PMID- 26379547
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150918
LR  - 20201001
IS  - 1663-4365 (Print)
IS  - 1663-4365 (Electronic)
IS  - 1663-4365 (Linking)
VI  - 7
DP  - 2015
TI  - Aberrant Brain Network Efficiency in Parkinson's Disease Patients with Tremor: A 
      Multi-Modality Study.
PG  - 169
LID - 10.3389/fnagi.2015.00169 [doi]
LID - 169
AB  - The coordination of spontaneous brain activity is widely enhanced relative to 
      compensation activity in Parkinson's disease (PD) with tremor; however, the 
      associated topological organization remains unclear. This study collected 
      magnetic resonance imaging data from 36 participants [i.e., 16 PD patients and 20 
      matched normal controls (NCs)] and constructed wavelet-based functional and 
      morphological brain networks for individual participants. Graph-based network 
      analysis indicated that the information translation efficiency in the functional 
      brain network was disrupted within the wavelet scale 2 (i.e., 0.063-0.125 Hz) in 
      PD patients. Compared with the NCs, the network local efficiency was decreased 
      and the network global efficiency was increased in PD patients. Network local 
      efficiency could effectively discriminate PD patients from the NCs using 
      multivariate pattern analysis, and could also describe the variability of tremor 
      based on a multiple linear regression model (MLRM). However, these observations 
      were not identified in the network global efficiency. Notably, the global and 
      local efficiency were both significantly increased in the morphological brain 
      network of PD patients. We further found that the global and local network 
      efficiency both worked well on PD classifications (i.e., using MVPA) and clinical 
      performance descriptions (i.e., using MLRM). More importantly, functional and 
      morphological brain networks were highly associated in terms of network local 
      efficiency in PD patients. This study sheds lights on network disorganization in 
      PD with tremor and helps for understanding the neural basis underlying this type 
      of PD.
FAU - Zhang, Delong
AU  - Zhang D
AD  - Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine , 
      Guangzhou , China ; Guangzhou University of Chinese Medicine Postdoctoral Mobile 
      Research Station , Guangzhou , China.
FAU - Wang, Jinhui
AU  - Wang J
AD  - Center for Cognition and Brain Disorders, Hangzhou Normal University , Hangzhou , 
      China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive 
      Impairments , Hangzhou , China.
FAU - Liu, Xian
AU  - Liu X
AD  - Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine , 
      Guangzhou , China.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine , 
      Guangzhou , China.
FAU - Liu, Bo
AU  - Liu B
AD  - Department of Radiology, Guangdong Provincial Hospital of Chinese Medicine , 
      Guangzhou , China.
LA  - eng
PT  - Journal Article
DEP - 20150831
PL  - Switzerland
TA  - Front Aging Neurosci
JT  - Frontiers in aging neuroscience
JID - 101525824
PMC - PMC4553412
OTO - NOTNLM
OT  - Parkinson's disease
OT  - individual morphological network
OT  - multivariate analysis
OT  - resting-state network
OT  - tremor
EDAT- 2015/09/18 06:00
MHDA- 2015/09/18 06:01
PMCR- 2015/01/01
CRDT- 2015/09/18 06:00
PHST- 2015/06/13 00:00 [received]
PHST- 2015/08/17 00:00 [accepted]
PHST- 2015/09/18 06:00 [entrez]
PHST- 2015/09/18 06:00 [pubmed]
PHST- 2015/09/18 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnagi.2015.00169 [doi]
PST - epublish
SO  - Front Aging Neurosci. 2015 Aug 31;7:169. doi: 10.3389/fnagi.2015.00169. 
      eCollection 2015.