PMID- 26378383
OWN - NLM
STAT- MEDLINE
DCOM- 20160801
LR  - 20151013
IS  - 1742-2051 (Electronic)
IS  - 1742-2051 (Linking)
VI  - 11
IP  - 11
DP  - 2015 Nov
TI  - Effect of vitamin E succinate on the expression of the tumor necrosis 
      factor-related apoptosis-inducing ligand (TRAIL) receptor in gastric cancer cells 
      and CD4(+) T cells.
PG  - 3119-28
LID - 10.1039/c5mb00350d [doi]
AB  - Gastric malignancy, which shows poor prognosis, is one of the most frequent 
      causes of cancer-associated deaths. Vitamin E succinate (VES) inhibits cell 
      proliferation and induces apoptosis in a concentration- and time-dependent 
      manner. We explored the effect of VES on the expression of the tumor necrosis 
      factor-related apoptosis-inducing ligand (TRAIL) receptor in gastric cancer cells 
      and CD4(+) T cells. On one hand, VES dose-dependently regulated the expression of 
      the TRAIL receptor in gastric cancer cells. Moreover, the activation of the TRAIL 
      receptor, death receptor 4 (DR4), and death receptor 5 (DR5) in gastric cancer 
      cells increased for up to 12 h. On the other hand, the expression of TRAIL 
      protein in human CD4(+) T cells was obviously upregulated in the presence of VES. 
      On the basis of these findings, we combined VES and human CD4(+) T cells to 
      induce apoptosis of MKN28 human gastric cancer cells. The results showed that VES 
      induced higher gastric cancer cell apoptosis when combined with human CD4(+) T 
      cells than when applied alone. We conclude that VES can induce the expression of 
      TRAIL receptor in gastric cancer cells, as well as the expression of TRAIL in 
      CD4(+) T cells. Overall, our results provide a theoretical basis for future 
      immunotherapy studies.
FAU - Hou, Liying
AU  - Hou L
AD  - Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical 
      University, 150081 Harbin, China. wukun_15000@126.com.
FAU - Zhang, Haijin
AU  - Zhang H
FAU - Xu, Peixiang
AU  - Xu P
FAU - Zhang, Lijia
AU  - Zhang L
FAU - Zhang, Xuguang
AU  - Zhang X
FAU - Sun, Yanpei
AU  - Sun Y
FAU - Huang, Xiaoli
AU  - Huang X
FAU - Wu, Kun
AU  - Wu K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Mol Biosyst
JT  - Molecular bioSystems
JID - 101251620
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Receptors, TNF-Related Apoptosis-Inducing Ligand)
RN  - 0 (TNF-Related Apoptosis-Inducing Ligand)
RN  - H4N855PNZ1 (alpha-Tocopherol)
SB  - IM
MH  - Antineoplastic Agents/pharmacology
MH  - Apoptosis/drug effects
MH  - CD4-Positive T-Lymphocytes/drug effects/*metabolism
MH  - Cell Line, Tumor
MH  - Humans
MH  - Receptors, TNF-Related Apoptosis-Inducing Ligand/*metabolism
MH  - Stomach Neoplasms/*metabolism/pathology
MH  - TNF-Related Apoptosis-Inducing Ligand/metabolism
MH  - alpha-Tocopherol/*pharmacology
EDAT- 2015/09/18 06:00
MHDA- 2016/08/02 06:00
CRDT- 2015/09/18 06:00
PHST- 2015/09/18 06:00 [entrez]
PHST- 2015/09/18 06:00 [pubmed]
PHST- 2016/08/02 06:00 [medline]
AID - 10.1039/c5mb00350d [doi]
PST - ppublish
SO  - Mol Biosyst. 2015 Nov;11(11):3119-28. doi: 10.1039/c5mb00350d.