PMID- 26364227
OWN - NLM
STAT- MEDLINE
DCOM- 20160922
LR  - 20220309
IS  - 1878-0334 (Electronic)
IS  - 1871-4021 (Linking)
VI  - 9
IP  - 4
DP  - 2015 Oct-Dec
TI  - Surprisingly low infertility rate in married type 2 diabetic women: A rather 
      curious paradox to the current opinion of insulin resistance as the joint 
      pathogenesis of poly cystic ovary syndrome and type 2 diabetes mellitus.
PG  - 201-4
LID - S1871-4021(15)00074-0 [pii]
LID - 10.1016/j.dsx.2015.08.007 [doi]
AB  - BACK GROUND: Sharing the same pathophysiologic principle which is insulin 
      resistance, type 2 diabetes mellitus (T2DM) and poly cystic ovary syndrome (PCOS) 
      are usually considered closely related and easily interchangeable medical 
      entities. Numerous attempts have been made to document this illusory perspective. 
      OBJECTIVE: Based on a delicate pathophysiologic notion, we believe that fully 
      developed T2DM is infrequently observed with fully featured PCOS. MATERIALS AND 
      METHODS: In an observational descriptive study 257 married T2DM women were 
      consecutively included and meticulously investigated for fertility history and, 
      albeit, clinical and biochemical features of PCOS. RESULTS: Of 257 married 
      diabetic women only six (2.3%) had no children. In one case a male problem 
      (azoospermia) and in the second case, late marriage (aged 45 at wedding ceremony) 
      was the cause of infertility. Thus, only four (1.6%) might have been labeled as 
      true female factor infertility. Astounding to report was the average pregnancies 
      for each participant which was 5.1+/-2.5, ranging from zero to fifteen. CONCLUSION: 
      we would suggest that, despite the well-established fact of insulin resistance as 
      the common pathophysiologic process for T2DM and PCOS, they are definitely 
      separate medical entities. As a matter of fact T2DM and PCOS are the two opposite 
      aspect of the insulin resistance coin.
CI  - Copyright (c) 2015 Diabetes India. Published by Elsevier Ltd. All rights reserved.
FAU - Tavakolian Arjmand, Abbas
AU  - Tavakolian Arjmand A
AD  - Reproductive Endocrinologist, Department of Internal Medicine, Shahrood Branch, 
      Islamic Azad University, Shahrood, Iran.
FAU - Nouri, Mahnaz
AU  - Nouri M
AD  - Obstetrics and Gynecologist,Department Of Obstetrics & Gynecology, Sharood 
      Branch, Islamic Azad University, Shahrood, Iran. Electronic address: 
      m_nouri@iau-shahrood.ac.ir.
FAU - Tavakolian Arjmand, Shima
AU  - Tavakolian Arjmand S
AD  - Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of 
      Medical Sciences, Sari, Iran.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150822
PL  - Netherlands
TA  - Diabetes Metab Syndr
JT  - Diabetes & metabolic syndrome
JID - 101462250
SB  - IM
MH  - Adult
MH  - Aged
MH  - Diabetes Mellitus, Type 2/*complications/physiopathology
MH  - Female
MH  - Humans
MH  - Infertility/*epidemiology
MH  - *Insulin Resistance
MH  - Iran/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Polycystic Ovary Syndrome/*complications/physiopathology
MH  - Prevalence
OTO - NOTNLM
OT  - Insulin resistance
OT  - Poly cystic ovary syndrome
OT  - Type 2 diabetes mellitus
EDAT- 2015/09/14 06:00
MHDA- 2016/09/23 06:00
CRDT- 2015/09/14 06:00
PHST- 2015/09/14 06:00 [entrez]
PHST- 2015/09/14 06:00 [pubmed]
PHST- 2016/09/23 06:00 [medline]
AID - S1871-4021(15)00074-0 [pii]
AID - 10.1016/j.dsx.2015.08.007 [doi]
PST - ppublish
SO  - Diabetes Metab Syndr. 2015 Oct-Dec;9(4):201-4. doi: 10.1016/j.dsx.2015.08.007. 
      Epub 2015 Aug 22.