PMID- 26380814
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150918
LR  - 20201001
IS  - 2214-5400 (Print)
IS  - 2214-5400 (Electronic)
IS  - 2214-5400 (Linking)
VI  - 6
DP  - 2015 Dec
TI  - Association of the NAD(P)H oxidase p22 phox gene C242T polymorphism with type 2 
      diabetes mellitus, diabetic nephropathy, and carotid atherosclerosis with type 2 
      diabetes mellitus: A meta-analysis.
PG  - 1-8
LID - 10.1016/j.mgene.2015.07.009 [doi]
AB  - BACKGROUND: Several epidemiological studies have evaluated the association 
      between the NAD(P)H oxidase p22 phox gene C242T polymorphism and the risk of type 
      2 diabetes mellitus (T2DM), diabetic nephropathy (DN), and carotid 
      atherosclerosis with T2DM (CA), but the results are inconclusive. This 
      meta-analysis was therefore designed to clarify these controversies. METHODS: 
      Systematic searches were performed using electronic databases such as MEDLINE, 
      PubMed, EMBASE, and China National Knowledge Infrastructure, as well as through 
      manual searching of the references of identified articles. A total of 11 
      publications were eligible for this meta-analysis after running a search on the 
      NAD(P)H oxidase p22 phox gene C242T polymorphism, including 7 with outcomes for 
      T2DM, 7 with outcomes for DN, and 3 with outcomes for CA. The pooled odds ratio 
      (OR) with a 95% confidence interval (CI) was calculated using a fixed effects 
      model (FEM) or a random effects model (REM). Publication bias was tested by 
      Begg's funnel plot analysis. Sensitivity analysis was also performed. RESULTS: 
      The results showed a significant association between the NAD(P)H oxidase p22 phox 
      gene C242T polymorphism and T2DM risk in the allelic model (REM: OR = 1.23, 95% 
      CI = 1.06-1.43), additive model (FEM: OR = 1.61, 95% CI = 1.14-2.26), and 
      recessive model (FEM: OR = 1.50, 95% CI = 1.10-2.05). A significant association 
      was also observed for DN in the allelic model (REM: OR = 1.25, 95% 
      CI = 1.06-1.47), additive model (FEM: OR = 1.61, 95% CI = 1.08-2.38), and 
      dominant model (REM: OR = 1.26, 95% CI = 1.03-1.54). However, no association was 
      observed for CA. Similar results were obtained in subgroup analysis based on 
      ethnicity. CONCLUSIONS: Results of this meta-analysis suggest that the NAD(P)H 
      oxidase p22 phox gene 242T allele might be associated with an increased risk of 
      T2DM and DN, but not CA.
FAU - Li, Tao
AU  - Li T
AD  - Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang 
      050017, China.
FAU - Xi, Hai-Feng
AU  - Xi HF
AD  - Hebei Provincial Health and Family Planning Commission, Shijiazhuang, China.
FAU - Luo, Hong-Min
AU  - Luo HM
AD  - Department of Nephrology Third Hospital, Hebei Medical University, Shijiazhuang, 
      China.
FAU - Liu, Wen-Xuan
AU  - Liu WX
AD  - Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang 
      050017, China.
FAU - Gao, Xia
AU  - Gao X
AD  - Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang 
      050017, China.
FAU - Liu, Dian-Wu
AU  - Liu DW
AD  - Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang 
      050017, China.
FAU - Yang, Lei
AU  - Yang L
AD  - Department of Epidemiology and Statistic, Hebei Medical University, Shijiazhuang 
      050017, China.
LA  - eng
PT  - Journal Article
DEP - 20150825
PL  - Netherlands
TA  - Meta Gene
JT  - Meta gene
JID - 101627670
PMC - PMC4556815
OTO - NOTNLM
OT  - Carotid atherosclerosis
OT  - Diabetic nephropathy
OT  - Polymorphism
OT  - Type 2 diabetes mellitus
OT  - p22 phox
EDAT- 2015/09/19 06:00
MHDA- 2015/09/19 06:01
PMCR- 2015/08/25
CRDT- 2015/09/19 06:00
PHST- 2015/04/18 00:00 [received]
PHST- 2015/07/23 00:00 [revised]
PHST- 2015/07/29 00:00 [accepted]
PHST- 2015/09/19 06:00 [entrez]
PHST- 2015/09/19 06:00 [pubmed]
PHST- 2015/09/19 06:01 [medline]
PHST- 2015/08/25 00:00 [pmc-release]
AID - S2214-5400(15)00043-2 [pii]
AID - 10.1016/j.mgene.2015.07.009 [doi]
PST - epublish
SO  - Meta Gene. 2015 Aug 25;6:1-8. doi: 10.1016/j.mgene.2015.07.009. eCollection 2015 
      Dec.