PMID- 26379544
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150918
LR  - 20201001
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 7
DP  - 2015
TI  - The impacts of a GO-game (Chinese chess) intervention on Alzheimer disease in a 
      Northeast Chinese population.
PG  - 163
LID - 10.3389/fnagi.2015.00163 [doi]
LID - 163
AB  - A GO game can enhance mental health, but its effects on Alzheimer Disease (AD) 
      remains unknown. To address the issue, 147 AD patients were randomly assigned 
      into control (without GO-game intervention), Short-time GO-Game Intervention 
      (SGGI, 1 h daily) and Long-time GO-game Intervention (LGGI, 2 h daily) groups. 
      After 6-month follow-up, the game reduced the mean score of Montgomery-Asberg 
      Depression Rating Scales (MADRS) of 4.72 (95% CI, 0.69 to 9.12) and Hospital 
      Anxiety and Depression Scale (HADS) of 1.75 (95% CI, 0.17-3.68), and increased 
      the mean score of Global Assessment of Functioning (GAF) of 4.95 (95% CI, 
      -1.37-9.18) and RAND-36 of 4.61 (95% CI, -2.75-11.32) (P < 0.05 via controls). A 
      GO-game intervention improved 9 of 11 items of KICA-dep (Kimberley Indigenous 
      Cognitive Assessment of Depression). Meanwhile, serum levels of brain derived 
      neurotrophic factor (BDNF) were higher in SGGI and LGGI groups (24.02 +/- 7.16 and 
      28.88 +/- 4.12 ng/ml respectively, P = 0.051) than those in controls (17.28 +/- 7.75 
      ng/ml) (P < 0.001). The serum levels of BDNF showed a negative relation with 
      MADRS and a positive relation with RAND-36 (P < 0.01). A GO-game intervention 
      ameliorates AD manifestations by up-regulating BDNF levels.
FAU - Lin, Qiao
AU  - Lin Q
AD  - Department of Internal Medicine, The Fourth Affiliated Hospital of China Medical 
      University Shenyang, China.
FAU - Cao, Yunpeng
AU  - Cao Y
AD  - Neural Department of Internal Medicine, The First Affiliated Hospital of China 
      Medical University Shenyang, China.
FAU - Gao, Jie
AU  - Gao J
AD  - Department of Anatomy, The First Affiliated Hospital of China Medical University 
      Shenyang, China.
LA  - eng
PT  - Journal Article
DEP - 20150825
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC4548213
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - GO game
OT  - Montgomery-Asberg Depression Rating Scale
OT  - RAND-36
OT  - brain-derived neurotrophic factor
EDAT- 2015/09/18 06:00
MHDA- 2015/09/18 06:01
PMCR- 2015/01/01
CRDT- 2015/09/18 06:00
PHST- 2015/05/15 00:00 [received]
PHST- 2015/08/10 00:00 [accepted]
PHST- 2015/09/18 06:00 [entrez]
PHST- 2015/09/18 06:00 [pubmed]
PHST- 2015/09/18 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2015.00163 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2015 Aug 25;7:163. doi: 10.3389/fnagi.2015.00163. 
      eCollection 2015.