PMID- 26370689
OWN - NLM
STAT- MEDLINE
DCOM- 20160923
LR  - 20220408
IS  - 1432-1238 (Electronic)
IS  - 0342-4642 (Linking)
VI  - 42
IP  - 1
DP  - 2016 Jan
TI  - Risk of type 2 diabetes mellitus in patients with acute critical illness: a 
      population-based cohort study.
PG  - 38-45
LID - 10.1007/s00134-015-4044-2 [doi]
AB  - PURPOSE: This large population-based cohort study evaluated the association 
      between certain critical illnesses and the incidence of newly diagnosed type 2 
      diabetes mellitus (T2DM) in Taiwan. METHODS: Data were obtained from the Taiwan 
      National Health Insurance Research Database. According to age, sex, and 
      propensity score-matching, a cohort comprising 9528 patients with critical 
      illness, including septicemia, septic shock, acute myocardial infarction (AMI), 
      and stroke, and a control cohort of 9528 patients with no critical illness were 
      identified. Cox proportional-hazard regression and competing-risk regression 
      models were employed to evaluate the risk of developing T2DM. FINDINGS: With the 
      median follow-up periods (interquartile range) of 3.86 (1.64-6.93) and 5.12 
      (2.51-8.13) years for the patients in the critical illness and control cohorts, 
      respectively, the risk of developing T2DM in the critical illness cohort was 
      significantly higher than in the control cohort (adjusted hazard ratio, aHR = 
      1.32; 95% confidence interval, CI 1.16-1.50). In the multivariate competing-risk 
      regression models, the aHR of T2DM was 1.58 (95% CI 1.45-1.72) in the critical 
      illness cohort. Moreover, among the patients with these critical illnesses, those 
      with septicemia or septic shock exhibited the highest risk of developing T2DM 
      (aHR = 1.51, 95% CI 1.37-1.67), followed by AMI compared with the control cohort. 
      CONCLUSION: Our results suggest that patients with certain critical illnesses are 
      associated with a high risk of developing T2DM. Clinicians should be aware of 
      this association and intensively screen for T2DM in patients following diagnosis 
      of critical illness.
FAU - Hsu, Chin-Wang
AU  - Hsu CW
AD  - Department of Emergency Medicine, School of Medicine, College of Medicine, Taipei 
      Medical University, Taipei, Taiwan.
AD  - Department of Emergency and Critical Medicine, Wan Fang Hospital, Taipei Medical 
      University, Taipei, Taiwan.
FAU - Lin, Chin-Sheng
AU  - Lin CS
AD  - Division of Cardiology, Department of Medicine, Tri-Service General Hospital, 
      National Defense Medical Center, Taipei, Taiwan.
FAU - Chen, Sy-Jou
AU  - Chen SJ
AD  - Department of Emergency Medicine, Tri-Service General Hospital, National Defense 
      Medical Center, Taipei, Taiwan.
FAU - Lin, Shih-Hua
AU  - Lin SH
AD  - Division of Nephrology, Department of Medicine, Tri-Service General Hospital, 
      National Defense Medical Center, Taipei, Taiwan.
FAU - Lin, Cheng-Li
AU  - Lin CL
AD  - Management Office for Health Data, China Medical University Hospital, Taichung, 
      Taiwan.
AD  - College of Medicine, China Medical University, Taichung, Taiwan.
FAU - Kao, Chia-Hung
AU  - Kao CH
AD  - Graduate Institute of Clinical Medical Science and School of Medicine, College of 
      Medicine, China Medical University, Taichung, Taiwan. d10040@mail.cmuh.org.tw.
AD  - Department of Nuclear Medicine and PET Center, China Medical University Hospital, 
      Taichung, Taiwan. d10040@mail.cmuh.org.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150914
PL  - United States
TA  - Intensive Care Med
JT  - Intensive care medicine
JID - 7704851
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Critical Illness
MH  - Diabetes Mellitus, Type 2/*epidemiology/etiology
MH  - Female
MH  - Humans
MH  - Hyperglycemia/complications/etiology/physiopathology
MH  - Incidence
MH  - Insurance Claim Review/statistics & numerical data
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - Myocardial Infarction/complications/physiopathology
MH  - Population Surveillance/methods
MH  - Propensity Score
MH  - Proportional Hazards Models
MH  - Retrospective Studies
MH  - Risk Assessment/methods
MH  - Sepsis/complications/physiopathology
MH  - Stress, Physiological/physiology
MH  - Stroke/complications/physiopathology
MH  - Taiwan/epidemiology
OTO - NOTNLM
OT  - Acute myocardial infarction
OT  - Critical illness
OT  - Sepsis
OT  - Stroke
OT  - Taiwan National Health Insurance Research Database
OT  - Type 2 diabetes
EDAT- 2015/09/16 06:00
MHDA- 2016/09/24 06:00
CRDT- 2015/09/16 06:00
PHST- 2015/07/05 00:00 [received]
PHST- 2015/08/26 00:00 [accepted]
PHST- 2015/09/16 06:00 [entrez]
PHST- 2015/09/16 06:00 [pubmed]
PHST- 2016/09/24 06:00 [medline]
AID - 10.1007/s00134-015-4044-2 [pii]
AID - 10.1007/s00134-015-4044-2 [doi]
PST - ppublish
SO  - Intensive Care Med. 2016 Jan;42(1):38-45. doi: 10.1007/s00134-015-4044-2. Epub 
      2015 Sep 14.