PMID- 26380729
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150918
LR  - 20201001
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 7
IP  - 7
DP  - 2015 Jul
TI  - Predictors of dynamic hyperinflation during the 6-minute walk test in stable 
      chronic obstructive pulmonary disease patients.
PG  - 1142-50
LID - 10.3978/j.issn.2072-1439.2015.07.08 [doi]
AB  - BACKGROUND: Dynamic hyperinflation (DH) is a major contributor to exercise 
      limitation in chronic obstructive pulmonary disease (COPD). Therefore, we aimed 
      to elucidate the physiological factors responsible for DH development during the 
      6-minute walk test (6MWT) in COPD patients and compare ventilatory response to 
      the 6MWT in hyperinflators and non-hyperinflators. METHODS: A total of 105 
      consecutive subjects with stable COPD underwent a 6MWT, and the Borg dyspnea 
      scale, oxygen saturation (SpO2), breathing pattern, and inspiratory capacity (IC) 
      were recorded before and immediately after walking. The change in IC was 
      measured, and subjects were divided into hyperinflators (DeltaIC >0.0 L) and 
      non-hyperinflators (DeltaIC </=0.0 L). Spirometry, the Modified Medical Research 
      Council (MMRC) dyspnea scale and St George's Respiratory Questionnaire (SGRQ) 
      were also assessed. RESULTS: DH was present in 66.67% of subjects. DeltaIC/IC was 
      significantly and negatively correlated with the small airway function. On 
      multiple stepwise regression analysis forced expiratory flow after exhaling 50% 
      of the forced vital capacity (FEF50%) was the only predictor of DeltaIC/IC. 
      Non-hyperinflators had a higher post-walking VT (t=2.419, P=0.017) and 
      post-walking VE (t=2.599, P=0.011) than the hyperinflators did. Age and resting 
      IC were independent predictors of the 6-minute walk distance (6MWD) in 
      hyperinflators. CONCLUSIONS: DH was considerably common in subjects with COPD. 
      Small airway function may partly contribute to the DH severity during walking. 
      The ventilator response to the 6MWT differed between hyperinflators and 
      non-hyperinflators. Resting hyperinflation is an important predictor of 
      functional exercise capacity in hyperinflators.
FAU - Chen, Rui
AU  - Chen R
AD  - 1 Department of Respiratory Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China ; 2 Laboratory of Rehabilitation, Guangdong 
      Provincial Hospital, Guangzhou 510055, China ; 3 Department of Respiratory 
      Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China 
      ; 4 Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China.
FAU - Lin, Lin
AU  - Lin L
AD  - 1 Department of Respiratory Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China ; 2 Laboratory of Rehabilitation, Guangdong 
      Provincial Hospital, Guangzhou 510055, China ; 3 Department of Respiratory 
      Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China 
      ; 4 Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China.
FAU - Tian, Jing-Wei
AU  - Tian JW
AD  - 1 Department of Respiratory Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China ; 2 Laboratory of Rehabilitation, Guangdong 
      Provincial Hospital, Guangzhou 510055, China ; 3 Department of Respiratory 
      Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China 
      ; 4 Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China.
FAU - Zeng, Bin
AU  - Zeng B
AD  - 1 Department of Respiratory Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China ; 2 Laboratory of Rehabilitation, Guangdong 
      Provincial Hospital, Guangzhou 510055, China ; 3 Department of Respiratory 
      Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China 
      ; 4 Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China.
FAU - Zhang, Lei
AU  - Zhang L
AD  - 1 Department of Respiratory Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China ; 2 Laboratory of Rehabilitation, Guangdong 
      Provincial Hospital, Guangzhou 510055, China ; 3 Department of Respiratory 
      Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China 
      ; 4 Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China.
FAU - Chen, Xin
AU  - Chen X
AD  - 1 Department of Respiratory Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China ; 2 Laboratory of Rehabilitation, Guangdong 
      Provincial Hospital, Guangzhou 510055, China ; 3 Department of Respiratory 
      Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China 
      ; 4 Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China.
FAU - Yan, Hai-Yan
AU  - Yan HY
AD  - 1 Department of Respiratory Diseases, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China ; 2 Laboratory of Rehabilitation, Guangdong 
      Provincial Hospital, Guangzhou 510055, China ; 3 Department of Respiratory 
      Diseases, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China 
      ; 4 Department of Clinical Laboratory, Sun Yat-sen Memorial Hospital, Sun Yat-sen 
      University, Guangzhou 510120, China.
LA  - eng
PT  - Journal Article
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC4522495
OTO - NOTNLM
OT  - Chronic obstructive pulmonary disease (COPD)
OT  - dynamic hyperinflation (DH)
OT  - exercise capacity
OT  - inspiratory capacity (IC)
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2015/09/19 06:00
MHDA- 2015/09/19 06:01
PMCR- 2015/07/01
CRDT- 2015/09/19 06:00
PHST- 2015/05/03 00:00 [received]
PHST- 2015/06/27 00:00 [accepted]
PHST- 2015/09/19 06:00 [entrez]
PHST- 2015/09/19 06:00 [pubmed]
PHST- 2015/09/19 06:01 [medline]
PHST- 2015/07/01 00:00 [pmc-release]
AID - jtd-07-07-1142 [pii]
AID - 10.3978/j.issn.2072-1439.2015.07.08 [doi]
PST - ppublish
SO  - J Thorac Dis. 2015 Jul;7(7):1142-50. doi: 10.3978/j.issn.2072-1439.2015.07.08.