PMID- 26368803
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 9
DP  - 2015
TI  - Exercise Prevents Memory Impairment Induced by Arsenic Exposure in Mice: 
      Implication of Hippocampal BDNF and CREB.
PG  - e0137810
LID - 10.1371/journal.pone.0137810 [doi]
LID - e0137810
AB  - High concentrations of arsenic, which can be occasionally found in drinking 
      water, have been recognized as a global health problem. Exposure to arsenic can 
      disrupt spatial memory; however, the underlying mechanism remains unclear. In the 
      present study, we tested whether exercise could interfere with the effect of 
      arsenic exposure on the long-term memory (LTM) of object recognition in mice. 
      Arsenic (0, 1, 3, and 10 mg/ kg, i.g.) was administered daily for 12 weeks. We 
      found that arsenic at dosages of 1, 3, and 10 mg/kg decreased body weight and 
      increased the arsenic content in the brain. The object recognition LTM (tested 24 
      h after training) was disrupted by 3 mg/ kg and 10 mg/ kg, but not 1 mg/ kg 
      arsenic exposure. Swimming exercise also prevented LTM impairment induced by 3 
      mg/ kg, but not with 10 mg/ kg, of arsenic exposure. The expression of 
      brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP-response element 
      binding protein (pCREB) in the CA1 and dentate gyrus areas (DG) of the dorsal 
      hippocampus were decreased by 3 mg/ kg and 10 mg/ kg, but not by 1 mg/ kg, of 
      arsenic exposure. The decrease in BDNF and pCREB in the CA1 and DG induced by 3 
      mg/ kg, but not 10 mg/ kg, of arsenic exposure were prevented by swimming 
      exercise. Arsenic exposure did not affect the total CREB expression in the CA1 or 
      DG. Taken together, these results indicated that swimming exercise prevented the 
      impairment of object recognition LTM induced by arsenic exposure, which may be 
      mediated by BDNF and CREB in the dorsal hippocampus.
FAU - Sun, Bao-Fei
AU  - Sun BF
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Wang, Qing-Qing
AU  - Wang QQ
AD  - Department of Hospital Infection Management, Affiliated Hospital of Guiyang 
      Medical University, Guiyang, 550004, China.
FAU - Yu, Zi-Jiang
AU  - Yu ZJ
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Yu, Yan
AU  - Yu Y
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Xiao, Chao-Lun
AU  - Xiao CL
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Kang, Chao-Sheng
AU  - Kang CS
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Ge, Guo
AU  - Ge G
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Linghu, Yan
AU  - Linghu Y
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Zhu, Jun-De
AU  - Zhu JD
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Li, Yu-Mei
AU  - Li YM
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Li, Qiang-Ming
AU  - Li QM
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Luo, Shi-Peng
AU  - Luo SP
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Yang, Dang
AU  - Yang D
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Li, Lin
AU  - Li L
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Zhang, Wen-Yan
AU  - Zhang WY
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
FAU - Tian, Guang
AU  - Tian G
AD  - Department of Anatomy, Guiyang Medical University, Guiyang, 550004, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150914
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 2.3.1.48 (CREB-Binding Protein)
RN  - EC 2.3.1.48 (Crebbp protein, mouse)
RN  - N712M78A8G (Arsenic)
SB  - IM
MH  - Animals
MH  - Arsenic/*adverse effects/pharmacology
MH  - Behavior, Animal
MH  - Brain/drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - CREB-Binding Protein/*metabolism
MH  - Disease Models, Animal
MH  - Gene Expression Regulation/drug effects
MH  - Male
MH  - Memory Disorders/etiology/physiopathology/*prevention & control
MH  - Memory, Long-Term/drug effects
MH  - Mice
MH  - Physical Conditioning, Animal/*methods
MH  - Swimming/physiology
PMC - PMC4569337
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/09/15 06:00
MHDA- 2016/06/09 06:00
PMCR- 2015/09/14
CRDT- 2015/09/15 06:00
PHST- 2015/03/31 00:00 [received]
PHST- 2015/08/20 00:00 [accepted]
PHST- 2015/09/15 06:00 [entrez]
PHST- 2015/09/15 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
PHST- 2015/09/14 00:00 [pmc-release]
AID - PONE-D-15-12085 [pii]
AID - 10.1371/journal.pone.0137810 [doi]
PST - epublish
SO  - PLoS One. 2015 Sep 14;10(9):e0137810. doi: 10.1371/journal.pone.0137810. 
      eCollection 2015.