PMID- 26377225 OWN - NLM STAT- MEDLINE DCOM- 20161108 LR - 20221207 IS - 1520-7560 (Electronic) IS - 1520-7552 (Linking) VI - 32 IP - 2 DP - 2016 Feb TI - Positive correlation of plasma PCSK9 levels with HbA1c in patients with type 2 diabetes. PG - 193-9 LID - 10.1002/dmrr.2712 [doi] AB - BACKGROUND: Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been demonstrated to be involved in not only lipid metabolism but also glucose homeostasis. Glycated haemoglobin (HbA1c ) is a 'gold standard' for monitoring long-term glycaemic control. However, the correlation of plasma PCSK9 levels with HbA1c remains undetermined. METHODS: We consecutively enrolled 805 subjects undergoing coronary angiography, including 176 patients with type 2 diabetes mellitus (T2DM) and 629 non-diabetic patients. The baseline characteristics were collected, and serum PCSK9 level was assessed by ELISA. Univariable regression analysis and multiple-variable regression analysis were used to examine the associations of PCSK9 with HbA1c . Furthermore, the HbA1c was compared across the tertiles of PCSK9 levels. And also, PCSK9 levels were compared in poorly controlled (HbA1c >/= 7.0%) and well-controlled (HbA1c < 7.0%) patients with T2DM. RESULTS: PCSK9 levels were positively correlated with low-density lipoprotein cholesterol in both T2DM and non-T2DM. Univariable regression analysis revealed a positive association between PCSK9 and HbA1c in patients with T2DM (beta = 0.255, p = 0.001) but not in patients without diabetes (beta = 0.061, p = 0.128). Multiple-variable regression analysis exhibited that PCSK9 was independently correlated with HbA1c in T2DM after adjustment for traditional atherosclerotic risk factors (beta = 0.197, p = 0.020). Moreover, HbA1c level was higher in patients with the highest tertile of PCSK9 than that in the lowest tertile (p = 0.042). Additionally, higher levels of PCSK9 were found in poorly controlled group compared with the well-controlled group (p = 0.029). CONCLUSIONS: Data suggest a positive correlation of PCSK9 levels with HbA1c in patients with T2DM but not in patients without T2DM, indicating a potential role of PCSK9 in T2DM. Copyright (c) 2015 John Wiley & Sons, Ltd. CI - Copyright (c) 2015 John Wiley & Sons, Ltd. FAU - Yang, Sheng-Hua AU - Yang SH AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China. FAU - Li, Sha AU - Li S AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China. FAU - Zhang, Yan AU - Zhang Y AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China. FAU - Xu, Rui-Xia AU - Xu RX AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China. FAU - Guo, Yuan-Lin AU - Guo YL AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China. FAU - Zhu, Cheng-Gang AU - Zhu CG AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China. FAU - Wu, Na-Qiong AU - Wu NQ AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China. FAU - Cui, Chuan-Jue AU - Cui CJ AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China. FAU - Sun, Jing AU - Sun J AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China. FAU - Li, Jian-Jun AU - Li JJ AD - Division of Dyslipidemia, State Key Laboratory of Cardiovascular Disease, Fu Wai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College, BeiLiShi Road 167, Beijing, 100037, China. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20151028 PL - England TA - Diabetes Metab Res Rev JT - Diabetes/metabolism research and reviews JID - 100883450 RN - 0 (Biomarkers) RN - 0 (Glycated Hemoglobin A) RN - 0 (hemoglobin A1c protein, human) RN - EC 3.4.21.- (PCSK9 protein, human) RN - EC 3.4.21.- (Proprotein Convertase 9) RN - EC 3.4.21.- (Proprotein Convertases) RN - EC 3.4.21.- (Serine Endopeptidases) SB - IM MH - Biomarkers/*blood MH - Case-Control Studies MH - Coronary Angiography MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/blood/*diagnosis MH - Female MH - Follow-Up Studies MH - Glycated Hemoglobin/*analysis MH - Humans MH - Male MH - Middle Aged MH - Prognosis MH - Proprotein Convertase 9 MH - Proprotein Convertases/*blood MH - Risk Factors MH - Serine Endopeptidases/*blood OTO - NOTNLM OT - HbA1c OT - PCSK9 OT - diabetes mellitus OT - glycated haemoglobin OT - proprotein convertase subtilisin/kexin type 9 EDAT- 2015/09/18 06:00 MHDA- 2016/11/09 06:00 CRDT- 2015/09/18 06:00 PHST- 2015/05/28 00:00 [received] PHST- 2015/08/17 00:00 [accepted] PHST- 2015/09/18 06:00 [entrez] PHST- 2015/09/18 06:00 [pubmed] PHST- 2016/11/09 06:00 [medline] AID - 10.1002/dmrr.2712 [doi] PST - ppublish SO - Diabetes Metab Res Rev. 2016 Feb;32(2):193-9. doi: 10.1002/dmrr.2712. Epub 2015 Oct 28.