PMID- 26376051
OWN - NLM
STAT- MEDLINE
DCOM- 20160308
LR  - 20181218
IS  - 1809-452X (Electronic)
IS  - 1516-4446 (Linking)
VI  - 37
IP  - 3
DP  - 2015 Jul-Sep
TI  - Association of serum brain-derived neurotrophic factor (BDNF) and tumor necrosis 
      factor-alpha (TNF-alpha) with diagnosis of delirium in oncology inpatients.
PG  - 197-202
LID - S1516-44462015000300003 [pii]
LID - 10.1590/1516-4446-2014-1450 [doi]
AB  - OBJECTIVE: To evaluate brain-derived neurotrophic factor (BDNF) and tumor 
      necrosis factor-alpha (TNF-alpha) blood levels as disease biomarkers of delirium in 
      oncology inpatients. METHODS: Seventeen oncology inpatients with delirium, 28 
      oncology inpatients without delirium, and 25 non-oncology controls (caregivers) 
      were consecutively recruited from a Brazilian cancer center. This sample was 
      matched by age, sex, and education level. The Confusion Assessment Method, the 
      Mini-Mental State Examination, and the Digit Span Test were administered to 
      ascertain delirium diagnosis. BDNF and TNF-alpha levels were measured by the 
      Sandwich-ELISA method and flow cytometry, respectively. Blood samples were 
      collected immediately after clinical evaluation. RESULTS: Oncology inpatients 
      (with and without delirium) showed significantly lower BDNF levels compared with 
      non-oncology controls (F = 13.830; p = 0.001). TNF-alpha levels did not differ 
      between the three groups. CONCLUSION: A cross-sectional relationship of BDNF and 
      TNF-alpha blood levels with delirium in oncology inpatients was not demonstrated. The 
      association between cancer and reduced serum BDNF levels may be mediated by 
      confounding factors.
FAU - Brum, Cristiano
AU  - Brum C
AD  - Graduate Program in Health Sciences, Universidade Federal de Ciencias da Saude de 
      Porto Alegre, Porto Alegre, RS, BR.
FAU - Stertz, Laura
AU  - Stertz L
AD  - Molecular Psychiatry Laboratory, National Science and Technology Institute for 
      Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade 
      Federal do Rio Grande do Sul, Porto Alegre, RS, BR.
FAU - Borba, Ericksen
AU  - Borba E
AD  - Graduate Program in Medical Sciences, UFRGS, Porto Alegre, RS, BR.
FAU - Rumi, Danielle
AU  - Rumi D
AD  - School of Medicine, UFCSPA, Porto Alegre, RS, BR.
FAU - Kapczinski, Flavio
AU  - Kapczinski F
AD  - Molecular Psychiatry Laboratory, National Science and Technology Institute for 
      Translational Medicine, Hospital de Clinicas de Porto Alegre, Universidade 
      Federal do Rio Grande do Sul, Porto Alegre, RS, BR.
FAU - Camozzato, Analuiza
AU  - Camozzato A
AD  - Graduate Program in Health Sciences, Universidade Federal de Ciencias da Saude de 
      Porto Alegre, Porto Alegre, RS, BR.
LA  - eng
PT  - Journal Article
PL  - Brazil
TA  - Braz J Psychiatry
JT  - Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
JID - 100895975
RN  - 0 (Biomarkers)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Biomarkers/blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Case-Control Studies
MH  - Delirium/blood/*diagnosis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Flow Cytometry
MH  - Humans
MH  - Inpatients/*psychology
MH  - Male
MH  - Middle Aged
MH  - Neoplasms/*blood
MH  - Psychiatric Status Rating Scales
MH  - Statistics, Nonparametric
MH  - Tumor Necrosis Factor-alpha/*blood
EDAT- 2015/09/17 06:00
MHDA- 2016/03/10 06:00
CRDT- 2015/09/17 06:00
PHST- 2015/09/17 06:00 [entrez]
PHST- 2015/09/17 06:00 [pubmed]
PHST- 2016/03/10 06:00 [medline]
AID - S1516-44462015000300003 [pii]
AID - 10.1590/1516-4446-2014-1450 [doi]
PST - ppublish
SO  - Braz J Psychiatry. 2015 Jul-Sep;37(3):197-202. doi: 10.1590/1516-4446-2014-1450.