PMID- 26352548
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1538-7151 (Electronic)
IS  - 0277-1691 (Linking)
VI  - 35
IP  - 2
DP  - 2016 Mar
TI  - Value of PAX-8 and SF-1 Immunohistochemistry in the Distinction Between Female 
      Adnexal Tumor of Probable Wolffian Origin and its Mimics.
PG  - 167-75
LID - 10.1097/PGP.0000000000000222 [doi]
AB  - Female adnexal tumors of probable wolffian origin (FATWOs) are rare. They can 
      closely mimic endometrioid adenocarcinomas with a prominent spindle cell 
      component and Sertoli cell tumors (SCTs). To further define their 
      immunohistochemical profile and origin, we investigated the expression of PAX-8, 
      PAX-2, and GATA binding protein 3 (GATA-3) (wolffian markers) and of 
      steroidogenic factor-1 (SF-1) (sex-cord stromal marker) in FATWOs. We also 
      studied the expression of PAX-8 and PAX-2 in endometrioid adenocarcinomas; of 
      SF-1 in Sertoli-Leydig cell and SCTs; and of PAX-8, PAX-2, GATA-3, and SF-1 in 
      rete ovarii-a proposed site of origin for FATWOs. A database search yielded 8 
      FATWOs, 18 ovarian/tubal/paraovarian endometrioid adenocarcinomas, and 8 ovarian 
      Sertoli-Leydig cell and SCTs. Eleven cases with rete ovarii sections were 
      included. Of the FATWOs studied, all were negative for PAX-8, PAX-2, GATA-3, and 
      SF-1. Of the endometrioid adenocarcinomas studied, PAX-8 was positive in all and 
      PAX-2 was positive in 57%. Of the Sertoli-Leydig cell and SCTs, all were positive 
      for SF-1 except one. The rete ovarii were positive for PAX-8, weakly positive for 
      SF-1, and negative for PAX-2 and GATA-3. Our study suggests that PAX-8 and SF-1 
      can be helpful in the distinction between FATWOs and endometrioid adenocarcinomas 
      and SCTs, respectively. Our results do not support a Mullerian or sex-cord 
      stromal or rete ovarii origin for FATWOs. It is curious, however, that FATWOs do 
      not express wolffian markers-it is possibly related to their origin from a 
      distinctive portion of the wolffian duct.
FAU - Goyal, Abha
AU  - Goyal A
AD  - Cleveland Clinic (A.G., A.A.R.), Cleveland, Ohio Department of Pathology & 
      Immunology (R.P.M.), Baylor College of Medicine, Houston, Texas.
FAU - Masand, Ramya P
AU  - Masand RP
FAU - Roma, Andres A
AU  - Roma AA
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Gynecol Pathol
JT  - International journal of gynecological pathology : official journal of the 
      International Society of Gynecological Pathologists
JID - 8214845
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (PAX8 Transcription Factor)
RN  - 0 (PAX8 protein, human)
RN  - 0 (Steroidogenic Factor 1)
RN  - Wolffian tumor
SB  - IM
MH  - Adenoma/*diagnosis
MH  - Adnexal Diseases/*diagnosis
MH  - Adult
MH  - Biomarkers, Tumor/*analysis
MH  - Carcinoma, Endometrioid/diagnosis
MH  - *Diagnosis, Differential
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - Middle Aged
MH  - PAX8 Transcription Factor/analysis/*biosynthesis
MH  - Sertoli Cell Tumor/diagnosis
MH  - Steroidogenic Factor 1/analysis/*biosynthesis
EDAT- 2015/09/10 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/09/10 06:00
PHST- 2015/09/10 06:00 [entrez]
PHST- 2015/09/10 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1097/PGP.0000000000000222 [doi]
PST - ppublish
SO  - Int J Gynecol Pathol. 2016 Mar;35(2):167-75. doi: 10.1097/PGP.0000000000000222.