PMID- 26362795
OWN - NLM
STAT- MEDLINE
DCOM- 20160512
LR  - 20220316
IS  - 1471-230X (Electronic)
IS  - 1471-230X (Linking)
VI  - 15
DP  - 2015 Sep 11
TI  - Effects of acotiamide on esophageal motor function and gastroesophageal reflux in 
      healthy volunteers.
PG  - 117
LID - 10.1186/s12876-015-0346-7 [doi]
LID - 117
AB  - BACKGROUND: The prevalence of gastroesophageal reflux disease (GERD) has been 
      increasing worldwide, with proton pump inhibitor (PPI) administration the current 
      mainstay therapy for affected individuals. However, PPI efficacy is insufficient 
      especially for non-erosive reflux disease. Although it has been reported that 
      prokinetic drugs improve GERD, their effects on esophageal function remain to be 
      clearly investigated. In the present study, we evaluated the direct effects of 
      acotiamide, a novel prokinetic agent for the treatment of functional dyspepsia, 
      on esophageal motor function and gastroesophageal reflux. METHODS: Ten adult 
      healthy volunteers (average age 24 years, range 20-36 years; 7 males, 3 females) 
      were enrolled. Esophageal body peristaltic contractions and lower esophageal 
      sphincter (LES) pressure with and without acotiamide administration were recorded 
      using high resolution manometry using a cross-over protocol. Total and acidic 
      reflux levels for 24 h and during the postprandial period were also recorded 
      using a multichannel intraluminal impedance and pH monitoring system. Data were 
      analyzed blind by one observer. RESULTS: Acotiamide at a standard dose of 300 
      mg/day did not significantly stimulate esophageal motor function. Although the 
      frequency of swallows with weak contraction tended to decrease with acotiamide 
      administration, the difference as compared to no administration was not 
      statistically significant. In addition, the drug neither decreased total or 
      postprandial gastroesophageal acid/non-acid reflux events nor accelerated 
      esophageal clearance time. CONCLUSIONS: Acotiamide, a novel gastrointestinal 
      motility modulator, at a standard dose did not significantly affect esophageal 
      motor functions or gastroesophageal reflux in healthy adults. Additional 
      investigations with GERD patients are necessary to elucidate its clinical 
      significance. TRIAL REGISTRATION: This study was registered on 1st August 2013 
      with the University Hospital Medical Information Network (UMIN) clinical trials 
      registry, as number: UMIN000011260.
FAU - Ishimura, Norihisa
AU  - Ishimura N
AD  - Department of Gastroenterology and Hepatology, Shimane University School of 
      Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan. 
      ishimura@med.shimane-u.ac.jp.
FAU - Mori, Mami
AU  - Mori M
AD  - Department of Gastroenterology and Hepatology, Shimane University School of 
      Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan. 
      mami1117@med.shimane-u.ac.jp.
FAU - Mikami, Hironobu
AU  - Mikami H
AD  - Department of Gastroenterology and Hepatology, Shimane University School of 
      Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan. 
      d_h_m202@med.shimane-u.ac.jp.
FAU - Shimura, Shino
AU  - Shimura S
AD  - Department of Gastroenterology and Hepatology, Shimane University School of 
      Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan. 
      shinoshimura@yahoo.co.jp.
FAU - Uno, Goichi
AU  - Uno G
AD  - Department of Gastroenterology and Hepatology, Shimane University School of 
      Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan. uno511976@yahoo.co.jp.
FAU - Aimi, Masahito
AU  - Aimi M
AD  - Department of Gastroenterology and Hepatology, Shimane University School of 
      Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan. 
      aimi@med.shimane-u.ac.jp.
FAU - Oshima, Naoki
AU  - Oshima N
AD  - Department of Gastroenterology and Hepatology, Shimane University School of 
      Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan. 
      n-oshima@med.shimane-u.ac.jp.
FAU - Ishihara, Shunji
AU  - Ishihara S
AD  - Department of Gastroenterology and Hepatology, Shimane University School of 
      Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan. 
      si360405@med.shimane-u.ac.jp.
FAU - Kinoshita, Yoshikazu
AU  - Kinoshita Y
AD  - Department of Gastroenterology and Hepatology, Shimane University School of 
      Medicine, 89-1, Enya-cho, Izumo, Shimane, 693-8501, Japan. 
      kinosita@med.shimane-u.ac.jp.
LA  - eng
SI  - JPRN/UMIN000011260
PT  - Clinical Study
PT  - Journal Article
DEP - 20150911
PL  - England
TA  - BMC Gastroenterol
JT  - BMC gastroenterology
JID - 100968547
RN  - 0 (Benzamides)
RN  - 0 (Gastrointestinal Agents)
RN  - 0 (Thiazoles)
RN  - D42OWK5383 (Z 338)
SB  - IM
MH  - Adult
MH  - Benzamides/pharmacology/*therapeutic use
MH  - Cross-Over Studies
MH  - Electric Impedance
MH  - Esophageal Sphincter, Lower/*drug effects/physiology
MH  - Esophageal pH Monitoring
MH  - Female
MH  - Gastroesophageal Reflux/*drug therapy
MH  - Gastrointestinal Agents/pharmacology/*therapeutic use
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Manometry
MH  - Peristalsis/*drug effects
MH  - Postprandial Period
MH  - Thiazoles/pharmacology/*therapeutic use
MH  - Young Adult
PMC - PMC4567836
EDAT- 2015/09/13 06:00
MHDA- 2016/05/14 06:00
PMCR- 2015/09/11
CRDT- 2015/09/13 06:00
PHST- 2015/04/13 00:00 [received]
PHST- 2015/09/07 00:00 [accepted]
PHST- 2015/09/13 06:00 [entrez]
PHST- 2015/09/13 06:00 [pubmed]
PHST- 2016/05/14 06:00 [medline]
PHST- 2015/09/11 00:00 [pmc-release]
AID - 10.1186/s12876-015-0346-7 [pii]
AID - 346 [pii]
AID - 10.1186/s12876-015-0346-7 [doi]
PST - epublish
SO  - BMC Gastroenterol. 2015 Sep 11;15:117. doi: 10.1186/s12876-015-0346-7.