PMID- 26350547
OWN - NLM
STAT- MEDLINE
DCOM- 20160317
LR  - 20200107
IS  - 1549-4713 (Electronic)
IS  - 0161-6420 (Print)
IS  - 0161-6420 (Linking)
VI  - 122
IP  - 12
DP  - 2015 Dec
TI  - Relationship between Human Immunodeficiency Virus Neuroretinal Disorder and 
      Vision-Specific Quality of Life among People with AIDS.
PG  - 2560-7
LID - S0161-6420(15)00776-9 [pii]
LID - 10.1016/j.ophtha.2015.07.037 [doi]
AB  - PURPOSE: Some human immunodeficiency virus (HIV)-infected individuals have 
      evidence of optic nerve or retinal dysfunction that manifests as decreased 
      contrast sensitivity, even with good best-corrected visual acuity (BCVA). This 
      condition, termed HIV-related neuroretinal disorder (HIV-NRD), is a risk factor 
      for vision impairment (BCVA <20/40), blindness (BCVA </=20/200), and increased 
      mortality. We investigated the effect of HIV-NRD on vision-specific quality of 
      life (QOL). DESIGN: Cross-sectional analysis of data from a prospective, 
      observational study. PARTICIPANTS: Individuals from the Longitudinal Study of the 
      Ocular Complications of AIDS cohort who completed the National Eye Institute 
      25-item Visual Function Questionnaire (VFQ-25), had BCVA of 20/40 or better, and 
      had no evidence of ocular opportunistic infection or cataract. METHODS: We 
      compared QOL by HIV-NRD status, adjusting for potential confounding variables, 
      using multiple linear regression. Among those with HIV-NRD, we assessed the 
      relationship between VFQ-25 and the logarithm of contrast sensitivity (logCS), 
      using Spearman correlation. We defined a minimum clinically important difference 
      (MCID) as 1 standard error of measurement from a well-characterized, historical 
      population of individuals with a variety of ophthalmic disorders. MAIN OUTCOME 
      MEASURES: Subscales and composite VFQ-25 scores (0 = worst, 100 = best). RESULTS: 
      A total of 813 individuals met study criteria. Those with HIV-NRD (n = 39 [4.8%]) 
      had a lower mean composite score than those without HIV-NRD (81 vs. 89; P = 
      0.0002) and lower mean scores in the following subscales: near activities (77 vs. 
      86; P = 0.004), distance activities (85 vs. 91; P = 0.01), social functioning (89 
      vs. 96; P = 0.0005), mental health (75 vs. 87; P = 0.0001), dependency (81 vs. 
      94; P < 0.0001), driving (75 vs. 85; P = 0.02), color vision (90 vs. 97; P < 
      0.0001), and peripheral vision (85 vs. 91; P = 0.0496). Score differences for 
      each of these subscales met criteria for MCID. Among those with HIV-NRD, there 
      was a positive correlation between logCS and composite score (r = 0.36; 95% 
      confidence interval, 0.04-0.60). CONCLUSIONS: HIV-NRD has a statistically 
      significant and clinically meaningful association with decreased vision-specific 
      QOL among people with AIDS and good BCVA.
CI  - Published by Elsevier Inc.
FAU - Ashraf, Davin C
AU  - Ashraf DC
AD  - Stein Eye Institute and the Department of Ophthalmology, David Geffen School of 
      Medicine at UCLA, University of California, Los Angeles, Los Angeles, California.
FAU - May, K Patrick
AU  - May KP
AD  - Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins 
      University, Baltimore, Maryland.
FAU - Holland, Gary N
AU  - Holland GN
AD  - Stein Eye Institute and the Department of Ophthalmology, David Geffen School of 
      Medicine at UCLA, University of California, Los Angeles, Los Angeles, California. 
      Electronic address: uveitis@jsei.ucla.edu.
FAU - Van Natta, Mark L
AU  - Van Natta ML
AD  - Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins 
      University, Baltimore, Maryland.
FAU - Wu, Albert W
AU  - Wu AW
AD  - Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins 
      University, Baltimore, Maryland; Department of Health Policy and Management, 
      Bloomberg School of Public Health, The Johns Hopkins University, Baltimore, 
      Maryland.
FAU - Thorne, Jennifer E
AU  - Thorne JE
AD  - The Wilmer Eye Institute and Department of Ophthalmology, The Johns Hopkins 
      University School of Medicine, Baltimore, Maryland.
FAU - Jabs, Douglas A
AU  - Jabs DA
AD  - Department of Epidemiology, Bloomberg School of Public Health, The Johns Hopkins 
      University, Baltimore, Maryland; Department of Ophthalmology, Icahn School of 
      Medicine at Mount Sinai, New York, New York; Department of Medicine, Icahn School 
      of Medicine at Mount Sinai, New York, New York.
CN  - Studies of the Ocular Complications of AIDS Research Group
LA  - eng
GR  - U10 EY 08052/EY/NEI NIH HHS/United States
GR  - U10 EY 08067/EY/NEI NIH HHS/United States
GR  - U10 EY008057/EY/NEI NIH HHS/United States
GR  - U10 EY 08057/EY/NEI NIH HHS/United States
GR  - U10 EY008052/EY/NEI NIH HHS/United States
GR  - U10 EY008067/EY/NEI NIH HHS/United States
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20150906
PL  - United States
TA  - Ophthalmology
JT  - Ophthalmology
JID - 7802443
SB  - IM
MH  - Acquired Immunodeficiency Syndrome/*psychology/virology
MH  - Adult
MH  - Contrast Sensitivity/physiology
MH  - Cross-Sectional Studies
MH  - Eye Infections, Viral/*psychology/virology
MH  - Female
MH  - HIV-1/pathogenicity
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Optic Nerve Diseases/*psychology/virology
MH  - Prospective Studies
MH  - Quality of Life/*psychology
MH  - Retinal Diseases/*psychology/virology
MH  - Sickness Impact Profile
MH  - Surveys and Questionnaires
MH  - Vision Disorders/*psychology
MH  - Visual Acuity/physiology
PMC - PMC6942692
MID - NIHMS1063991
EDAT- 2015/09/10 06:00
MHDA- 2016/03/18 06:00
PMCR- 2020/01/05
CRDT- 2015/09/10 06:00
PHST- 2015/04/15 00:00 [received]
PHST- 2015/07/28 00:00 [revised]
PHST- 2015/07/30 00:00 [accepted]
PHST- 2015/09/10 06:00 [entrez]
PHST- 2015/09/10 06:00 [pubmed]
PHST- 2016/03/18 06:00 [medline]
PHST- 2020/01/05 00:00 [pmc-release]
AID - S0161-6420(15)00776-9 [pii]
AID - 10.1016/j.ophtha.2015.07.037 [doi]
PST - ppublish
SO  - Ophthalmology. 2015 Dec;122(12):2560-7. doi: 10.1016/j.ophtha.2015.07.037. Epub 
      2015 Sep 6.