PMID- 26376814
OWN - NLM
STAT- MEDLINE
DCOM- 20170118
LR  - 20181113
IS  - 1308-5263 (Electronic)
IS  - 1300-7777 (Print)
IS  - 1300-7777 (Linking)
VI  - 32
IP  - 4
DP  - 2015 Dec
TI  - The -137G/C Polymorphism in Interleukin-18 Gene Promoter Contributes to Chronic 
      Lymphocytic and Chronic Myelogenous Leukemia Risk in Turkish Patients.
PG  - 311-6
LID - 10.4274/tjh.2014.0126 [doi]
AB  - OBJECTIVE: Interleukin-18 (IL-18) is a cytokine that belongs to the IL-1 
      superfamily and is secreted by various immune and nonimmune cells. Evidence has 
      shown that IL-18 has both anticancer and procancer effects. The aim of this study 
      was to evaluate the relationship between IL-18 gene polymorphisms and 
      susceptibility to chronic lymphocytic leukemias (CLL) and chronic myelogenous 
      leukemias (CML) in Turkish patients. MATERIALS AND METHODS: The frequencies of 
      polymorphisms (rs61667799(G/T), rs5744227(C/G), rs5744228(A/G), and 
      rs187238(G/C)) were studied in 20 CLL patients, 30 CML patients, and 30 healthy 
      individuals. The genotyping was performed by polymerase chain reaction and DNA 
      sequencing analysis. RESULTS: Significant associations were detected between the 
      IL-18 rs187238(G/C) polymorphism and chronic leukemia. A higher prevalence of the 
      C allele was found in CML cases with respect to controls. The GC heterozygous and 
      CC homozygous genotypes were associated with risk of CML when compared with 
      controls. However, prevalence of the C allele was not significantly high in CLL 
      cases with respect to controls. There was only a significant difference between 
      the homozygous CC genotype of CLL patients and the control group; thus, it can be 
      concluded that the CC genotype may be associated with the risk of CLL. Based on 
      our data, there were no significant associations between the IL-18 
      rs61667799(G/T), rs5744227(C/G), or rs5744228(A/G) polymorphisms and CLL or CML. 
      CONCLUSIONS: IL-18 gene promoter rs187238(G/C) polymorphism is associated with 
      chronic leukemia in the Turkish population. However, due to the limited number of 
      studied patients, these are preliminary results that show the association between 
      -137G/C polymorphism and patients (CLL and CML). Further large-scale studies 
      combined with haplotype and expression analysis are required to validate the 
      current findings.
FAU - Yalcin, Serap
AU  - Yalcin S
AD  - Ahi Evran University Faculty of Engineering and Architecture, Kirsehir, Turkey 
      Phone: +90 386 280 38 08 E-mail: syalcin@ahievran.edu.tr.
FAU - Mutlu, Pelin
AU  - Mutlu P
FAU - Cetin, Turker
AU  - Cetin T
FAU - Sarper, Meral
AU  - Sarper M
FAU - Ozgur, Gokhan
AU  - Ozgur G
FAU - Avcu, Ferit
AU  - Avcu F
LA  - eng
PT  - Comparative Study
PT  - Journal Article
DEP - 20140521
PL  - Turkey
TA  - Turk J Haematol
JT  - Turkish journal of haematology : official journal of Turkish Society of 
      Haematology
JID - 9606065
RN  - 0 (Interleukin-18)
SB  - IM
MH  - Alleles
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - Humans
MH  - Interleukin-18/*genetics
MH  - Leukemia, Lymphocytic, Chronic, B-Cell/ethnology/*genetics
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/ethnology/*genetics
MH  - *Polymorphism, Single Nucleotide
MH  - Promoter Regions, Genetic/*genetics
MH  - Risk
MH  - Turkey/epidemiology
PMC - PMC4805319
COIS- Conflict of Interest Statement The authors of this paper have no conflicts of 
      interest, including specific financial interests, relationships, and/or 
      affiliations relevant to the subject matter or materials included.
EDAT- 2014/05/21 00:00
MHDA- 2017/01/19 06:00
PMCR- 2015/12/01
CRDT- 2015/09/18 06:00
PHST- 2015/09/18 06:00 [entrez]
PHST- 2014/05/21 00:00 [pubmed]
PHST- 2017/01/19 06:00 [medline]
PHST- 2015/12/01 00:00 [pmc-release]
AID - 1564 [pii]
AID - 10.4274/tjh.2014.0126 [doi]
PST - ppublish
SO  - Turk J Haematol. 2015 Dec;32(4):311-6. doi: 10.4274/tjh.2014.0126. Epub 2014 May 
      21.