PMID- 2635066
OWN - NLM
STAT- MEDLINE
DCOM- 19900608
LR  - 20191029
IS  - 0303-6847 (Print)
IS  - 0303-6847 (Linking)
VI  - 26
IP  - 5
DP  - 1989
TI  - Caffeine-induced contraction in arteries from stroke-prone spontaneously 
      hypertensive rats.
PG  - 280-9
AB  - Differences in caffeine-induced contraction in smooth muscle of resistance 
      vessels from stroke-prone spontaneously hypertensive rats (SHRSP) and Wistar 
      Kyoto rats (WKY) were investigated by using mesenteric artery preparations. The 
      contraction induced by caffeine (10 mM) was greater in SHRSP preparations, both 
      in the presence and absence of Ca (10 min after Ca removal). Caffeine-induced 
      contraction was gradually decreased by the removal of extracellular Ca. No 
      significant difference was observed in the time course of the decay of the 
      contraction between SHRSP and WKY preparations, and the contraction disappeared 
      when the time in Ca-free solution exceeded 80 min. The contraction induced by 
      high-K-Tyrode's solution was completely abolished within 10 min after Ca removal, 
      both in SHRSP and WKY preparations. Caffeine-induced contraction could be blocked 
      by procaine or ryanodine. The results suggest that caffeine induces contraction 
      by releasing Ca from sarcoplasmic reticulum, and that the release of Ca is 
      greater in SHRSP vascular smooth muscle. It is also suggested that sarcoplasmic 
      reticulum is leaky for stored Ca when extracellular Ca is removed, and that the 
      rate of leakage does not differ between smooth muscle cells of SHRSP and WKY 
      mesenteric arteries.
FAU - Moriyama, K
AU  - Moriyama K
AD  - Research Institute of Hypertension, Kinki University, Osaka-Sayama, Japan.
FAU - Osugi, S
AU  - Osugi S
FAU - Shimamura, K
AU  - Shimamura K
FAU - Sunano, S
AU  - Sunano S
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Blood Vessels
JT  - Blood vessels
JID - 0427130
RN  - 15662-33-6 (Ryanodine)
RN  - 3G6A5W338E (Caffeine)
RN  - 4Z8Y51M438 (Procaine)
RN  - RWP5GA015D (Potassium)
RN  - SY7Q814VUP (Calcium)
SB  - IM
MH  - Animals
MH  - Blood Pressure
MH  - Body Weight
MH  - Caffeine/*pharmacology
MH  - Calcium/*physiology
MH  - Cerebrovascular Disorders/*physiopathology
MH  - Dose-Response Relationship, Drug
MH  - In Vitro Techniques
MH  - Mesenteric Arteries/drug effects
MH  - Muscle Contraction/*drug effects
MH  - Muscle, Smooth, Vascular/*drug effects
MH  - Potassium/pharmacology
MH  - Procaine/pharmacology
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Ryanodine/pharmacology
EDAT- 1989/01/01 00:00
MHDA- 1989/01/01 00:01
CRDT- 1989/01/01 00:00
PHST- 1989/01/01 00:00 [pubmed]
PHST- 1989/01/01 00:01 [medline]
PHST- 1989/01/01 00:00 [entrez]
AID - 10.1159/000158777 [doi]
PST - ppublish
SO  - Blood Vessels. 1989;26(5):280-9. doi: 10.1159/000158777.