PMID- 26350703
OWN - NLM
STAT- MEDLINE
DCOM- 20160624
LR  - 20181202
IS  - 1872-7123 (Electronic)
IS  - 0165-1781 (Linking)
VI  - 230
IP  - 2
DP  - 2015 Dec 15
TI  - Reversal of corticosterone-induced BDNF alterations by the natural antioxidant 
      alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the 
      neurotrophic hypothesis of depression.
PG  - 211-9
LID - S0165-1781(15)30255-9 [pii]
LID - 10.1016/j.psychres.2015.08.042 [doi]
AB  - Brain derived neurotrophic factor (BDNF) is linked to the pathophysiology of 
      depression. We hypothesized that BDNF is one of the neurobiological pathways 
      related to the augmentation effect of alpha-lipoic acid (ALA) when associated 
      with antidepressants. Female mice were administered vehicle or CORT 20mg/kg 
      during 14 days. From the 15th to 21st days the animals were divided in groups 
      that were further administered: vehicle, desvenlafaxine (DVS) 10 or 20mg/kg, ALA 
      100 or 200mg/kg or the combinations of DVS10+ALA100, DVS20+ALA100, DVS10+ALA200 
      or DVS20+ALA200. ALA or DVS alone or in combination reversed CORT-induced 
      increase in immobility time in the forced swimming test and decrease in sucrose 
      preference, presenting, thus, an antidepressant-like effect. DVS10 alone reversed 
      CORT-induced decrease in BDNF in the prefrontal cortex (PFC), hippocampus (HC) 
      and striatum (ST). The same was observed in the HC and ST of ALA200 treated 
      animals. The combination of DVS and ALA200 reversed CORT-induced alterations in 
      BDNF and even, in some cases, increased the levels of this neurotrophin when 
      compared to vehicle-treated animals in HC and ST. Taken together, these results 
      suggest that the combination of the DVS+ALA may be valuable for treating 
      conditions in which BDNF levels are decreased, such as depression.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - de Sousa, Caren Nadia Soares
AU  - de Sousa CN
AD  - Neuropsychopharmacology Laboratory, Department of Physiology and Pharmacology, 
      Federal University of Ceara, Fortaleza, Ceara, Brazil. Electronic address: 
      carensoarez@yahoo.com.br.
FAU - Meneses, Lucas Nascimento
AU  - Meneses LN
AD  - Neuropsychopharmacology Laboratory, Department of Physiology and Pharmacology, 
      Federal University of Ceara, Fortaleza, Ceara, Brazil. Electronic address: 
      lucasmeneses07@gmail.com.
FAU - Vasconcelos, Germana Silva
AU  - Vasconcelos GS
AD  - Neuropsychopharmacology Laboratory, Department of Physiology and Pharmacology, 
      Federal University of Ceara, Fortaleza, Ceara, Brazil. Electronic address: 
      germana_vasconcelos@yahoo.com.br.
FAU - Silva, Marcia Calheiros Chaves
AU  - Silva MC
AD  - Neuropsychopharmacology Laboratory, Department of Physiology and Pharmacology, 
      Federal University of Ceara, Fortaleza, Ceara, Brazil. Electronic address: 
      marciacalheiros@yahoo.com.br.
FAU - da Silva, Jessica Calheiros
AU  - da Silva JC
AD  - Federal University of Ceara, Fortaleza, Ceara, Brazil. Electronic address: 
      jessicacalheiros@hotmail.com.
FAU - Macedo, Danielle
AU  - Macedo D
AD  - Neuropsychopharmacology Laboratory, Department of Physiology and Pharmacology, 
      Federal University of Ceara, Fortaleza, Ceara, Brazil. Electronic address: 
      daniellesilmacedo@gmail.com.
FAU - de Lucena, David Freitas
AU  - de Lucena DF
AD  - Neuropsychopharmacology Laboratory, Department of Physiology and Pharmacology, 
      Federal University of Ceara, Fortaleza, Ceara, Brazil. Electronic address: 
      daviddelucena@me.com.
FAU - Vasconcelos, Silvania Maria Mendes
AU  - Vasconcelos SM
AD  - Neuropsychopharmacology Laboratory, Department of Physiology and Pharmacology, 
      Federal University of Ceara, Fortaleza, Ceara, Brazil. Electronic address: 
      silvania@pq.cnpq.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150901
PL  - Ireland
TA  - Psychiatry Res
JT  - Psychiatry research
JID - 7911385
RN  - 0 (Antidepressive Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 73Y7P0K73Y (Thioctic Acid)
RN  - W980KJ009P (Corticosterone)
RN  - ZB22ENF0XR (Desvenlafaxine Succinate)
SB  - IM
MH  - Animals
MH  - Antidepressive Agents/administration & dosage
MH  - Antioxidants/*administration & dosage
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Corticosterone/*pharmacology
MH  - Depression/drug therapy/*metabolism
MH  - Desvenlafaxine Succinate/*administration & dosage
MH  - Drug Therapy, Combination
MH  - Female
MH  - Hippocampus/drug effects/metabolism
MH  - Mice
MH  - Prefrontal Cortex/drug effects/metabolism
MH  - Swimming/physiology/psychology
MH  - Thioctic Acid/*administration & dosage
OTO - NOTNLM
OT  - Alpha-lipoic acid
OT  - BDNF
OT  - Corticosterone model of depression
OT  - Desvenlafaxine
OT  - Major depressive disorder
OT  - Treatment resistant depressive disorder
EDAT- 2015/09/10 06:00
MHDA- 2016/06/25 06:00
CRDT- 2015/09/10 06:00
PHST- 2015/01/20 00:00 [received]
PHST- 2015/08/11 00:00 [revised]
PHST- 2015/08/31 00:00 [accepted]
PHST- 2015/09/10 06:00 [entrez]
PHST- 2015/09/10 06:00 [pubmed]
PHST- 2016/06/25 06:00 [medline]
AID - S0165-1781(15)30255-9 [pii]
AID - 10.1016/j.psychres.2015.08.042 [doi]
PST - ppublish
SO  - Psychiatry Res. 2015 Dec 15;230(2):211-9. doi: 10.1016/j.psychres.2015.08.042. 
      Epub 2015 Sep 1.