PMID- 26361747
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20161230
IS  - 1532-2971 (Electronic)
IS  - 1090-0233 (Linking)
VI  - 206
IP  - 2
DP  - 2015 Nov
TI  - An analysis of the relative frequencies of reported adverse events associated 
      with NSAID administration in dogs and cats in the United Kingdom.
PG  - 183-90
LID - S1090-0233(15)00316-0 [pii]
LID - 10.1016/j.tvjl.2015.07.025 [doi]
AB  - This study aimed to analyse UK pharmacovigilance data to quantify adverse events 
      (AEs) associated with the non-steroidal anti-inflammatory drug (NSAID) molecules 
      found in veterinary medicines authorised for use in dogs and cats. It was 
      hypothesised that the frequency of AEs would be lower when associated with 
      cyclo-oxygenase-2 selective (coxib), compared to non-selective (non-coxib) 
      NSAIDs. The UK Veterinary Medicines Directorate (VMD) supplied frequencies of AEs 
      derived from Periodic Safety Update Reports subdivided by formulation and species 
      for each NSAID molecule. Frequencies of AEs were similar between species. The 
      five most reported AEs were emesis, death, anorexia, lethargy, and diarrhoea. 
      Reported frequency of emesis, renal insufficiency and death was higher with 
      injectable compared to oral NSAIDs (P = 0.043). Reported frequency of emesis, 
      lethargy and death was higher with coxib, compared to non-coxib NSAIDs 
      (P = 0.029). Median (range) interval since authorisation was shorter for coxibs 
      at 5 (2.5-9) years compared to non-coxibs at 15 (12-25) years. A negative 
      correlation between time elapsed since authorisation and the frequency of AEs was 
      identified (rs = -0.11 to -0.94). Higher frequency of reported AEs with 
      injectable NSAIDs may be related to perioperative administration. The AE 
      frequency associated with coxib and non-coxib NSAIDs may be confounded by changes 
      in reporting habits over time. This study highlights the value of interrogating 
      passive surveillance data to identify low frequency AEs and the need to 
      facilitate improvement in recording and collecting AEs in small animal practice.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Hunt, James R
AU  - Hunt JR
AD  - University of Bristol, School of Veterinary Sciences, Langford BS40 5DU, UK. 
      Electronic address: lvjrh@bris.ac.uk.
FAU - Dean, Rachel S
AU  - Dean RS
AD  - Centre for Evidence-based Veterinary Medicine, School of Veterinary Medicine and 
      Science, The University of Nottingham, Sutton Bonington Campus, Leicestershire 
      LE12 5RD, UK.
FAU - Davis, Giles N D
AU  - Davis GN
AD  - Pharmacovigilance Unit, Veterinary Medicines Directorate, Woodham Lane, New Haw, 
      Addlestone, Surrey KT15 3LS, UK.
FAU - Murrell, Joanna C
AU  - Murrell JC
AD  - University of Bristol, School of Veterinary Sciences, Langford BS40 5DU, UK.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150729
PL  - England
TA  - Vet J
JT  - Veterinary journal (London, England : 1997)
JID - 9706281
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/*adverse effects/classification
MH  - Cat Diseases/*chemically induced/epidemiology
MH  - Cats
MH  - Dog Diseases/*chemically induced/epidemiology
MH  - Dogs
MH  - Species Specificity
MH  - United Kingdom/epidemiology
OTO - NOTNLM
OT  - Adverse event
OT  - Cat
OT  - Dog
OT  - NSAID
OT  - Pharmacovigilance
EDAT- 2015/09/13 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/09/13 06:00
PHST- 2015/05/14 00:00 [received]
PHST- 2015/07/21 00:00 [revised]
PHST- 2015/07/23 00:00 [accepted]
PHST- 2015/09/13 06:00 [entrez]
PHST- 2015/09/13 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - S1090-0233(15)00316-0 [pii]
AID - 10.1016/j.tvjl.2015.07.025 [doi]
PST - ppublish
SO  - Vet J. 2015 Nov;206(2):183-90. doi: 10.1016/j.tvjl.2015.07.025. Epub 2015 Jul 29.