PMID- 26365462
OWN - NLM
STAT- MEDLINE
DCOM- 20160901
LR  - 20151027
IS  - 0722-5091 (Print)
IS  - 0722-5091 (Linking)
VI  - 34
IP  - 6
DP  - 2015 Nov-Dec
TI  - Reduced muscle mitochondrial enzyme activity in MuSK-immunized mice.
PG  - 359-63
LID - 10.5414/NP300875 [doi]
AB  - AIM: Muscle specific kinase (MuSK) antibody-positive myasthenia gravis(MG) 
      patients might present with clinical and electrophysiological signs of muscle 
      atrophy. In this study, we investigated the potential contribution of 
      mitochondrial dysfunction to muscle atrophy induced by MuSK immunity. METHODS: 
      Mitochondrial enzyme expression was investigated in muscle samples of 
      MuSK-immunized, acetylcholine receptor (AChR)-immunized, and complete Freund's 
      adjuvant (CFA)-immunized C57BL/6 (B6) mice using histochemical methods. 
      Mitochondrial enzyme activity was also investigated in MuSK- and CFA-immunized 
      mice. RESULTS: Histochemical analysis showed normal muscle fiber activity on 
      succinate dehydrogenase (SDH) and cytochrome oxidase (COX) stains in all 
      immunization groups. However, MuSK-immunized mice had more ragged-red fibers on 
      modified Gomori-trichrome (MGT) stain and more pronounced type 1 muscle fiber 
      atrophy. MuSK-immunized mice also showed reduced citrate synthase, SDH, and 
      NADH-cytochrome c-reductase activity. DISCUSSION: Our results suggest that 
      MuSK-immunity might induce muscle atrophy through mitochondrial dysfunction.
FAU - Ozkok, Elif
AU  - Ozkok E
FAU - Durmus, Hacer
AU  - Durmus H
FAU - Yetimler, Berrak
AU  - Yetimler B
FAU - Tasli, Hatice
AU  - Tasli H
FAU - Trakas, Nikolaos
AU  - Trakas N
FAU - Ulusoy, Canan
AU  - Ulusoy C
FAU - Lagoumintzis, George
AU  - Lagoumintzis G
FAU - Tzartos, Socrates
AU  - Tzartos S
FAU - Tuzun, Erdem
AU  - Tuzun E
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Neuropathol
JT  - Clinical neuropathology
JID - 8214420
RN  - 0 (Autoantibodies)
RN  - EC 1.3.99.1 (Succinate Dehydrogenase)
RN  - EC 1.9.3.1 (Electron Transport Complex IV)
RN  - EC 2.7.- (Phosphotransferases)
SB  - IM
MH  - Animals
MH  - Autoantibodies/immunology
MH  - Disease Models, Animal
MH  - Electron Transport Complex IV/*metabolism
MH  - Mice, Inbred C57BL
MH  - Mitochondria/*enzymology
MH  - Muscular Diseases/*enzymology
MH  - Myasthenia Gravis/*enzymology
MH  - Phosphotransferases/*immunology
MH  - Succinate Dehydrogenase/*metabolism
EDAT- 2015/09/15 06:00
MHDA- 2016/09/02 06:00
CRDT- 2015/09/15 06:00
PHST- 2015/10/26 00:00 [accepted]
PHST- 2015/09/15 06:00 [entrez]
PHST- 2015/09/15 06:00 [pubmed]
PHST- 2016/09/02 06:00 [medline]
AID - 13716 [pii]
AID - 10.5414/NP300875 [doi]
PST - ppublish
SO  - Clin Neuropathol. 2015 Nov-Dec;34(6):359-63. doi: 10.5414/NP300875.