PMID- 26363846
OWN - NLM
STAT- MEDLINE
DCOM- 20160914
LR  - 20151128
IS  - 1532-2238 (Electronic)
IS  - 1096-6374 (Linking)
VI  - 25
IP  - 6
DP  - 2015 Dec
TI  - Attaining genetic height potential: Analysis of height outcomes from the ANSWER 
      Program in children treated with growth hormone over 5 years.
PG  - 286-93
LID - S1096-6374(15)30026-5 [pii]
LID - 10.1016/j.ghir.2015.08.006 [doi]
AB  - OBJECTIVE: This study aimed to assess attainment of genetic height potential 
      after long-term growth hormone (GH) treatment in GH-naive children diagnosed with 
      isolated growth hormone deficiency (IGHD), multiple pituitary hormone deficiency 
      (MPHD), born small for gestational age (SGA), or idiopathic short stature (ISS) 
      enrolled in the American Norditropin(R) STUDIES: Web-enabled Research (ANSWER) 
      Program. DESIGN: Children with IGHD (n=2884), MPHD (n=200), SGA (n=481), or ISS 
      (n=733) with baseline height standard deviation score (HSDS)</=-2 were assessed 
      over 5 years of GH treatment for mean HSDS, change in HSDS (DeltaHSDS), and corrected 
      HSDS (HSDS-target HSDS). RESULTS: Mean HSDS and corrected HSDS significantly 
      increased to close to target height across all diagnostic groups after 5 years of 
      GH treatment (P<0.0001). ∆HSDS at year 5 increased for all groups (IGHD: 1.8; 
      MPHD: 2.1; SGA: 1.8; ISS: 1.6). Among patients who continued GH for 5 years, mean 
      insulin-like growth factor-I (IGF-I) SDS increased to within normal range across 
      all groups. Body mass index (BMI) SDS remained relatively stable in all 
      diagnostic groups. Bone age (BA) increased, and the mean BA to chronological age 
      (BA/CA) ratio reached or approached 1 across diagnostic groups over 5 years of GH 
      treatment. CONCLUSIONS: Long-term GH therapy resulted in a significant increase 
      in mean HSDS and corrected HSDS from baseline values in all diagnostic groups. 
      The observed increase in mean corrected HSDS is consistent with growth that 
      approached the patients' genetic height potential, although complete height gains 
      will be evaluated at the attainment of final height.
CI  - Copyright (c) 2015 Elsevier Ltd. All rights reserved.
FAU - Ross, Judith L
AU  - Ross JL
AD  - Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA, United 
      States; Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, United 
      States. Electronic address: judith.ross@jefferson.edu.
FAU - Lee, Peter A
AU  - Lee PA
AD  - Department of Pediatrics, Milton S. Hershey Medical Center, Penn State College of 
      Medicine, Hershey, PA, United States. Electronic address: plee@hmc.psu.edu.
FAU - Gut, Robert
AU  - Gut R
AD  - Novo Nordisk Inc., Plainsboro, NJ, United States. Electronic address: 
      rogu@novonordisk.com.
FAU - Germak, John
AU  - Germak J
AD  - Novo Nordisk Inc., Plainsboro, NJ, United States. Electronic address: 
      jgak@novonordisk.com.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150822
PL  - Scotland
TA  - Growth Horm IGF Res
JT  - Growth hormone & IGF research : official journal of the Growth Hormone Research 
      Society and the International IGF Research Society
JID - 9814320
RN  - 0 (Recombinant Proteins)
RN  - 12629-01-5 (Human Growth Hormone)
SB  - IM
MH  - Adolescent
MH  - *Body Height/genetics
MH  - Child
MH  - Dwarfism, Pituitary/*drug therapy
MH  - Female
MH  - Growth Disorders/*drug therapy
MH  - *Hormone Replacement Therapy
MH  - Human Growth Hormone/deficiency/*therapeutic use
MH  - Humans
MH  - Hypopituitarism/drug therapy
MH  - Infant, Small for Gestational Age
MH  - Male
MH  - Recombinant Proteins/therapeutic use
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Adult height
OT  - Born small for gestational age
OT  - Human growth hormone
OT  - Idiopathic short stature
OT  - Isolated growth hormone deficiency
OT  - Multiple pituitary hormone deficiency
OT  - Short stature
EDAT- 2015/09/14 06:00
MHDA- 2016/09/15 06:00
CRDT- 2015/09/14 06:00
PHST- 2014/08/07 00:00 [received]
PHST- 2015/07/20 00:00 [revised]
PHST- 2015/08/14 00:00 [accepted]
PHST- 2015/09/14 06:00 [entrez]
PHST- 2015/09/14 06:00 [pubmed]
PHST- 2016/09/15 06:00 [medline]
AID - S1096-6374(15)30026-5 [pii]
AID - 10.1016/j.ghir.2015.08.006 [doi]
PST - ppublish
SO  - Growth Horm IGF Res. 2015 Dec;25(6):286-93. doi: 10.1016/j.ghir.2015.08.006. Epub 
      2015 Aug 22.