PMID- 26365294
OWN - NLM
STAT- MEDLINE
DCOM- 20160617
LR  - 20150923
IS  - 1029-2292 (Electronic)
IS  - 0897-7194 (Linking)
VI  - 33
IP  - 4
DP  - 2015
TI  - Brain-derived neurotrophic factor mediates neuroprotection against Abeta-induced 
      toxicity through a mechanism independent on adenosine 2A receptor activation.
PG  - 298-308
LID - 10.3109/08977194.2015.1080696 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) promotes neuronal survival through 
      TrkB-FL activation. The activation of adenosine A2A receptors (A2AR) is essential 
      for most of BDNF-mediated synaptic actions, such as synaptic plasticity, 
      transmission and neurotransmitter release. We now aimed at evaluating the A2AR 
      influence upon BDNF-mediated neuroprotection against Abeta25-35 toxicity in cultured 
      neurons. Results showed that BDNF increases cell survival and reduces the 
      caspase-3 and calpain activation induced by amyloid-beta (Abeta) peptide, in a 
      mechanism probably dependent on PLCgamma pathway. This BDNF-mediated neuroprotection 
      is not affected by A2AR activation or inhibition. Moreover neither activation nor 
      inhibition of A2AR, per se, significantly influenced Abeta-induced neuronal death on 
      calpain-mediated cleavage of TrkB induced by Abeta. In conclusion, these results 
      suggest that, in opposition to the fast synaptic actions of BDNF, the 
      neuroprotective actions of this neurotrophin against a strong Abeta insult do not 
      require the activation of A2AR.
FAU - Jeronimo-Santos, Andre
AU  - Jeronimo-Santos A
AD  - a Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of 
      Lisbon , Lisbon , Portugal and.
AD  - b Instituto de Medicina Molecular, University of Lisbon , Lisbon , Portugal.
FAU - Fonseca-Gomes, Joao
AU  - Fonseca-Gomes J
AD  - a Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of 
      Lisbon , Lisbon , Portugal and.
AD  - b Instituto de Medicina Molecular, University of Lisbon , Lisbon , Portugal.
FAU - Guimaraes, Diogo Andrade
AU  - Guimaraes DA
AD  - a Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of 
      Lisbon , Lisbon , Portugal and.
AD  - b Instituto de Medicina Molecular, University of Lisbon , Lisbon , Portugal.
FAU - Tanqueiro, Sara Ramalho
AU  - Tanqueiro SR
AD  - a Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of 
      Lisbon , Lisbon , Portugal and.
AD  - b Instituto de Medicina Molecular, University of Lisbon , Lisbon , Portugal.
FAU - Ramalho, Rita Mira
AU  - Ramalho RM
AD  - a Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of 
      Lisbon , Lisbon , Portugal and.
AD  - b Instituto de Medicina Molecular, University of Lisbon , Lisbon , Portugal.
FAU - Ribeiro, Joaquim Alexandre
AU  - Ribeiro JA
AD  - a Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of 
      Lisbon , Lisbon , Portugal and.
AD  - b Instituto de Medicina Molecular, University of Lisbon , Lisbon , Portugal.
FAU - Sebastiao, Ana Maria
AU  - Sebastiao AM
AD  - a Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of 
      Lisbon , Lisbon , Portugal and.
AD  - b Instituto de Medicina Molecular, University of Lisbon , Lisbon , Portugal.
FAU - Diogenes, Maria Jose
AU  - Diogenes MJ
AD  - a Institute of Pharmacology and Neurosciences, Faculty of Medicine, University of 
      Lisbon , Lisbon , Portugal and.
AD  - b Instituto de Medicina Molecular, University of Lisbon , Lisbon , Portugal.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150912
PL  - England
TA  - Growth Factors
JT  - Growth factors (Chur, Switzerland)
JID - 9000468
RN  - 0 (Amyloid beta-Peptides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neuroprotective Agents)
RN  - 0 (Receptors, Adenosine A2)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 3.4.22.- (Caspase 3)
SB  - IM
MH  - Amyloid beta-Peptides/toxicity
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*pharmacology
MH  - Caspase 3/metabolism
MH  - Cells, Cultured
MH  - Neurons/*drug effects/metabolism
MH  - Neuroprotective Agents/*pharmacology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Receptor, trkB/metabolism
MH  - Receptors, Adenosine A2/*metabolism
OTO - NOTNLM
OT  - Adenosine
OT  - BDNF
OT  - TrkB
OT  - amyloid-beta
OT  - calpain
OT  - caspase-3
EDAT- 2015/09/15 06:00
MHDA- 2016/06/18 06:00
CRDT- 2015/09/15 06:00
PHST- 2015/09/15 06:00 [entrez]
PHST- 2015/09/15 06:00 [pubmed]
PHST- 2016/06/18 06:00 [medline]
AID - 10.3109/08977194.2015.1080696 [doi]
PST - ppublish
SO  - Growth Factors. 2015;33(4):298-308. doi: 10.3109/08977194.2015.1080696. Epub 2015 
      Sep 12.