PMID- 26375584
OWN - NLM
STAT- MEDLINE
DCOM- 20160203
LR  - 20221007
IS  - 1520-4804 (Electronic)
IS  - 0022-2623 (Linking)
VI  - 58
IP  - 20
DP  - 2015 Oct 22
TI  - Discovery of the First Selective, Nonpeptidic Orexin 2 Receptor Agonists.
PG  - 7928-30
LID - 10.1021/acs.jmedchem.5b01394 [doi]
AB  - In this issue, Nagase and colleagues report the discovery of the first selective 
      nonpeptidic orexin 2 receptor (OX2R) agonists. The discovery of these OX2R 
      selective agonists opens up new avenues for therapies related to the activation 
      of the orexin system, especially with respect to the treatment of sleep disorders 
      such as narcolepsy.
FAU - Heifetz, Alexander
AU  - Heifetz A
AD  - Evotec (UK) Ltd. , 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 
      4RZ, United Kingdom.
FAU - Bodkin, Mike J
AU  - Bodkin MJ
AD  - Evotec (UK) Ltd. , 114 Innovation Drive, Milton Park, Abingdon, Oxfordshire OX14 
      4RZ, United Kingdom.
FAU - Biggin, Philip C
AU  - Biggin PC
AD  - Department of Biochemistry, University of Oxford , South Parks Road, Oxford OX1 
      3QU, United Kingdom.
LA  - eng
GR  - BB/L026287/1/BB_/Biotechnology and Biological Sciences Research Council/United 
      Kingdom
PT  - Comment
PT  - Journal Article
DEP - 20150916
PL  - United States
TA  - J Med Chem
JT  - Journal of medicinal chemistry
JID - 9716531
RN  - 0 (Benzamides)
RN  - 0 (Orexin Receptors)
RN  - 0 (Sulfonamides)
SB  - IM
CON - J Med Chem. 2015 Oct 22;58(20):7931-7. PMID: 26267383
MH  - Animals
MH  - Benzamides/*chemical synthesis/*pharmacology
MH  - Humans
MH  - Orexin Receptors/*agonists
MH  - Sulfonamides/*chemical synthesis/*pharmacology
EDAT- 2015/09/17 06:00
MHDA- 2016/02/04 06:00
CRDT- 2015/09/17 06:00
PHST- 2015/09/17 06:00 [entrez]
PHST- 2015/09/17 06:00 [pubmed]
PHST- 2016/02/04 06:00 [medline]
AID - 10.1021/acs.jmedchem.5b01394 [doi]
PST - ppublish
SO  - J Med Chem. 2015 Oct 22;58(20):7928-30. doi: 10.1021/acs.jmedchem.5b01394. Epub 
      2015 Sep 16.