PMID- 26354040
OWN - NLM
STAT- MEDLINE
DCOM- 20160414
LR  - 20191210
IS  - 1520-6882 (Electronic)
IS  - 0003-2700 (Linking)
VI  - 87
IP  - 19
DP  - 2015 Oct 6
TI  - Novel analytical approach for brominated flame retardants based on the use of gas 
      chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry 
      with emphasis in highly brominated congeners.
PG  - 9892-9
LID - 10.1021/acs.analchem.5b02378 [doi]
AB  - The analysis of brominated flame retardants (BFRs) commonly relies on the use of 
      gas chromatography coupled to mass spectrometry (GC-MS) operating in electron 
      ionization (EI) and electron capture negative ionization (ECNI) modes using 
      quadrupole, triple quadrupole, ion trap, and magnetic sector analyzers. However, 
      these brominated contaminants are examples of compounds for which a soft and 
      robust ionization technique might be favorable since they show high fragmentation 
      in EI and low specificity in ECNI. In addition, the low limits of quantification 
      (0.01 ng/g) required by European Commission Recommendation 2014/118/EU on the 
      monitoring of traces of BFRs in food put stress on the use of highly sensitive 
      techniques/methods. In this work, a new approach for the extremely sensitive 
      determination of BFRs taking profit of the potential of atmospheric pressure 
      chemical ionization (APCI) combined with GC and triple quadrupole (QqQ) mass 
      analyzer is proposed. The objective was to explore the potential of this approach 
      for the BFRs determination in samples at pg/g levels, taking marine samples and a 
      cream sample as a model. Ionization and fragmentation behavior of 14 PBDEs 
      (congeners 28, 47, 66, 85, 99, 100, 153, 154, 183, 184, 191, 196, 197, and 209) 
      and two novel BFRs, decabromodiphenyl ethane (DBDPE) and 
      1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), in the GC-APCI-MS system has been 
      investigated. The formation of highly abundant (quasi) molecular ion was the main 
      advantage observed in relation to EI. Thus, a notable improvement in sensitivity 
      and specificity was observed when using it as precursor ion in tandem MS. The 
      improved detectability (LODs < 10 fg) achieved when using APCI compared to EI has 
      been demonstrated, which is especially relevant for highly brominated congeners. 
      Analysis of samples from an intercomparison exercise and samples from the marine 
      field showed the potential of this approach for the reliable identification and 
      quantification at very low concentration levels.
FAU - Portoles, Tania
AU  - Portoles T
AD  - Research Institute for Pesticides and Water, University Jaume I , 12071 
      Castellon, Spain.
FAU - Sales, Carlos
AU  - Sales C
AD  - Research Institute for Pesticides and Water, University Jaume I , 12071 
      Castellon, Spain.
FAU - Gomara, Belen
AU  - Gomara B
AD  - Institute of General Organic Chemistry, CSIC , Madrid, Spain.
FAU - Sancho, Juan Vicente
AU  - Sancho JV
AD  - Research Institute for Pesticides and Water, University Jaume I , 12071 
      Castellon, Spain.
FAU - Beltran, Joaquim
AU  - Beltran J
AD  - Research Institute for Pesticides and Water, University Jaume I , 12071 
      Castellon, Spain.
FAU - Herrero, Laura
AU  - Herrero L
AD  - Institute of General Organic Chemistry, CSIC , Madrid, Spain.
FAU - Gonzalez, Maria Jose
AU  - Gonzalez MJ
AD  - Institute of General Organic Chemistry, CSIC , Madrid, Spain.
FAU - Hernandez, Felix
AU  - Hernandez F
AD  - Research Institute for Pesticides and Water, University Jaume I , 12071 
      Castellon, Spain.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150930
PL  - United States
TA  - Anal Chem
JT  - Analytical chemistry
JID - 0370536
RN  - 0 (Bromobenzenes)
RN  - 0 (Flame Retardants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (decabromodiphenyl ethane)
RN  - 34I00D6RNM (1,2-bis(2,4,6-tribromophenoxy)ethane)
SB  - IM
MH  - Animals
MH  - Bromobenzenes/*analysis
MH  - Environmental Monitoring/instrumentation/*methods
MH  - Equipment Design
MH  - Fishes/metabolism
MH  - Flame Retardants/*analysis
MH  - Gas Chromatography-Mass Spectrometry/instrumentation/*methods
MH  - Halogenated Diphenyl Ethers/*analysis
MH  - Limit of Detection
MH  - Reproducibility of Results
MH  - Tandem Mass Spectrometry/instrumentation/methods
EDAT- 2015/09/12 06:00
MHDA- 2016/04/15 06:00
CRDT- 2015/09/11 06:00
PHST- 2015/09/11 06:00 [entrez]
PHST- 2015/09/12 06:00 [pubmed]
PHST- 2016/04/15 06:00 [medline]
AID - 10.1021/acs.analchem.5b02378 [doi]
PST - ppublish
SO  - Anal Chem. 2015 Oct 6;87(19):9892-9. doi: 10.1021/acs.analchem.5b02378. Epub 2015 
      Sep 30.