaging
OT  - Microvascular obstruction
OT  - Non-invasive risk stratification
OT  - ST segment elevation myocardial infarction
OT  - t-wave alternans
EDAT- 2015/09/10 06:00
MHDA- 2016/09/08 06:00
CRDT- 2015/09/10 06:00
PHST- 2015/06/03 00:00 [received]
PHST- 2015/08/21 00:00 [accepted]
PHST- 2015/09/10 06:00 [entrez]
PHST- 2015/09/10 06:00 [pubmed]
PHST- 2016/09/08 06:00 [medline]
AID - 10.1007/s12265-015-9649-x [pii]
AID - 10.1007/s12265-015-9649-x [doi]
PST - ppublish
SO  - J Cardiovasc Transl Res. 2015 Nov;8(8):484-92. doi: 10.1007/s12265-015-9649-x. 
      Epub 2015 Sep 8.