PMID- 26360329
OWN - NLM
STAT- MEDLINE
DCOM- 20151224
LR  - 20150924
IS  - 1365-2052 (Electronic)
IS  - 0268-9146 (Linking)
VI  - 46
IP  - 5
DP  - 2015 Oct
TI  - Association of TLR4 polymorphisms with Mycobacterium avium subspecies 
      paratuberculosis infection status in Canadian Holsteins.
PG  - 560-5
LID - 10.1111/age.12333 [doi]
AB  - Mycobacterium avium ssp. paratuberculosis (MAP) causes chronic enteritis in 
      cattle that results in substantial financial losses to the cattle industry 
      worldwide. Given that susceptibility to MAP infection is determined in part by 
      genetics, marker-assisted selection may help in the breeding of animals that are 
      more resistant to MAP infection. The toll-like receptor 4 gene (TLR4) was 
      selected as a potential candidate gene because of its role in innate immunity and 
      its involvement in MAP recognition and infection. The objective of this study, 
      therefore, was to identify associations between TLR4 polymorphisms and 
      susceptibility to MAP infection in Canadian Holstein cows. Two biologically 
      relevant SNPs, including c.-226G>C in the 5'-untranslated region and the 
      non-synonymous SNP c.2021C>T in the potential TIR domain, were selected for an 
      association analysis with MAP infection status in 409 Canadian Holsteins. The 
      haplotype C-T from these combined SNPs yielded significant association with 
      susceptibility to MAP infection, supporting the involvement of TLR4 in 
      susceptibility to MAP infection.
CI  - (c) 2015 Stichting International Foundation for Animal Genetics.
FAU - Sharma, B S
AU  - Sharma BS
AD  - Animal and Poultry Science, University of Guelph, 50 Stone Road East, Guelph, 
      Ontario, N1G 2W1, Canada.
FAU - Abo-Ismail, M K
AU  - Abo-Ismail MK
AD  - Animal and Poultry Science, University of Guelph, 50 Stone Road East, Guelph, 
      Ontario, N1G 2W1, Canada.
AD  - Department of Animal and Poultry Science, Damanhour University, Damanhour, Egypt.
FAU - Schenkel, F S
AU  - Schenkel FS
AD  - Animal and Poultry Science, University of Guelph, 50 Stone Road East, Guelph, 
      Ontario, N1G 2W1, Canada.
FAU - You, Q
AU  - You Q
AD  - Animal and Poultry Science, University of Guelph, 50 Stone Road East, Guelph, 
      Ontario, N1G 2W1, Canada.
FAU - Verschoor, C P
AU  - Verschoor CP
AD  - Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
FAU - Pant, S D
AU  - Pant SD
AD  - Animal and Veterinary Sciences, Charles Sturt University, Wagga Wagga, Australia.
FAU - Karrow, N A
AU  - Karrow NA
AD  - Animal and Poultry Science, University of Guelph, 50 Stone Road East, Guelph, 
      Ontario, N1G 2W1, Canada.
LA  - eng
PT  - Journal Article
DEP - 20150911
PL  - England
TA  - Anim Genet
JT  - Animal genetics
JID - 8605704
RN  - 0 (Genetic Markers)
RN  - 0 (Toll-Like Receptor 4)
SB  - IM
MH  - Animals
MH  - Canada
MH  - Cattle
MH  - Cattle Diseases/*genetics/microbiology
MH  - Female
MH  - Gene Frequency
MH  - Genetic Markers
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - Haplotypes
MH  - Linkage Disequilibrium
MH  - Models, Genetic
MH  - *Mycobacterium avium subsp. paratuberculosis
MH  - Paratuberculosis/*genetics
MH  - Polymorphism, Genetic
MH  - Polymorphism, Single Nucleotide
MH  - Toll-Like Receptor 4/*genetics
OTO - NOTNLM
OT  - Johne's disease
OT  - SNP
OT  - bovine
OT  - toll-like receptor 4
EDAT- 2015/09/12 06:00
MHDA- 2015/12/25 06:00
CRDT- 2015/09/12 06:00
PHST- 2015/06/22 00:00 [accepted]
PHST- 2015/09/12 06:00 [entrez]
PHST- 2015/09/12 06:00 [pubmed]
PHST- 2015/12/25 06:00 [medline]
AID - 10.1111/age.12333 [doi]
PST - ppublish
SO  - Anim Genet. 2015 Oct;46(5):560-5. doi: 10.1111/age.12333. Epub 2015 Sep 11.