PMID- 26372271
OWN - NLM
STAT- MEDLINE
DCOM- 20160606
LR  - 20221207
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Linking)
VI  - 29
IP  - 13
DP  - 2015 Aug 24
TI  - The effect of KIR2D-HLA-C receptor-ligand interactions on clinical outcome in a 
      HIV-1 CRF01_AE-infected Thai population.
PG  - 1607-15
LID - 10.1097/QAD.0000000000000747 [doi]
AB  - OBJECTIVE: Class I human leukocyte antigen (HLA) alleles interact with both 
      cytotoxic T lymphocytes through their T-cell receptors, and natural killer cells 
      through their killer immunoglobulin-like receptors (KIRs). Compared with the 
      reported protective effect of KIR3DL1/S1-HLA-Bw4 interactions in HIV-infected 
      patients, the effect of KIR2D-HLA-C combinations on HIV control remains unclear. 
      Here, we investigate the effect of KIR2D-HLA-C combinations on HIV disease 
      progression. DESIGN: We performed a cross-sectional and longitudinal analysis of 
      a Thai HIV cohort. METHODS: Two hundred and nine HIV-1 CRF01_AE-infected, 
      treatment-naive Thai patients (CD4 T-cell counts of >200/mul) and 104 exposed 
      seronegatives were studied. The effect of KIR-HLA receptor-ligand combinations on 
      viral transmission and survival rate was statistically analyzed. RESULTS: We 
      found the following results: higher frequency of patients expressing both KIR2DL3 
      and HLA-C1 among infected patients compared with exposed seronegative (odds ratio 
      4.8, P = 0.004), higher viral load in patients expressing HLA-C1 with KIR2DL3 
      compared with those without this receptor-ligand combination (median 4.8 vs. 
      4.2 log copies/ml, P = 0.033), higher numbers of KIR2DL3-HLA-C1 interactions was 
      associated with a higher viral load (beta = 0.13, P = 0.039 by linear regression 
      model), and higher mortality rate in carriers of the KIR2DL3-HLA-C1 combination 
      (adjusted hazard ratio 1.9, P = 0.012 by Cox hazard model). CONCLUSION: We have 
      identified a deleterious effect of the KIR2DL3-HLA-C1 receptor-ligand combination 
      on HIV clinical outcomes in a Thai cohort. Further investigation into mechanisms 
      underlying this susceptibility may aid the understanding of the role of natural 
      killer cells in HIV disease control and pathogenesis.
FAU - Mori, Masahiko
AU  - Mori M
AD  - aDepartment of Clinical Medicine, Institute of Tropical Medicine, Nagasaki 
      University, Nagasaki, Japan bDepartment of Paediatrics, University of Oxford, 
      Oxford, UK cThai National Institute of Health, Department of Medical Sciences, 
      Ministry of Public Health, Nonthaburi dDay Care Centre, Lampang Hospital, 
      Lampang, Thailand eNagasaki University Global COE Program, Institute of Tropical 
      Medicine, Nagasaki University, Nagasaki, Japan.
FAU - Wichukchinda, Nuanjun
AU  - Wichukchinda N
FAU - Miyahara, Reiko
AU  - Miyahara R
FAU - Rojanawiwat, Archawin
AU  - Rojanawiwat A
FAU - Pathipvanich, Panita
AU  - Pathipvanich P
FAU - Tsuchiya, Naho
AU  - Tsuchiya N
FAU - Miura, Toshiyuki
AU  - Miura T
FAU - Yasunami, Michio
AU  - Yasunami M
FAU - Ariyoshi, Koya
AU  - Ariyoshi K
FAU - Sawanpanyalert, Pathom
AU  - Sawanpanyalert P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (HLA-C Antigens)
RN  - 0 (KIR2DL3 protein, human)
RN  - 0 (Receptors, KIR2DL3)
SB  - IM
MH  - Adult
MH  - Asian People
MH  - Cross-Sectional Studies
MH  - Disease Progression
MH  - *Disease Susceptibility
MH  - Female
MH  - HIV Infections/*immunology/transmission/virology
MH  - HIV-1/*immunology
MH  - HLA-C Antigens/*metabolism
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Receptors, KIR2DL3/*metabolism
MH  - Survival Analysis
MH  - Treatment Outcome
EDAT- 2015/09/16 06:00
MHDA- 2016/06/09 06:00
CRDT- 2015/09/16 06:00
PHST- 2015/09/16 06:00 [entrez]
PHST- 2015/09/16 06:00 [pubmed]
PHST- 2016/06/09 06:00 [medline]
AID - 00002030-201508240-00004 [pii]
AID - 10.1097/QAD.0000000000000747 [doi]
PST - ppublish
SO  - AIDS. 2015 Aug 24;29(13):1607-15. doi: 10.1097/QAD.0000000000000747.