PMID- 26355638
OWN - NLM
STAT- MEDLINE
DCOM- 20160906
LR  - 20211203
IS  - 1097-4598 (Electronic)
IS  - 0148-639X (Linking)
VI  - 53
IP  - 5
DP  - 2016 May
TI  - High-intensity resistance training attenuates dexamethasone-induced muscle 
      atrophy.
PG  - 779-88
LID - 10.1002/mus.24906 [doi]
AB  - INTRODUCTION: In this study we investigated the effects of high-intensity 
      resistance training (RT) on dexamethasone (DEX)-induced muscle atrophy in flexor 
      hallucis longus (FHL), tibialis anterior (TA), and soleus (SOL) muscles. METHODS: 
      Rats underwent either high-intensity RT or were kept sedentary. In the last 10 
      days they received either DEX (0.5 mg/kg/day, intraperitoneally) or saline. 
      RESULTS: DEX reduced body weight (-21%), food intake (-28%), FHL and TA muscle 
      mass (-20% and -18%, respectively), and increased muscle-specific ring finger 1 
      (MuRF-1) protein level (+37% and +45.5%). RT attenuated FHL muscle atrophy 
      through a combination of low increase in MuRF-1 protein level (-3.5%) and 
      significant increases in mammalian target of rapamycin (mTOR) (+63%) and p70S6K 
      (+46% and +49% for control and DEX, respectively) protein levels. CONCLUSION: RT 
      attenuated DEX-induced muscle atrophy through a combination of increases in mTOR 
      and p70S6K protein levels and a low increase in MuRF-1 protein level.
CI  - (c) 2016 Wiley Periodicals, Inc.
FAU - Krug, Andre L O
AU  - Krug AL
AD  - Joint Graduate Program in Physiological Sciences, PIPGCF UFscar/UNESP, Federal 
      University of Sao Carlos/Sao Paulo State University, Sao Carlos, Sao Paulo, 
      Brazil.
FAU - Macedo, Anderson G
AU  - Macedo AG
AD  - Joint Graduate Program in Physiological Sciences, PIPGCF UFscar/UNESP, Federal 
      University of Sao Carlos/Sao Paulo State University, Sao Carlos, Sao Paulo, 
      Brazil.
FAU - Zago, Anderson S
AU  - Zago AS
AD  - Department of Physical Education, Science Faculty, Sao Paulo State University, 
      Avenida Eng. Luiz Edmundo Carrijo Coube, 14-01, Vargem Limpa, Bauru, Sao Paulo, 
      Brazil.
FAU - Rush, James W E
AU  - Rush JW
AD  - Department of Kinesiology, Faculty of Applied Health Sciences, University of 
      Waterloo, Waterloo, Ontario, Canada.
FAU - Santos, Carlos F
AU  - Santos CF
AD  - Department of Biological Sciences, Bauru School of Dentistry, University of Sao 
      Paulo, Bauru, Sao Paulo, Brazil.
FAU - Amaral, Sandra L
AU  - Amaral SL
AD  - Joint Graduate Program in Physiological Sciences, PIPGCF UFscar/UNESP, Federal 
      University of Sao Carlos/Sao Paulo State University, Sao Carlos, Sao Paulo, 
      Brazil.
AD  - Department of Physical Education, Science Faculty, Sao Paulo State University, 
      Avenida Eng. Luiz Edmundo Carrijo Coube, 14-01, Vargem Limpa, Bauru, Sao Paulo, 
      Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20160328
PL  - United States
TA  - Muscle Nerve
JT  - Muscle & nerve
JID - 7803146
RN  - 0 (Glucocorticoids)
RN  - 0 (Muscle Proteins)
RN  - 0 (Tripartite Motif Proteins)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - EC 2.3.2.27 (Trim63 protein, rat)
RN  - EC 2.3.2.27 (Ubiquitin-Protein Ligases)
RN  - EC 2.7.1.1 (mTOR protein, rat)
RN  - EC 2.7.11.1 (Ribosomal Protein S6 Kinases, 70-kDa)
RN  - EC 2.7.11.1 (TOR Serine-Threonine Kinases)
SB  - IM
MH  - Animals
MH  - Blotting, Western
MH  - Body Weight/drug effects
MH  - Dexamethasone/adverse effects/*pharmacology
MH  - Feeding Behavior/drug effects
MH  - Glucocorticoids/adverse effects/*pharmacology
MH  - Muscle Proteins/drug effects/metabolism
MH  - Muscle, Skeletal/*drug effects/metabolism/pathology
MH  - Muscular Atrophy/metabolism/*prevention & control
MH  - Organ Size/drug effects
MH  - Physical Conditioning, Animal/*methods
MH  - Rats
MH  - Resistance Training/*methods
MH  - Ribosomal Protein S6 Kinases, 70-kDa/drug effects/metabolism
MH  - TOR Serine-Threonine Kinases/drug effects/metabolism
MH  - Tripartite Motif Proteins
MH  - Ubiquitin-Protein Ligases/drug effects/metabolism
OTO - NOTNLM
OT  - glucocorticoids
OT  - ladder climbing
OT  - muscle atrophy
OT  - resistance training
OT  - skeletal muscle
EDAT- 2015/09/12 06:00
MHDA- 2016/09/07 06:00
CRDT- 2015/09/11 06:00
PHST- 2015/02/27 00:00 [received]
PHST- 2015/09/02 00:00 [revised]
PHST- 2015/09/09 00:00 [accepted]
PHST- 2015/09/11 06:00 [entrez]
PHST- 2015/09/12 06:00 [pubmed]
PHST- 2016/09/07 06:00 [medline]
AID - 10.1002/mus.24906 [doi]
PST - ppublish
SO  - Muscle Nerve. 2016 May;53(5):779-88. doi: 10.1002/mus.24906. Epub 2016 Mar 28.