PMID- 26380761
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150918
LR  - 20220331
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 7
IP  - 8
DP  - 2015 Aug
TI  - Insulin resistance, glucose intolerance and diabetes mellitus in obstructive 
      sleep apnoea.
PG  - 1343-57
LID - 10.3978/j.issn.2072-1439.2015.08.11 [doi]
AB  - Obstructive sleep apnoea (OSA) is a highly prevalent disorder, which conveys an 
      increased risk of cardiovascular disease and death. Type 2 diabetes mellitus 
      (T2DM), glucose intolerance and insulin resistance (IR) are common in subjects 
      with OSA, but a shared intimate relationship with obesity makes discerning an 
      independent link challenging. Nonetheless, mechanistic studies suggest that OSA 
      could contribute to impaired glucose metabolism via the effects of sleep 
      fragmentation, sympathetic excitation and intermittent hypoxia (IH) on pancreatic 
      B-cell function, insulin sensitivity, and systemic inflammation. In particular, 
      emerging data suggest that IH may have an important detrimental effect on adipose 
      tissue function and inflammation. Similarly, data from population-and 
      clinic-level studies suggest that OSA is independently related with the 
      prevalence and incidence of T2DM and IR, and may also lead to worse glycaemic 
      control in diabetics. However, the ability of continuous positive airway pressure 
      (CPAP) therapy to make a meaningful impact on T2DM or IR remains uncertain. In 
      this review we explore the available evidence linking OSA with IR, glucose 
      intolerance and T2DM, and discuss potential pathobiological mechanisms by which 
      sleep disordered breathing can affect metabolic health.
FAU - Kent, Brian D
AU  - Kent BD
AD  - 1 Pulmonary and Sleep Disorders Unit, Guy's and St Thomas' Hospital, London, UK ; 
      2 Pulmonary and Sleep Disorders Unit, St. Vincent's University Hospital, Dublin; 
      Ireland ; 3 School of Medicine and Medical Science, University College Dublin, 
      Dublin, Ireland.
FAU - McNicholas, Walter T
AU  - McNicholas WT
AD  - 1 Pulmonary and Sleep Disorders Unit, Guy's and St Thomas' Hospital, London, UK ; 
      2 Pulmonary and Sleep Disorders Unit, St. Vincent's University Hospital, Dublin; 
      Ireland ; 3 School of Medicine and Medical Science, University College Dublin, 
      Dublin, Ireland.
FAU - Ryan, Silke
AU  - Ryan S
AD  - 1 Pulmonary and Sleep Disorders Unit, Guy's and St Thomas' Hospital, London, UK ; 
      2 Pulmonary and Sleep Disorders Unit, St. Vincent's University Hospital, Dublin; 
      Ireland ; 3 School of Medicine and Medical Science, University College Dublin, 
      Dublin, Ireland.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
PMC - PMC4561252
OTO - NOTNLM
OT  - Obstructive sleep apnoea (OSA)
OT  - diabetes mellitus
OT  - inflammation
OT  - insulin resistance (IR)
OT  - intermittent hypoxia (IH)
COIS- Conflicts of Interest: The authors have no conflicts of interest to declare.
EDAT- 2015/09/19 06:00
MHDA- 2015/09/19 06:01
PMCR- 2015/08/01
CRDT- 2015/09/19 06:00
PHST- 2014/12/18 00:00 [received]
PHST- 2015/07/12 00:00 [accepted]
PHST- 2015/09/19 06:00 [entrez]
PHST- 2015/09/19 06:00 [pubmed]
PHST- 2015/09/19 06:01 [medline]
PHST- 2015/08/01 00:00 [pmc-release]
AID - jtd-07-08-1343 [pii]
AID - 10.3978/j.issn.2072-1439.2015.08.11 [doi]
PST - ppublish
SO  - J Thorac Dis. 2015 Aug;7(8):1343-57. doi: 10.3978/j.issn.2072-1439.2015.08.11.