PMID- 26373475
OWN - NLM
STAT- MEDLINE
DCOM- 20160801
LR  - 20151015
IS  - 1399-0039 (Electronic)
IS  - 0001-2815 (Linking)
VI  - 86
IP  - 5
DP  - 2015 Nov
TI  - Antibody-reactive class I epitopes defined by pairs of mismatched eplets and 
      self-eplets.
PG  - 368-72
LID - 10.1111/tan.12652 [doi]
AB  - The identification of human leukocyte antigen (HLA) antibodies in the sera of 
      candidates awaiting organ transplantation has evolved over time. This has been 
      possible because of the introduction of more sensitive techniques and to the 
      increasing focus on the structural aspects of the HLA epitopes. The use of the 
      HLAMatchmaker algorithm in the analysis of positive sera and the verification of 
      HLA ABC epitopes in the HLA Epitope Registry website provide new stimuli on the 
      interpretation of antibody reactivity. The epitopes defined by eplet pairs often 
      involve a nonself-eplet and a self-eplet (nonself-self paradigm), suggesting that 
      the antibody response to an HLA mismatch must have an auto-reactive component. 
      Here, we report an application of the nonself-self paradigm that provides a basis 
      for better knowledge and interpretation of HLA-antibody reactivity in Luminex 
      assays with single alleles.
CI  - (c) 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Resse, M
AU  - Resse M
AD  - U.O.C. Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), 
      Regional Reference Laboratory of Transplant Immunology (LIT), Azienda Ospedaliera 
      Universitaria (AOU), Second University of Naples, Naples, Italy.
FAU - Paolillo, R
AU  - Paolillo R
AD  - U.O.C. Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), 
      Regional Reference Laboratory of Transplant Immunology (LIT), Azienda Ospedaliera 
      Universitaria (AOU), Second University of Naples, Naples, Italy.
FAU - Minucci, B P
AU  - Minucci BP
AD  - U.O.C. Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), 
      Regional Reference Laboratory of Transplant Immunology (LIT), Azienda Ospedaliera 
      Universitaria (AOU), Second University of Naples, Naples, Italy.
FAU - Moccia, G
AU  - Moccia G
AD  - U.O.C. Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), 
      Regional Reference Laboratory of Transplant Immunology (LIT), Azienda Ospedaliera 
      Universitaria (AOU), Second University of Naples, Naples, Italy.
FAU - Napoli, C
AU  - Napoli C
AD  - U.O.C. Immunohematology, Transfusion Medicine and Transplant Immunology (SIMT), 
      Regional Reference Laboratory of Transplant Immunology (LIT), Azienda Ospedaliera 
      Universitaria (AOU), Second University of Naples, Naples, Italy.
AD  - Department of Medical, Surgical, Neurological, Metabolic and Geriatric Sciences, 
      Second University of Naples, Naples, Italy.
LA  - eng
PT  - Journal Article
DEP - 20150916
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (Antibodies)
RN  - 0 (Epitopes)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - *Algorithms
MH  - Antibodies/*chemistry/genetics
MH  - Epitopes/*chemistry/genetics
MH  - HLA Antigens/*chemistry/genetics
MH  - Humans
OTO - NOTNLM
OT  - HLAMatchmaker
OT  - eplet pairs
OT  - human leukocyte antigen antibodies
OT  - nonself-self paradigm
EDAT- 2015/09/17 06:00
MHDA- 2016/08/02 06:00
CRDT- 2015/09/17 06:00
PHST- 2015/01/16 00:00 [received]
PHST- 2015/08/05 00:00 [revised]
PHST- 2015/08/17 00:00 [accepted]
PHST- 2015/09/17 06:00 [entrez]
PHST- 2015/09/17 06:00 [pubmed]
PHST- 2016/08/02 06:00 [medline]
AID - 10.1111/tan.12652 [doi]
PST - ppublish
SO  - Tissue Antigens. 2015 Nov;86(5):368-72. doi: 10.1111/tan.12652. Epub 2015 Sep 16.