PMID- 26355496
OWN - NLM
STAT- MEDLINE
DCOM- 20161024
LR  - 20181113
IS  - 1096-9861 (Electronic)
IS  - 0021-9967 (Print)
IS  - 0021-9967 (Linking)
VI  - 524
IP  - 5
DP  - 2016 Apr 1
TI  - Sex and age differences in brain-derived neurotrophic factor and vimentin in the 
      zebra finch song system: Relationships to newly generated cells.
PG  - 1081-96
LID - 10.1002/cne.23893 [doi]
AB  - The neural song circuit is enhanced in male compared with female zebra finches 
      due to differential rates of incorporation and survival of cells between the 
      sexes. Two double-label immunohistochemical experiments were conducted to 
      increase the understanding of relationships between newly generated cells (marked 
      with bromodeoxyuridine [BrdU]) and those expressing brain-derived neurotrophic 
      factor (BDNF) and vimentin, a marker for radial glia. The song systems of males 
      and females were investigated at posthatching day 25 during a heightened period 
      of sexual differentiation (following BrdU injections on days 6-10) and in 
      adulthood (following a parallel injection paradigm). In both HVC (proper name) 
      and the robust nucleus of the arcopallium (RA), about half of the BrdU-positive 
      cells expressed BDNF across sexes and ages. Less than 10% of the BDNF-positive 
      cells expressed BrdU, but this percentage was greater in juveniles than adults. 
      Across both brain regions, more BDNF-positive cells were detected in males 
      compared with females. In RA, the number of these cells was also greater in 
      juveniles than adults. In HVC, the average cross-sectional area covered by the 
      vimentin labeling was greater in males than females and in juveniles compared 
      with adults. In RA, more vimentin was detected in juveniles than adults, and 
      within adults it was greater in females. In juveniles only, BrdU-positive cells 
      appeared in contact with vimentin-labeled fibers in HVC, RA, and Area X. 
      Collectively, the results are consistent with roles of BDNF- and vimentin-labeled 
      cells influencing sexually differentiated plasticity of the song circuit.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Tang, Yu Ping
AU  - Tang YP
AD  - Department of Psychology, Michigan State University, East Lansing, Michigan, 
      48824.
FAU - Wade, Juli
AU  - Wade J
AD  - Neuroscience Program, Michigan State University, East Lansing, Michigan, 48824.
LA  - eng
GR  - R01 MH096705/MH/NIMH NIH HHS/United States
GR  - R01-MH096705/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20151015
PL  - United States
TA  - J Comp Neurol
JT  - The Journal of comparative neurology
JID - 0406041
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Vimentin)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Brain/cytology/*metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Female
MH  - Finches
MH  - Humans
MH  - Male
MH  - Neurogenesis/*physiology
MH  - *Sex Characteristics
MH  - Vimentin/*metabolism
MH  - Vocalization, Animal/*physiology
PMC - PMC4731248
MID - NIHMS721891
OTO - NOTNLM
OT  - AB_514483
OT  - AB_528504
OT  - AB_630940
OT  - neurogenesis
OT  - radial glia
OT  - sexual differentiation
OT  - songbird
EDAT- 2015/09/12 06:00
MHDA- 2016/10/25 06:00
PMCR- 2017/04/01
CRDT- 2015/09/11 06:00
PHST- 2015/06/16 00:00 [received]
PHST- 2015/08/21 00:00 [revised]
PHST- 2015/08/26 00:00 [accepted]
PHST- 2015/09/11 06:00 [entrez]
PHST- 2015/09/12 06:00 [pubmed]
PHST- 2016/10/25 06:00 [medline]
PHST- 2017/04/01 00:00 [pmc-release]
AID - 10.1002/cne.23893 [doi]
PST - ppublish
SO  - J Comp Neurol. 2016 Apr 1;524(5):1081-96. doi: 10.1002/cne.23893. Epub 2015 Oct 
      15.