PMID- 2635244
OWN - NLM
STAT- MEDLINE
DCOM- 19900614
LR  - 20131121
IS  - 0023-2513 (Print)
IS  - 0023-2513 (Linking)
VI  - 35
IP  - 5-6
DP  - 1989 Dec
TI  - A study on the role of zinc on the immune response and body metabolism--a 
      contribution of trace elements.
PG  - 299-309
AB  - The role of zinc in the control of lymphocyte function, especially immune 
      response was studied. Zinc inhibited pokeweed mitogen (PWM)-induced generation of 
      immunoglobulin secreting cells (ISC) apparently by a non-specific activation of T 
      cells involving both CD4 and CD8 cells as well as both CD8-Leu8+ and CD8-Leu8- 
      cells. Lymphocyte proliferation was inhibited by anti-IL2 receptor and anti-IL2 
      antibodies as well, indicating that zinc augments signal transduction through IL2 
      receptors through enhancement of the interaction between the IL2 and IL2 
      receptors. Zinc induced high affinity receptors for IL2 on lymphocytes.
FAU - Tanaka, Y
AU  - Tanaka Y
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Kobe J Med Sci
JT  - The Kobe journal of medical sciences
JID - 0413531
RN  - 0 (Interleukin-2)
RN  - 0 (Receptors, Interleukin-2)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Antibody-Producing Cells/immunology
MH  - Cells, Cultured
MH  - Humans
MH  - Interleukin-2/metabolism
MH  - Lymphocyte Activation/*drug effects
MH  - Receptors, Interleukin-2/drug effects/metabolism
MH  - T-Lymphocytes/*immunology/metabolism
MH  - Zinc/*pharmacology
EDAT- 1989/12/01 00:00
MHDA- 1989/12/01 00:01
CRDT- 1989/12/01 00:00
PHST- 1989/12/01 00:00 [pubmed]
PHST- 1989/12/01 00:01 [medline]
PHST- 1989/12/01 00:00 [entrez]
PST - ppublish
SO  - Kobe J Med Sci. 1989 Dec;35(5-6):299-309.