PMID- 26379843
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20151026
LR  - 20201001
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 7
DP  - 2015
TI  - Gender disparity in the role of TLR2 in post-ischemic myocardial inflammation and 
      injury.
PG  - 10537-47
AB  - It is unclear whether Toll-like receptor (TLR) 2 plays a role in post-ischemic 
      myocardial inflammatory response and cardiac dysfunction in both males and 
      females. Permanent ischemia was induced in male and female C57BL/6J (wild-type, 
      WT) and TLR2 knockout (KO) mice. Infarct size and left ventricular (LV) function 
      were analyzed at day 7. Myocardial levels of monocyte chemoattractant protein-1 
      (MCP-1) and intercellular adhesion molecule-1 (ICAM-1), as well as neutrophil 
      infiltration, were assessed at day 3, and mononuclear cell accumulation was 
      determined at day 7. Lower MCP-1 and ICAM-1 levels, and reduced leukocyte 
      accumulation correlated with smaller infarct size and improved LV function in 
      male TLR2 KO mice. Female WT mice exhibited attenuated myocardial inflammatory 
      response and injury, and TLR2 KO in females did not provide a protective effect 
      although myocardial TLR2 levels in female WT mice were unaltered, and their 
      cardiac cells responded to bacterial TLR2 agonist properly. TLR2 KO in male mice 
      reduced post-ischemic myocardial inflammatory response, resulting in smaller 
      infarct sizes and improved cardiac function. However, TLR2 KO was not beneficial 
      in female mice. The gender disparity in the role of TLR2 in post-ischemic 
      myocardial inflammatory response and myocardial injury suggests that interception 
      with TLR2 signaling may have therapeutic potentials only in males.
FAU - Li, Jilin
AU  - Li J
AD  - Department of Surgery, University of Colorado Denver Aurora, Colorado 80045, USA 
      ; Division of Cardiology, The First Affiliated Hospital, Shantou University 
      Medical College Shantou 515041, China.
FAU - Ao, Lihua
AU  - Ao L
AD  - Department of Surgery, University of Colorado Denver Aurora, Colorado 80045, USA.
FAU - Zhai, Yufeng
AU  - Zhai Y
AD  - Department of Surgery, University of Colorado Denver Aurora, Colorado 80045, USA.
FAU - Cleveland, Joseph C Jr
AU  - Cleveland JC
AD  - Department of Surgery, University of Colorado Denver Aurora, Colorado 80045, USA.
FAU - Fullerton, David A
AU  - Fullerton DA
AD  - Department of Surgery, University of Colorado Denver Aurora, Colorado 80045, USA.
FAU - Meng, Xianzhong
AU  - Meng X
AD  - Department of Surgery, University of Colorado Denver Aurora, Colorado 80045, USA 
      ; Division of Cardiology, The First Affiliated Hospital, Shantou University 
      Medical College Shantou 515041, China.
LA  - eng
GR  - R01 AG039545/AG/NIA NIH HHS/United States
PT  - Journal Article
DEP - 20150715
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4565226
OTO - NOTNLM
OT  - Gender disparity
OT  - LV remodeling
OT  - TLR2
OT  - TLR4
OT  - heart failure
OT  - myocardial inflammatory response
EDAT- 2015/09/18 06:00
MHDA- 2015/09/18 06:01
PMCR- 2015/07/15
CRDT- 2015/09/18 06:00
PHST- 2015/04/12 00:00 [received]
PHST- 2015/06/20 00:00 [accepted]
PHST- 2015/09/18 06:00 [entrez]
PHST- 2015/09/18 06:00 [pubmed]
PHST- 2015/09/18 06:01 [medline]
PHST- 2015/07/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Jul 15;8(7):10537-47. eCollection 2015.