PMID- 26368940
OWN - NLM
STAT- MEDLINE
DCOM- 20160914
LR  - 20231213
IS  - 1878-4216 (Electronic)
IS  - 0278-5846 (Linking)
VI  - 65
DP  - 2016 Feb 4
TI  - miR-182 (microRNA-182) suppression in the hippocampus evokes antidepressant-like 
      effects in rats.
PG  - 96-103
LID - S0278-5846(15)30040-3 [pii]
LID - 10.1016/j.pnpbp.2015.09.004 [doi]
AB  - Depression is a serious and potentially life-threatening mental disorder with 
      unknown etiology. Emerging evidence shows that brain-derived neurotrophic factor 
      (BDNF) and microRNAs (miRNAs) play critical roles in the etiology of depression. 
      However, the molecular mechanisms are not fully understood. Expression of miR-182 
      and BDNF in the hippocampus were analyzed in a chronic unpredictable mild stress 
      (CUMS) model. Male Wistar rats received bilateral intra-hippocampal infusions of 
      BDNF- and miR-182-expressing (miR-182) or miR-182-silencers (si-miR-182) 
      lentiviral vectors (LV). miR-182 upregulation was correlated with decreased BDNF 
      expression in the hippocampus of a CUMS model. Accordingly, an anti-depressant 
      like effect was observed when LV-BDNF or LV-si-miR-182 was injected into the 
      hippocampus. Moreover, BDNF and its target gene cyclic AMP responsive element 
      binding protein 1 (CREB1) decreased following LV-miR-182 injection and increased 
      upon LV-si-miR-182 injection in rat hippocampus and cultured neuronal cells. In 
      contrast, miR-182 overexpression exacerbated depression-like behaviors and 
      decreased BDNF. Further, luciferase reporter evidence confirmed BDNF was a 
      miR-182 target. Taken together, the current results reveal a potential molecular 
      regulation of miR-182 on BDNF and the pronounced behavioral consequences of this 
      regulation.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Li, Yuefeng
AU  - Li Y
AD  - The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China; 
      Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
FAU - Li, Siyue
AU  - Li S
AD  - Nanjing Medical University, Nanjing, 210029, China.
FAU - Yan, Jinchuan
AU  - Yan J
AD  - The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
FAU - Wang, Dongqing
AU  - Wang D
AD  - The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
FAU - Yin, Ruigen
AU  - Yin R
AD  - The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
FAU - Zhao, Liang
AU  - Zhao L
AD  - The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
FAU - Zhu, Yan
AU  - Zhu Y
AD  - The Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China.
FAU - Zhu, Xiaolan
AU  - Zhu X
AD  - Jiangsu University, Zhenjiang, Jiangsu, 212001, China; The Fourth Affiliated 
      Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212001, China. Electronic 
      address: jiangdalyf2009@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150912
PL  - England
TA  - Prog Neuropsychopharmacol Biol Psychiatry
JT  - Progress in neuro-psychopharmacology & biological psychiatry
JID - 8211617
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Creb1 protein, rat)
RN  - 0 (Cyclic AMP Response Element-Binding Protein)
RN  - 0 (MIRN182 microRNA, rat)
RN  - 0 (MicroRNAs)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/genetics/metabolism
MH  - Chronic Disease
MH  - Cyclic AMP Response Element-Binding Protein/metabolism
MH  - Depressive Disorder/*metabolism/*therapy
MH  - Disease Models, Animal
MH  - Genetic Therapy/*methods
MH  - Genetic Vectors
MH  - Hippocampus/*metabolism
MH  - Lentivirus/genetics
MH  - Male
MH  - MicroRNAs/genetics/*metabolism
MH  - Rats, Wistar
MH  - Stress, Psychological/metabolism/therapy
MH  - Uncertainty
OTO - NOTNLM
OT  - BDNF
OT  - Depression
OT  - Hippocampus
OT  - miR-182
EDAT- 2015/09/15 06:00
MHDA- 2016/09/15 06:00
CRDT- 2015/09/15 06:00
PHST- 2015/08/02 00:00 [received]
PHST- 2015/09/05 00:00 [revised]
PHST- 2015/09/07 00:00 [accepted]
PHST- 2015/09/15 06:00 [entrez]
PHST- 2015/09/15 06:00 [pubmed]
PHST- 2016/09/15 06:00 [medline]
AID - S0278-5846(15)30040-3 [pii]
AID - 10.1016/j.pnpbp.2015.09.004 [doi]
PST - ppublish
SO  - Prog Neuropsychopharmacol Biol Psychiatry. 2016 Feb 4;65:96-103. doi: 
      10.1016/j.pnpbp.2015.09.004. Epub 2015 Sep 12.