PMID- 26375919
OWN - NLM
STAT- MEDLINE
DCOM- 20160519
LR  - 20220318
IS  - 1809-452X (Electronic)
IS  - 1516-4446 (Linking)
VI  - 37
IP  - 4
DP  - 2015 Oct-Dec
TI  - A 20-week program of resistance or concurrent exercise improves symptoms of 
      schizophrenia: results of a blind, randomized controlled trial.
PG  - 271-9
LID - S1516-44462015005041595 [pii]
LID - 10.1590/1516-4446-2014-1595 [doi]
AB  - OBJECTIVE: To evaluate the effects of 20 weeks of resistance and concurrent 
      training on psychotic and depressive symptoms, quality of life outcomes, and 
      serum IGF-1, IGFBP-3, and brain-derived neurotrophic factor (BDNF) concentrations 
      in patients with schizophrenia. METHODS: In this blind, randomized controlled 
      clinical trial, 34 patients with schizophrenia were assigned to one of three 
      groups: control (CTRL, n=13), resistance exercise (RESEX, n=12), or concurrent 
      exercise (CONCEX, n=9). Symptoms, quality of life, strength, and other variables 
      were assessed. RESULTS: A significant time-by-group interaction was found for the 
      RESEX and CONCEX groups on the Positive and Negative Syndrome Scale (PANSS) total 
      score for disease symptoms (p = 0.007), positive symptoms (p = 0.003), and on the 
      arm extension one-repetition maximum (1RM) test (p = 0.016). In addition, 
      significant improvements on negative symptoms (p = 0.027), on the role-physical 
      domain of the Short Form-36 Health Survey (p = 0.019), and on the chest press 1RM 
      test (p = 0.040) were observed in the RESEX group. No changes were observed for 
      the other variables investigated. CONCLUSIONS: In this sample of patients with 
      schizophrenia, 20 weeks of resistance or concurrent exercise program improved 
      disease symptoms, strength, and quality of life. ClinicalTrials.gov: NCT01674543.
FAU - Silva, Bruna Andrade E
AU  - Silva BA
AD  - Department of Nutrition, Universidade Federal de Sao Paulo (UNIFESP), Sao Paulo, 
      SP, Brazil.
FAU - Cassilhas, Ricardo C
AU  - Cassilhas RC
AD  - Department of Physical Education, Universidade Federal dos Vales do Jequitinhonha 
      e Mucuri, Diamantina, MG, Brazil.
FAU - Attux, Cecilia
AU  - Attux C
AD  - Department of Psychiatry, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Cordeiro, Quirino
AU  - Cordeiro Q
AD  - Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, Sao Paulo, SP, Brazil.
FAU - Gadelha, Andre L
AU  - Gadelha AL
AD  - Department of Psychiatry, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Telles, Bruno A
AU  - Telles BA
AD  - Department of Psychiatry, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Bressan, Rodrigo A
AU  - Bressan RA
AD  - Department of Psychiatry, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Ferreira, Francine N
AU  - Ferreira FN
AD  - Department of Psychiatry, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Rodstein, Paulo H
AU  - Rodstein PH
AD  - Department of Psychiatry, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Daltio, Claudiane S
AU  - Daltio CS
AD  - Department of Psychiatry, UNIFESP, Sao Paulo, SP, Brazil.
FAU - Tufik, Sergio
AU  - Tufik S
AD  - Department of Psychobiology, UNIFESP, Sao Paulo, SP, Brazil.
FAU - de Mello, Marco T
AU  - de Mello MT
AD  - Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.
LA  - eng
SI  - ClinicalTrials.gov/NCT01674543
PT  - Journal Article
PT  - Multicenter Study
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150915
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
RN  - 0 (Antipsychotic Agents)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Analysis of Variance
MH  - Antipsychotic Agents/therapeutic use
MH  - Brain-Derived Neurotrophic Factor/blood
MH  - Exercise Therapy/*methods
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor I/analysis
MH  - Male
MH  - Middle Aged
MH  - Muscle Strength/physiology
MH  - Quality of Life
MH  - Resistance Training/*methods
MH  - Schizophrenia/physiopathology/*rehabilitation
MH  - Single-Blind Method
MH  - Time Factors
MH  - Treatment Outcome
MH  - Young Adult
EDAT- 2015/09/17 06:00
MHDA- 2016/05/20 06:00
CRDT- 2015/09/17 06:00
PHST- 2014/10/23 00:00 [received]
PHST- 2015/02/10 00:00 [accepted]
PHST- 2015/09/17 06:00 [entrez]
PHST- 2015/09/17 06:00 [pubmed]
PHST- 2016/05/20 06:00 [medline]
AID - S1516-44462015005041595 [pii]
AID - 10.1590/1516-4446-2014-1595 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2015 Oct-Dec;37(4):271-9. doi: 10.1590/1516-4446-2014-1595. 
      Epub 2015 Sep 15.