PMID- 26361959
OWN - NLM
STAT- MEDLINE
DCOM- 20170131
LR  - 20181113
IS  - 1423-0380 (Electronic)
IS  - 1010-4283 (Linking)
VI  - 37
IP  - 2
DP  - 2016 Feb
TI  - Regulation of beta-catenin transcription activity by leupaxin in hepatocellular 
      carcinoma.
PG  - 2313-20
LID - 10.1007/s13277-015-4060-4 [doi]
AB  - In human cancers, beta-catenin is accumulated in the nucleus and activates mRNA 
      transcription of many oncogenic genes, such as cyclin D1 and c-myc. However, the 
      mechanism of beta-catenin-mediated transcriptional activation remains largely 
      unknown. In the present study, we identified leupaxin, an adaptor protein sharing 
      homology with the focal adhesion protein, as a novel coactivator for beta-catenin in 
      human hepatocellular carcinoma (HCC). We show that leupaxin could interact with 
      beta-catenin and enhance its transcriptional activity through recruitment of 
      coactivator complex, including steroid receptor coactivator 1 (SRC-1) and P300. 
      As a result, leupaxin regulates HCC cell proliferation and cell-cycle progression 
      in the presence of intact Wnt/beta-catenin signaling. Furthermore, leupaxin is 
      overexpressed in HCC tissues and correlated with mRNA levels of cyclin D1 and 
      c-myc. Therefore, this is the first demonstration of a role for the leupaxin in 
      the regulation of HCC progression, at least in part, by enhancing beta-catenin 
      transcription activity.
FAU - Shi, Jia
AU  - Shi J
AD  - Department of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao 
      Tong University School of Medicine, No. 1665, Kongjiang Road, Shanghai, 200092, 
      China.
FAU - Wu, Wen-Jie
AU  - Wu WJ
AD  - Department of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao 
      Tong University School of Medicine, No. 1665, Kongjiang Road, Shanghai, 200092, 
      China.
FAU - Hu, Gang
AU  - Hu G
AD  - Key Laboratory of Kidney Disease Pathogenesis and Intervention of Hubei Province, 
      College of Medicine, Hubei Polytechnic University, Huangshi, Hubei, 435003, 
      People's Republic of China.
FAU - Yu, Xin
AU  - Yu X
AD  - Key Laboratory of Kidney Disease Pathogenesis and Intervention of Hubei Province, 
      College of Medicine, Hubei Polytechnic University, Huangshi, Hubei, 435003, 
      People's Republic of China.
FAU - Yu, Ge-Shu
AU  - Yu GS
AD  - Key Laboratory of Kidney Disease Pathogenesis and Intervention of Hubei Province, 
      College of Medicine, Hubei Polytechnic University, Huangshi, Hubei, 435003, 
      People's Republic of China.
FAU - Lu, Han
AU  - Lu H
AD  - Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University 
      School of Medicine (SJTU-SM), 197, Rui Jin Er Road, Shanghai, 200025, People's 
      Republic of China.
FAU - Yang, Ming-Liang
AU  - Yang ML
AD  - Department of Anesthesiology, Jianli Second People's Hospital, Jianli, Hubei, 
      433325, People's Republic of China.
FAU - Liu, Bin
AU  - Liu B
AD  - Key Laboratory of Kidney Disease Pathogenesis and Intervention of Hubei Province, 
      College of Medicine, Hubei Polytechnic University, Huangshi, Hubei, 435003, 
      People's Republic of China. liubin3575630@163.com.
FAU - Wu, Zhi-Xiang
AU  - Wu ZX
AD  - Department of Pediatric Surgery, Xin Hua Hospital Affiliated to Shanghai Jiao 
      Tong University School of Medicine, No. 1665, Kongjiang Road, Shanghai, 200092, 
      China. zhixiangwu@yahoo.com.
LA  - eng
PT  - Journal Article
DEP - 20150911
PL  - Netherlands
TA  - Tumour Biol
JT  - Tumour biology : the journal of the International Society for Oncodevelopmental 
      Biology and Medicine
JID - 8409922
RN  - 0 (CTNNB1 protein, human)
RN  - 0 (Cell Adhesion Molecules)
RN  - 0 (LPXN protein, human)
RN  - 0 (Phosphoproteins)
RN  - 0 (beta Catenin)
SB  - IM
MH  - Blotting, Western
MH  - Carcinoma, Hepatocellular/genetics/metabolism/*pathology
MH  - Cell Adhesion Molecules/genetics/*metabolism
MH  - Chromatin Immunoprecipitation
MH  - Gene Expression Regulation, Neoplastic/*genetics
MH  - Gene Knockdown Techniques
MH  - Humans
MH  - Liver Neoplasms/genetics/metabolism/*pathology
MH  - Phosphoproteins/genetics/*metabolism
MH  - Real-Time Polymerase Chain Reaction
MH  - Transcription, Genetic
MH  - beta Catenin/*biosynthesis/genetics
OTO - NOTNLM
OT  - Coactivator
OT  - Hepatocellular carcinoma (HCC)
OT  - Leupaxin
OT  - Transcription activity
OT  - beta-catenin
EDAT- 2015/09/13 06:00
MHDA- 2017/02/01 06:00
CRDT- 2015/09/13 06:00
PHST- 2015/07/09 00:00 [received]
PHST- 2015/09/04 00:00 [accepted]
PHST- 2015/09/13 06:00 [entrez]
PHST- 2015/09/13 06:00 [pubmed]
PHST- 2017/02/01 06:00 [medline]
AID - 10.1007/s13277-015-4060-4 [pii]
AID - 10.1007/s13277-015-4060-4 [doi]
PST - ppublish
SO  - Tumour Biol. 2016 Feb;37(2):2313-20. doi: 10.1007/s13277-015-4060-4. Epub 2015 
      Sep 11.