PMID- 26372899
OWN - NLM
STAT- MEDLINE
DCOM- 20160709
LR  - 20181202
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 47
IP  - 11
DP  - 2015 Oct
TI  - Association between Serum Total Osteocalcin Level and Type 2 Diabetes Mellitus: A 
      Systematic Review and Meta-Analysis.
PG  - 813-9
LID - 10.1055/s-0035-1564134 [doi]
AB  - Studies on the association between serum total osteocalcin level and type 2 
      diabetes mellitus (T2DM) had reported controversial results. The aim of this 
      study was to comprehensively assess this association through a meta-analysis. 
      Eligible articles were identified in electronic databases from their inception 
      through May 1, 2015. To assess the relationship between serum total osteocalcin 
      and T2DM, a meta-analysis was performed to determine whether total osteocalcin 
      differed obviously between individuals with and without T2DM, and whether serum 
      total osteocalcin level was associated with the risk of T2DM. The standardized 
      mean difference (SMD) and their 95% confidence intervals (95% CIs) for total 
      osteocalcin between individuals with and without T2DM, and pooled odds ratios 
      (ORs) and their 95% CI for the T2DM risk were calculated by meta-analysis. 
      Twenty-four papers fulfilled the inclusion criteria. From the pooled data, the 
      total osteocalcin level was significantly lower among T2DM patients than controls 
      (SMD: - 2.87; 95% CI-3.76 to - 1.98; p<0.00001), and high total osteocalcin level 
      was significantly and independently associated with decreased risk of T2DM 
      (OR=0.70, 95% CI 0.56-0.88; p=0.002). There was no evidence for publication bias. 
      Serum total osteocalcin level is significantly lower in T2DM patients than 
      controls, and total osteocalcin is inversely associated with the development of 
      T2DM.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Liu, C
AU  - Liu C
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Wo, J
AU  - Wo J
AD  - Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Zhao, Q
AU  - Zhao Q
AD  - Department of Cardiology, The Affiliated Hospital of Qingdao University, Qingdao, 
      China.
FAU - Wang, Y
AU  - Wang Y
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Wang, B
AU  - Wang B
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
FAU - Zhao, W
AU  - Zhao W
AD  - Department of Endocrinology, The Affiliated Hospital of Qingdao University, 
      Qingdao, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20150915
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 104982-03-8 (Osteocalcin)
SB  - IM
MH  - Aged
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Osteocalcin/*blood
MH  - Publication Bias
EDAT- 2015/09/16 06:00
MHDA- 2016/07/10 06:00
CRDT- 2015/09/16 06:00
PHST- 2015/09/16 06:00 [entrez]
PHST- 2015/09/16 06:00 [pubmed]
PHST- 2016/07/10 06:00 [medline]
AID - 10.1055/s-0035-1564134 [doi]
PST - ppublish
SO  - Horm Metab Res. 2015 Oct;47(11):813-9. doi: 10.1055/s-0035-1564134. Epub 2015 Sep 
      15.