PMID- 26351509
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150909
LR  - 20201001
IS  - 1741-427X (Print)
IS  - 1741-4288 (Electronic)
IS  - 1741-427X (Linking)
VI  - 2015
DP  - 2015
TI  - Studies on the Antifatigue Activities of Cordyceps militaris Fruit Body Extract 
      in Mouse Model.
PG  - 174616
LID - 10.1155/2015/174616 [doi]
LID - 174616
AB  - Cordyceps militaris has been used extensively as a crude drug and a folk tonic 
      food in East Asia due to its various pharmacological activities. Our study aims 
      to investigate the effect of Cordyceps militaris fruit body extract (CM) on 
      antifatigue in mouse model. Two week CM administration significantly delayed 
      fatigue phenomenon which is confirmed via rotating rod test, forced swimming test 
      and forced running test. Compared to nontreated mouse, CM administration 
      increased ATP levels and antioxidative enzymes activity and reduced the levels of 
      lactic acid, lactic dehydrogenase, malondialdehyde, and reactive oxygen species. 
      Further data suggests that CM-induced fatigue recovery is mainly through 
      activating 5'-AMP-activated protein kinase (AMPK) and protein kinase B 
      (AKT)/mammalian target of rapamycin (mTOR) pathways and regulating serum hormone 
      level. Moreover, CM-enhanced the phosphorylation of AMPK contributes to its 
      antioxidant effect. Our data provides experimental evidence in supporting 
      clinical use of CM as an effective agent against fatigue.
FAU - Song, Jingjing
AU  - Song J
AD  - College of Life Sciences, Jilin University, Changchun 130012, China.
FAU - Wang, Yingwu
AU  - Wang Y
AD  - College of Life Sciences, Jilin University, Changchun 130012, China.
FAU - Teng, Meiyu
AU  - Teng M
AD  - College of Life Sciences, Jilin University, Changchun 130012, China.
FAU - Cai, Guangsheng
AU  - Cai G
AD  - College of Life Sciences, Jilin University, Changchun 130012, China.
FAU - Xu, Hongkai
AU  - Xu H
AD  - College of Life Sciences, Jilin University, Changchun 130012, China.
FAU - Guo, Hanxiao
AU  - Guo H
AD  - College of Life Sciences, Jilin University, Changchun 130012, China.
FAU - Liu, Yang
AU  - Liu Y
AD  - College of Life Sciences, Jilin University, Changchun 130012, China.
FAU - Wang, Di
AU  - Wang D
AD  - College of Life Sciences, Jilin University, Changchun 130012, China.
FAU - Teng, Lesheng
AU  - Teng L
AD  - College of Life Sciences, Jilin University, Changchun 130012, China.
LA  - eng
PT  - Journal Article
DEP - 20150817
PL  - United States
TA  - Evid Based Complement Alternat Med
JT  - Evidence-based complementary and alternative medicine : eCAM
JID - 101215021
PMC - PMC4553310
EDAT- 2015/09/10 06:00
MHDA- 2015/09/10 06:01
PMCR- 2015/08/17
CRDT- 2015/09/10 06:00
PHST- 2015/03/03 00:00 [received]
PHST- 2015/06/04 00:00 [accepted]
PHST- 2015/09/10 06:00 [entrez]
PHST- 2015/09/10 06:00 [pubmed]
PHST- 2015/09/10 06:01 [medline]
PHST- 2015/08/17 00:00 [pmc-release]
AID - 10.1155/2015/174616 [doi]
PST - ppublish
SO  - Evid Based Complement Alternat Med. 2015;2015:174616. doi: 10.1155/2015/174616. 
      Epub 2015 Aug 17.