PMID- 26358342
OWN - NLM
STAT- MEDLINE
DCOM- 20160614
LR  - 20150911
IS  - 1945-8932 (Electronic)
IS  - 1945-8932 (Linking)
VI  - 29
IP  - 5
DP  - 2015 Sep-Oct
TI  - Serum indolamine 2,3 dioxygenase as a marker in the evaluation of allergic 
      rhinitis.
PG  - 329-33
LID - 10.2500/ajra.2015.29.4210 [doi]
AB  - BACKGROUND: Allergic rhinitis occurs on exposure to a known allergen and is 
      correlated with a positive skin test and physical examination results. Tryptophan 
      is a substrate of many important proteins, e.g., indolamine 2,3 dioxygenase 
      (IDO). IDO, an immunomodulator, is a metabolic enzyme induced by immune 
      activation. It has a significant role in allergic reactions. T-helper 2 cell is 
      proposed to affect the expression of IDO. AIM: To evaluate IDO levels in patients 
      with allergic rhinitis compared with controls and its relationship to the 
      severity of allergic rhinitis. METHODS: This case-control study included 20 
      patients who were atopic and with allergic rhinitis who attended the allergy 
      clinic of Ain Shams University Hospitals. Twenty age- and sex-matched patients 
      who were not atopic were included as controls. An allergic rhinitis diagnosis was 
      made according to the Allergic Rhinitis and its Impact on Asthma document. 
      Complete history taking, physical examination, skin-prick test, complete blood 
      cell count, erythrocyte sedimentation rate, total serum immunoglobulin E (IgE), 
      IDO concentration, and nasal smear for eosinophils were done for the patients. 
      RESULTS: There was a significant increase in IDO levels in allergic rhinitis in 
      comparison with subjects without allergy (p < 0.001). IDO was positively 
      correlated with total IgE levels (p < 0.037). There was an insignificant 
      relationship among IDO levels and age, sex, duration of the disease, severity 
      score, nasal and blood eosinophilia, and number of positive allergens. 
      CONCLUSION: IDO plays an important role in patients with atopic symptomatic 
      allergic rhinitis, especially with increased levels of IgE. There is no 
      relationship between IDO levels and severity of disease.
FAU - Refaat, Maged Mohamed
AU  - Refaat MM
AD  - Department of Internal Medicine, Allergy and Clinical Inmmunology, Ain Shams 
      University, Cairo, Egypt.
FAU - Abdel Rehim, Asmaa Saber Mostafa
AU  - Abdel Rehim AS
FAU - El-Sayed, Hoda Mohammed
AU  - El-Sayed HM
FAU - Mohamed, Nesrine Aly
AU  - Mohamed NA
FAU - Khafagy, Ahmed Gamal
AU  - Khafagy AG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Rhinol Allergy
JT  - American journal of rhinology & allergy
JID - 101490775
RN  - 0 (Biomarkers)
RN  - 0 (Indoleamine-Pyrrole 2,3,-Dioxygenase)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Humans
MH  - *Immunity, Cellular
MH  - Immunoglobulin E/blood
MH  - Indoleamine-Pyrrole 2,3,-Dioxygenase/*blood
MH  - Male
MH  - Rhinitis, Allergic/*enzymology/immunology
MH  - Skin Tests
MH  - T-Lymphocytes, Helper-Inducer/*immunology
EDAT- 2015/09/12 06:00
MHDA- 2016/06/15 06:00
CRDT- 2015/09/12 06:00
PHST- 2015/09/12 06:00 [entrez]
PHST- 2015/09/12 06:00 [pubmed]
PHST- 2016/06/15 06:00 [medline]
AID - 10.2500/ajra.2015.29.4210 [doi]
PST - ppublish
SO  - Am J Rhinol Allergy. 2015 Sep-Oct;29(5):329-33. doi: 10.2500/ajra.2015.29.4210.