PMID- 26367070
OWN - NLM
STAT- MEDLINE
DCOM- 20160921
LR  - 20211203
IS  - 1872-6968 (Electronic)
IS  - 0303-8467 (Linking)
VI  - 138
DP  - 2015 Nov
TI  - Presence of the HLADR13 allele among Mexican Mestizos suggests a protective 
      factor against relapsing-remitting multiple sclerosis (RRMS).
PG  - 184-7
LID - S0303-8467(15)00292-9 [pii]
LID - 10.1016/j.clineuro.2015.08.016 [doi]
AB  - BACKGROUND AND OBJECTIVE: Multiple sclerosis (MS) is a chronic demyelinating 
      disease that affects the central nervous system. Researchers have looked for an 
      association between relapsing-remitting MS (RRMS) and human leukocyte antigen 
      (HLA) as risk or protective factor associated to ethnicity, which may add a 
      partial explanation to disease heterogeneity and geographical variations. We 
      described the frequency of the HLA-DR alleles in Mexican Mestizo (RRMS) patients. 
      PATIENTS AND METHODS: We included 143 RRMS patients and 377 healthy controls, 
      both Mexican Mestizos. Previous signing informed consent, we record demographic 
      and clinical characteristics of the participants. Genetic profile was made, and 
      HLA frequencies in both groups were compared. RESULTS: RRMS patients were 39.8% 
      male and 60.2% female, mean age was 35 years. While, controls were 48%male and 
      52% women, mean age was 38 years. The most frequent allele found in subjects with 
      RRMS was DR 15 (p=0.006, OR=2.2, 95% CI: 1.3-3.6). DR 13 allele was more frequent 
      among healthy subjects than RRMS patients (p=0.050) with a protective OR 2.6, 
      (95% CI: 1.3-5.2, p=0.050). CONCLUSION: In our study we found HLA DR 13 was more 
      frequent in healthy controls than in RRMS patients, suggesting a protective 
      factor among Mexican Mestizo population.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Flores, Jose
AU  - Flores J
AD  - Laboratory of Clinical Neurodegenerative Diseases, National Institute of 
      Neurology and Neurosurgery of Mexico, Insurgentes Sur # 3877, CP 14269 Mexico 
      City, Mexico.
FAU - Granados, Julio
AU  - Granados J
AD  - Genetics and Neuroimmunology Laboratory, National Institute of Medical Sciences 
      and Nutrition, Periferico Sur # 4809, CP 14610 Mexico City, Mexico. Electronic 
      address: julgrate@yahoo.com.
FAU - Alonso, E
AU  - Alonso E
AD  - Genetics Laboratory, National Institute of Neurology and Neurosurgery of Mexico, 
      Insurgentes Sur # 3877, CP 14269 Mexico City, Mexico.
FAU - Rito, Yamel
AU  - Rito Y
AD  - Laboratory of Clinical Neurodegenerative Diseases, National Institute of 
      Neurology and Neurosurgery of Mexico, Insurgentes Sur # 3877, CP 14269 Mexico 
      City, Mexico.
FAU - Ortega-Hernandez, Esteban
AU  - Ortega-Hernandez E
AD  - Genetics and Neuroimmunology Laboratory, National Institute of Medical Sciences 
      and Nutrition, Periferico Sur # 4809, CP 14610 Mexico City, Mexico.
FAU - Mena-Hernandez, Lourdes
AU  - Mena-Hernandez L
AD  - Genetics and Neuroimmunology Laboratory, National Institute of Medical Sciences 
      and Nutrition, Periferico Sur # 4809, CP 14610 Mexico City, Mexico.
FAU - Corona, Teresa
AU  - Corona T
AD  - Laboratory of Clinical Neurodegenerative Diseases, National Institute of 
      Neurology and Neurosurgery of Mexico, Insurgentes Sur # 3877, CP 14269 Mexico 
      City, Mexico. Electronic address: coronav@servidorunam.mx.
LA  - eng
PT  - Journal Article
DEP - 20150831
PL  - Netherlands
TA  - Clin Neurol Neurosurg
JT  - Clinical neurology and neurosurgery
JID - 7502039
RN  - 0 (HLA-DR Serological Subtypes)
RN  - 0 (HLA-DR13 antigen)
SB  - IM
MH  - Adult
MH  - Alleles
MH  - Ethnicity/genetics
MH  - Female
MH  - *Genetic Predisposition to Disease
MH  - Genotype
MH  - HLA-DR Serological Subtypes/genetics
MH  - Humans
MH  - Male
MH  - Mexico
MH  - Middle Aged
MH  - Multiple Sclerosis, Relapsing-Remitting/ethnology/*genetics
MH  - *Protective Factors
OTO - NOTNLM
OT  - Alleles
OT  - HLA-DR
OT  - Mexican Mestizos
OT  - Multiple sclerosis relapsing-remitting
OT  - Protective factors
EDAT- 2015/09/15 06:00
MHDA- 2016/09/23 06:00
CRDT- 2015/09/15 06:00
PHST- 2015/02/19 00:00 [received]
PHST- 2015/07/22 00:00 [revised]
PHST- 2015/08/18 00:00 [accepted]
PHST- 2015/09/15 06:00 [entrez]
PHST- 2015/09/15 06:00 [pubmed]
PHST- 2016/09/23 06:00 [medline]
AID - S0303-8467(15)00292-9 [pii]
AID - 10.1016/j.clineuro.2015.08.016 [doi]
PST - ppublish
SO  - Clin Neurol Neurosurg. 2015 Nov;138:184-7. doi: 10.1016/j.clineuro.2015.08.016. 
      Epub 2015 Aug 31.