PMID- 26377676
OWN - NLM
STAT- MEDLINE
DCOM- 20160722
LR  - 20181113
IS  - 1432-1440 (Electronic)
IS  - 0946-2716 (Linking)
VI  - 93
IP  - 9
DP  - 2015 Sep
TI  - From GTP and G proteins to TRPC channels: a personal account.
PG  - 941-53
LID - 10.1007/s00109-015-1328-5 [doi]
AB  - By serendipity and good fortune, as a postdoctoral fellow in 1967, I landed at 
      the right place at the right time, as I was allowed to investigate the mechanism 
      by which hormones activate the enzyme adenylyl cyclase (then adenyl cyclase) in 
      Martin Rodbell's Laboratory at the NIH in Bethesda, Maryland. The work uncovered 
      first, the existence of receptors separate from the enzyme and then, the 
      existence of transduction mechanisms requiring guanosine-5'-triphosphate (GTP) 
      and Mg(2+). With my laboratory colleagues first and postdoctoral fellows after 
      leaving NIH, I participated in the development of the field "signal transduction 
      by G proteins," uncovered by molecular cloning several G-protein-coupled 
      receptors (GPCRs) and became interested in both the molecular makeup of 
      voltage-gated Ca channels and Ca2+ homeostasis downstream of activation of 
      phospholipase C (PLC) by the Gq/11 signaling pathway. We were able to confirm the 
      hypothesis that there would be mammalian homologues of the Drosophila "transient 
      receptor potential" channel and discovered the existence of six of the seven 
      mammalian genes, now called transient receptor potential canonical (TRPC) 
      channels. In the present article, I summarize from a bird's eye view of what I 
      feel were key findings along this path, not only from my laboratory but also from 
      many others, that allowed for the present knowledge of cell signaling involving G 
      proteins to evolve. Towards the end, I summarize roles of TRPC channels in health 
      and disease.
FAU - Birnbaumer, Lutz
AU  - Birnbaumer L
AD  - Neurobiology Laboratory, National Institute of Environmental Research, Research 
      Triangle Park, NC, 27009, USA. Birnbau1@gmail.com.
AD  - Institute of Biotechnology Research (IIB-INTECH), National University of San 
      Martin (UNSAM), Avenida 25 de Mayo y Francia, San Martin, CP1650, Provincia de 
      Buenos Aires, Argentina. Birnbau1@gmail.com.
LA  - eng
GR  - Z01-ES-101643/ES/NIEHS NIH HHS/United States
GR  - Z01-ES-101684/ES/NIEHS NIH HHS/United States
GR  - Intramural NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Intramural
PT  - Review
DEP - 20150916
PL  - Germany
TA  - J Mol Med (Berl)
JT  - Journal of molecular medicine (Berlin, Germany)
JID - 9504370
RN  - 0 (TRPC Cation Channels)
RN  - 86-01-1 (Guanosine Triphosphate)
RN  - EC 3.6.1.- (GTP-Binding Proteins)
SB  - IM
MH  - Animals
MH  - GTP-Binding Proteins/chemistry/genetics/*metabolism
MH  - Guanosine Triphosphate/genetics/*metabolism
MH  - Humans
MH  - Signal Transduction/genetics/physiology
MH  - TRPC Cation Channels/chemistry/genetics/*metabolism
OTO - NOTNLM
OT  - Ca signaling
OT  - G protein-coupled receptor
OT  - G proteins
OT  - GTPase
OT  - transient receptor potential channel
EDAT- 2015/09/18 06:00
MHDA- 2016/07/23 06:00
CRDT- 2015/09/18 06:00
PHST- 2015/04/20 00:00 [received]
PHST- 2015/07/28 00:00 [accepted]
PHST- 2015/09/18 06:00 [entrez]
PHST- 2015/09/18 06:00 [pubmed]
PHST- 2016/07/23 06:00 [medline]
AID - 10.1007/s00109-015-1328-5 [pii]
AID - 10.1007/s00109-015-1328-5 [doi]
PST - ppublish
SO  - J Mol Med (Berl). 2015 Sep;93(9):941-53. doi: 10.1007/s00109-015-1328-5. Epub 
      2015 Sep 16.