PMID- 26354738
OWN - NLM
STAT- MEDLINE
DCOM- 20170104
LR  - 20170105
IS  - 1477-111X (Electronic)
IS  - 0267-6591 (Linking)
VI  - 31
IP  - 4
DP  - 2016 May
TI  - PRIS may be diagnosed before ICU period for patients undergoing cardiopulmonary 
      bypass.
PG  - 281-7
LID - 10.1177/0267659115604708 [doi]
AB  - There are many published articles on the clinical manifestations of 
      propofol-related infusion syndrome (PRIS), but they are not the same in each 
      case.(1)Moreover, PRIS is only encountered infrequently and, therefore, it may 
      create a diagnostic challenge. Nearly all of the published articles on PRIS are 
      related to the use of long-term (> 48 hour) propofol infusion with a dose range 
      of at least 4-5 mg/kg/h. In this case, not only a short duration, but also a 
      low-dose propofol administration seems to induce PRIS. A 73-year-old male patient 
      under cardiopulmonary bypass (CPB) suffered from some clinical symptoms of PRIS, 
      such as hyperlactatemia and persistent low metabolic acidosis which promptly 
      resolved on the discontinuation of propofol. Therefore, we suggest that any 
      propofol administration (bolus or infusion) may result in such clinical symptoms, 
      which may be the earliest indicators of PRIS. When those symptoms are observed on 
      propofol administration during cardiopulmonary bypass (CPB), the perfusionist 
      must alert both the anaesthesiologist and the surgeon to stop the propofol in 
      order to prevent the patient from further adverse effects of PRIS.
CI  - (c) The Author(s) 2015.
FAU - Sahin, Turker
AU  - Sahin T
AD  - Near East University Hospital, Perfusion Services, Nicosia, Northern Cyprus, 
      Turkey turkersahin@lycos.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20150909
PL  - England
TA  - Perfusion
JT  - Perfusion
JID - 8700166
RN  - YI7VU623SF (Propofol)
SB  - IM
MH  - Aged
MH  - *Cardiopulmonary Bypass
MH  - Humans
MH  - *Intensive Care Units
MH  - Male
MH  - Propofol/administration & dosage/*adverse effects
MH  - Propofol Infusion Syndrome/*diagnosis/*therapy
OTO - NOTNLM
OT  - CPB
OT  - PRIS
OT  - propofol
EDAT- 2015/09/12 06:00
MHDA- 2017/01/05 06:00
CRDT- 2015/09/11 06:00
PHST- 2015/09/11 06:00 [entrez]
PHST- 2015/09/12 06:00 [pubmed]
PHST- 2017/01/05 06:00 [medline]
AID - 0267659115604708 [pii]
AID - 10.1177/0267659115604708 [doi]
PST - ppublish
SO  - Perfusion. 2016 May;31(4):281-7. doi: 10.1177/0267659115604708. Epub 2015 Sep 9.